作者：Chen, Xingyu; Shen, Yiling; Choi, Suhyeon; Abdel-Hafiz, Hany A.; Basu, Mukta; Hoelzen, Lena; Tufano, Martina; Kailasam Mani, Saravana Kumar; Ranjpour, Maryam; Zhu, Jiani; Ramanujan, V. Krishnan; Koltsova, Ekaterina K.; Calsavara, Vinicius F.; Knott, Simon R. V.; Theodorescu, Dan
作者单位：Cedars Sinai Medical Center; Cedars Sinai Medical Center; Tsinghua University; Cedars Sinai Medical Center; Cedars Sinai Medical Center; Cedars Sinai Medical Center; Cedars Sinai Medical Center; Johns Hopkins University; University of Arizona
摘要：Loss of the Y chromosome (LOY) in peripheral blood mononuclear cells (PBMCs) is the most common somatic alteration in men and is associated with higher mortality from epithelial cancers1, 2-3. In tumours, epithelial LOY is also associated with poor survival4, 5, 6-7. This raises several fundamental questions, such as why LOY in PBMCs drives cancer mortality and whether there is a relationship between LOY in PBMCs, PBMC-derived immune cells and cancer cells (and, if so, what its consequences ar...
作者：Milojevic, Stasa
作者单位：Indiana University System; Indiana University Bloomington
作者：Brown, Peter
作者单位：Inria; IMT - Institut Mines-Telecom; Institut Polytechnique de Paris; Telecom Paris
