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作者：Liu, Fachen; Mao, Ruilin; Liu, Zhiqiang; Du, Jinlong; Gao, Peng
作者单位：Peking University; Peking University; Peking University; Chinese Academy of Sciences; Peking University; Peking University; Tsinghua University; Collaborative Innovation Center of Quantum Matter
摘要：Understanding thermal transport mechanisms across material interfaces is crucial for advancing semiconductor technologies, particularly in miniaturized devices operating under extreme power densities1,2. Although the interface phonon-mediated processes are theoretically established3, 4, 5-6 as the dominant mechanism for interfacial thermal transport in semiconductors7, their nanoscale dynamics remain experimentally elusive owing to challenges in measuring the temperature and non-equilibrium ph...
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作者：Zhang, Jiawei; Feng, Xiaoyuan; Li, Meng; Liu, Yang; Liu, Min; Hou, Li-Jun; Dong, Hong-Po
作者单位：East China Normal University; Shenzhen University; East China Normal University
摘要：Research on the morphology, physiology and genomics of Asgard archaea has provided valuable insights into the evolutionary history of eukaryotes1, 2-3. A previous study suggested that eukaryotes are nested within Heimdallarchaeia4, but their exact phylogenetic placement within Asgard archaea remains controversial4,5. This debate complicates understanding of the metabolic features and timescales of early eukaryotic ancestors. Here we generated 223 metagenome-assembled nearly complete genomes of...
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作者：Feng, Cong; Chen, Baizhi; Hofer, Julie; Shi, Yan; Jiang, Mei; Song, Bo; Cheng, Hong; Lu, Lu; Wang, Luyao; Howard, Alex; Bendahmane, Abdel; Fouchal, Anissa; Moreau, Carol; Sawada, Chie; LeSignor, Christine; Zhang, Cuijun; Vikeli, Eleni; Tsanakas, Georgios; Zhao, Hang; Cheema, Jitender; Barclay, J. Elaine; Hou, Junliang; Sayers, Liz; Wingen, Luzie; Vigouroux, Marielle; Vickers, Martin; Ambrose, Mike; Dalmais, Marion; Higuera-Poveda, Paola; Li, Pengfeng; Yuan, Quan; Spanner, Rebecca; Horler, Richard; Wouters, Roland; Chundakkad, Smitha; Wu, Tian; Zhao, Xiaoxiao; Li, Xiuli; Sun, Yuchen; Huang, Zejian; Wu, Zhen; Deng, Xing Wang; Steuernagel, Burkhard; Domoney, Claire; Ellis, Noel; Chayut, Noam; Cheng, Shifeng
作者单位：Guangdong Laboratory for Lingnan Modern Agriculture; Chinese Academy of Agricultural Sciences; Agriculture Genomes Institute at Shenzhen, CAAS; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; INRAE; Universite Paris Saclay; Universite Paris Cite; INRAE; Universite Bourgogne Europe; INRAE; Institut Agro; AgroSup Dijon; European Molecular Biology Laboratory (EMBL); European Bioinformatics Institute; University of Minnesota System; University of Minnesota Twin Cities; Peking University; Peking University
摘要：Mendel1 studied in detail seven pairs of contrasting traits in pea (Pisum sativum), establishing the foundational principles of genetic inheritance. Here we investigate the genetic architecture that underlies these traits and uncover previously undescribed alleles for the four characterized Mendelian genes2, 3, 4, 5, 6-7, including a rare revertant of Mendel's white-flowered a allele. Primarily, we focus on the three remaining uncharacterized traits and find that (1) an approximately 100-kb ge...
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作者：Eickhoff, Patrik; Sonmez, Ceylan; Fisher, Charlotte E. L.; Inian, Oviya; Roumeliotis, Theodoros I.; dello Stritto, Angela; Mansfeld, Jorg; Choudhary, Jyoti S.; Guettler, Sebastian; Lottersberger, Francisca; Douglas, Max E.
作者单位：Royal Marsden NHS Foundation Trust; University of London; Institute of Cancer Research - UK; Linkoping University; University of London; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust; Royal Marsden NHS Foundation Trust; University of London; Institute of Cancer Research - UK; University of London; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust
摘要：During classical non-homologous end joining (cNHEJ), DNA-dependent protein kinase (DNA-PK) encapsulates free DNA ends, forming a recruitment platform for downstream end-joining factors including ligase 4 (LIG4)1. DNA-PK can also bind telomeres and regulate their resection2, 3-4, but does not initiate cNHEJ at this position. How the end-joining process is regulated in this context-specific manner is currently unclear. Here we show that the shelterin components TRF2 and RAP1 form a complex with ...
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作者：[Anonymous]
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作者：Fell, Christopher W.; Villiger, Lukas; Lim, Justin; Hiraizumi, Masahiro; Tagliaferri, Dario; Yarnall, Matthew T. N.; Lee, Anderson; Jiang, Kaiyi; Kayabolen, Alisan; Krajeski, Rohan N.; Schmitt-Ulms, Cian; Ramani, Harsh; Yousef, Sarah M.; Roberts, Nathaniel; Vakulskas, Christopher A.; Nishimasu, Hiroshi; Abudayyeh, Omar O.; Gootenberg, Jonathan S.
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Adventist Health Services; AdventHealth; Mass General Brigham; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Massachusetts Institute of Technology (MIT); University of Tokyo; Integrated DNA Technologies IDT; University of Tokyo
摘要：Retroelements have a critical role in shaping eukaryotic genomes. For instance, site-specific non-long terminal repeat retrotransposons have spread widely through preferential integration into repetitive genomic sequences, such as microsatellite regions and ribosomal DNA genes1, 2, 3, 4, 5-6. Despite the widespread occurrence of these systems, their targeting constraints remain unclear. Here we use a computational pipeline to discover multiple new site-specific retrotransposon families, profil...
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作者：Basilio, Humberto
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作者：Su, Cong; Cui, Haotian; Wang, Weiwei; Liu, Yong; Cheng, Zhenyu; Wang, Chen; Yang, Mengqiao; Qu, Liwen; Li, Ye; Cai, Yuejin; He, Siyang; Zheng, Jiaxin; Zhao, Pingping; Xu, Ping; Dai, Junbiao; Tang, Hongzhi
作者单位：Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Chinese Academy of Agricultural Sciences; Guangdong Laboratory for Lingnan Modern Agriculture
摘要：Industrial wastewater, petroleum pollution and plastic contamination are significant threats to global marine biosecurity because of their toxic, mutagenic and persistent nature1. The use of microorganisms in bioremediation has been constrained by the complexity of organic pollutants and limited tolerance to saline stress2. In this study, we used synthetic biology to engineer Vibrio natriegens into a strain capable of bioremediating complex organic pollutants in saline wastewater and soils. Th...
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作者：Ghitani, Nima; von Buchholtz, Lars J.; MacDonald, Donald Iain; Falgairolle, Melanie; Nguyen, Minh Q.; Licholai, Julia A.; Ryba, Nicholas J. P.; Chesler, Alexander T.
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR); National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
摘要：Somatosensory neurons encode detailed information about touch and temperature and are the peripheral drivers of pain1,2. Here by combining functional imaging with multiplexed in situ hybridization3, we determined how heat and mechanical stimuli are encoded across neuronal classes and how inflammation transforms this representation to induce heat hypersensitivity, mechanical allodynia and continuing pain. Our data revealed that trigeminal neurons innervating the cheek exhibited complete segrega...
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作者：Kataoka, Masaya
