-
作者：Mota, Maria M.
-
作者：Igarashi, Ryo; Oda, Mayumi; Okada, Ryo; Yano, Tomoki; Takahashi, Sirirat; Pastuhov, Strahil; Matano, Mami; Masuda, Norio; Togasaki, Kazuhiro; Ohta, Yuki; Sato, Saeko; Hishiki, Takako; Suematsu, Makoto; Itoh, Manabu; Fujii, Masayuki; Sato, Toshiro
作者单位：Keio University; Keio University; JSR Corporation; Keio University
摘要：Proliferating hepatocytes often undergo ductal metaplasia to balance the energy trade-off between cellular functions and replication, hindering the expansion of human adult hepatocytes with functional competency1. Here we demonstrate that the combined activation of Wnt and STAT3 signalling enables long-term self-renewal of human adult hepatocyte organoids. YAP activation facilitates hepatocyte proliferation but commits it towards the biliary duct lineage. By contrast, STAT3 activation by oncos...
-
作者：Nern, Aljoscha; Loesche, Frank; Takemura, Shin-ya; Burnett, Laura E.; Dreher, Marisa; Gruntman, Eyal; Hoeller, Judith; Huang, Gary B.; Januszewski, Michal; Klapoetke, Nathan C.; Koskela, Sanna; Longden, Kit D.; Lu, Zhiyuan; Preibisch, Stephan; Qiu, Wei; Rogers, Edward M.; Seenivasan, Pavithraa; Zhao, Arthur; Bogovic, John; Canino, Brandon S.; Clements, Jody; Cook, Michael; Finley-May, Samantha; Flynn, Miriam A.; Hameed, Imran; Fragniere, Alexandra M. C.; Hayworth, Kenneth J.; Hopkins, Gary Patrick; Hubbard, Philip M.; Katz, William T.; Kovalyak, Julie; Lauchie, Shirley A.; Leonard, Meghan; Lohff, Alanna; Maldonado, Charli A.; Mooney, Caroline; Okeoma, Nneoma; Olbris, Donald J.; Ordish, Christopher; Paterson, Tyler; Phillips, Emily M.; Pietzsch, Tobias; Salinas, Jennifer Rivas; Rivlin, Patricia K.; Schlegel, Philipp; Scott, Ashley L.; Scuderi, Louis A.; Takemura, Satoko; Talebi, Iris; Thomson, Alexander; Trautman, Eric T.; Umayam, Lowell; Walsh, Claire; Walsh, John J.; Xu, C. Shan; Yakal, Emily A.; Yang, Tansy; Zhao, Ting; Funke, Jan; George, Reed; Hess, Harald F.; Jefferis, Gregory S. X. E.; Knecht, Christopher; Korff, Wyatt; Plaza, Stephen M.; Romani, Sandro; Saalfeld, Stephan; Scheffer, Louis K.; Berg, Stuart; Rubin, Gerald M.; Reiser, Michael B.
作者单位：Howard Hughes Medical Institute; University of Toronto; University Toronto Scarborough; Alphabet Inc.; Google Incorporated; MRC Laboratory Molecular Biology; University of Cambridge
摘要：Vision provides animals with detailed information about their surroundings and conveys diverse features such as colour, form and movement across the visual scene. Computing these parallel spatial features requires a large and diverse network of neurons. Consequently, from flies to humans, visual regions in the brain constitute half its volume. These visual regions often have marked structure-function relationships, with neurons organized along spatial maps and with shapes that directly relate ...
-
作者：Machery, Edouard; Doris, John M.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Cornell University
-
作者：Sumida, Stuart S.
作者单位：California State University System; California State University San Bernardino
-
作者：Xie, Zhiyuan; Sokolov, Ilya; Osmala, Maria; Yue, Xue; Bower, Grace; Pett, J. Patrick; Chen, Yinan; Wang, Kai; Cavga, Ayse Derya; Popov, Alexander; Teichmann, Sarah A.; Morgunova, Ekaterina; Kvon, Evgeny Z.; Yin, Yimeng; Taipale, Jussi
作者单位：Tongji University; University of Cambridge; Wellcome Trust Sanger Institute; University of Helsinki; University of California System; University of California Irvine; Wellcome Trust Sanger Institute; European Synchrotron Radiation Facility (ESRF); University of Cambridge; Karolinska Institutet; Tongji University
摘要：In the same way that the mRNA-binding specificities of transfer RNAs define the genetic code, the DNA-binding specificities of transcription factors (TFs) form the molecular basis of the gene regulatory code1,2. The human gene regulatory code is much more complex than the genetic code, in particular because there are more than 1,600 TFs that commonly interact with each other. TF-TF interactions are required for specifying cell fate and executing cell-type-specific transcriptional programs. Des...
-
作者：O'Connor, Jingmai; Clark, Alexander; Kuo, Pei-Chen; Kiat, Yosef; Fabbri, Matteo; Shinya, Akiko; Van Beek, Constance; Lu, Jing; Wang, Min; Hu, Han
作者单位：Field Museum of Natural History (Chicago); University of Chicago; Tel Aviv University; Tel Aviv University; Johns Hopkins University; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS
摘要：Here we report on the nearly complete and uncrushed 14th specimen of Archaeopteryx. Exceptional preservation and preparation guided by micro-computed tomographic data make this one of the best exemplars of this iconic taxon, preserving important data regarding skeletal transformation and plumage evolution in relation to the acquisition of flight during early avian evolution. The ventrolaterally exposed skull reveals a palatal morphology intermediate between troodontids1 and crownward Cretaceou...
-
作者：Tintelnot, Joseph; Xu, Yang; Lesker, Till R.; Schoenlein, Martin; Konczalla, Leonie; Giannou, Anastasios D.; Pelczar, Penelope; Kylies, Dominik; Puelles, Victor G.; Bielecka, Agata A.; Peschka, Manuela; Cortesi, Filippo; Riecken, Kristoffer; Jung, Maximilian; Amend, Lena; Broering, Tobias S.; Trajkovic-Arsic, Marija; Siveke, Jens T.; Renne, Thomas; Zhang, Danmei; Boeck, Stefan; Strowig, Till; Uzunoglu, Faik G.; Guengoer, Cenap; Stein, Alexander; Izbicki, Jakob R.; Bokemeyer, Carsten; Sinn, Marianne; Kimmelman, Alec C.; Huber, Samuel; Gagliani, Nicola
-
作者：Shimoni, Neta Gazit; Tose, Amanda J.; Seng, Charlotte; Jin, Yihan; Lukacsovich, Tamas; Yang, Hongbin; Verharen, Jeroen P. H.; Liu, Christine; Tanios, Michael; Hu, Eric; Read, Jonathan; Tang, Lilly W.; Lim, Byung Kook; Tian, Lin; Foeldy, Csaba; Lammel, Stephan
作者单位：University of California System; University of California Berkeley; University of Zurich; University of California System; University of California Davis; Zhejiang University; Zhejiang University; University of California System; University of California San Diego; Max Planck Society
摘要：Calorie-rich foods, particularly those that are high in fat and sugar, evoke pleasure in both humans and animals1. However, prolonged consumption of such foods may reduce their hedonic value, potentially contributing to obesity2, 3-4. Here we investigated this phenomenon in mice on a chronic high-fat diet (HFD). Although these mice preferred high-fat food over regular chow in their home cages, they showed reduced interest in calorie-rich foods in a no-effort setting. This paradoxical decrease ...
-
作者：Mahon, Francois-Xavier
作者单位：UNICANCER; Institut Bergonie
