8077期

最新文章

• Emerging evidence of abrupt changes in the Antarctic environment AI翻译
  作者：Abram, Nerilie J.; Purich, Ariaan; England, Matthew H.; Mccormack, Felicity S.; Strugnell, Jan M.; Bergstrom, Dana M.; Vance, Tessa R.; Stal, Tobias; Wienecke, Barbara; Heil, Petra; Doddridge, Edward W.; Sallee, Jean-Baptiste; Williams, Thomas J.; Reading, Anya M.; Mackintosh, Andrew; Reese, Ronja; Winkelmann, Ricarda; Klose, Ann Kristin; Boyd, Philip W.; Chown, Steven L.; Robinson, Sharon A.
  作者单位：Australian National University; Australian National University; Australian National University; Monash University; Monash University; University of New South Wales Sydney; University of New South Wales Sydney; James Cook University; James Cook University; James Cook University; University of Wollongong; University of Johannesburg; University of Tasmania; University of Tasmania; Australian Antarctic Division; University of Tasmania; University of Tasmania; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Museum National d'Histoire Naturelle (MNHN); Sorbonne Universite; Northumbria University; Max Planck Society; Potsdam Institut fur Klimafolgenforschung; University of Potsdam; University of Wollongong
  摘要：Human-caused climate change worsens with every increment of additional warming, although some impacts can develop abruptly. The potential for abrupt changes is far less understood in the Antarctic compared with the Arctic, but evidence is emerging for rapid, interacting and sometimes self-perpetuating changes in the Antarctic environment. A regime shift has reduced Antarctic sea-ice extent far below its natural variability of past centuries, and in some respects is more abrupt, non-linear and ...
• Selective remodelling of the adipose niche in obesity and weight loss AI翻译
  作者：Miranda, Antonio M. A.; McAllan, Liam; Mazzei, Guianfranco; Andrew, Ivan; Davies, Iona; Ertugrul, Meryem; Kenkre, Julia; Kudo, Hiromi; Carrelha, Joana; Patel, Bhavik; Newton, Sophie; Zhang, Weihua; Pollard, Alice; Cross, Amy; McCallion, Oliver; Jang, Mikyung; Choi, Ka Lok; Brown, Scarlett; Rasool, Yasmin; Adamo, Marco; Elkalaawy, Mohamed; Jenkinson, Andrew; Mohammadi, Borzoueh; Hashemi, Majid; Goldin, Robert; Game, Laurence; Hester, Joanna; Issa, Fadi; Ryan, Dylan G.; Ortega, Patricia; Ahmed, Ahmed R.; Batterham, Rachel L.; Chambers, John C.; Kooner, Jaspal S.; Baranasic, Damir; Noseda, Michela; Tan, Tricia; Scott, William R.
  作者单位：Imperial College London; Imperial College London; Imperial College London; Imperial College London; Imperial College London; University of Oxford; Imperial College London; University of Oxford; University of London; University College London; University College London Hospitals NHS Foundation Trust; University of Cambridge; Imperial College London; University of London; University College London; King's College London; University College London Hospitals NHS Foundation Trust; Imperial College London; Nanyang Technological University; Imperial College London; Rudjer Boskovic Institute
  摘要：Weight loss significantly improves metabolic and cardiovascular health in people with obesity1, 2-3. The remodelling of adipose tissue (AT) is central to these varied and important clinical effects4. However, surprisingly little is known about the underlying mechanisms, presenting a barrier to treatment advances. Here we report a spatially resolved single-nucleus atlas (comprising 171,247 cells from 70 people) investigating the cell types, molecular events and regulatory factors that reshape h...
• Early life high fructose impairs microglial phagocytosis and neurodevelopment AI翻译
  作者：Wang, Zhaoquan; Lipshutz, Allie; Martinez de la Torre, Celia; Trzeciak, Alissa J.; Liu, Zong-Lin; Miranda, Isabella C.; Lazarov, Tomi; Codo, Ana C.; Romero-Pichardo, Jesus E.; Nair, Achuth; Schild, Tanya; Saitz Rojas, Waleska; Saavedra, Pedro H. V.; Baako, Ann K.; Fadojutimi, Kelvin; Downey, Michael S.; Geissmann, Frederic; Faraco, Giuseppe; Gan, Li; Etchegaray, Jon Iker; Lucas, Christopher D.; Tanasova, Marina; Parkhurst, Christopher N.; Zeng, Melody Y.; Keshari, Kayvan R.; Perry, Justin S. A.
  作者单位：Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; Memorial Sloan Kettering Cancer Center; Northeastern University; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Washington University (WUSTL); Oklahoma Medical Research Foundation; University of Edinburgh; Michigan Technological University; Michigan Technological University; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine
  摘要：Despite the success of fructose as a low-cost food additive, epidemiological evidence suggests that high fructose consumption during pregnancy or adolescence is associated with disrupted neurodevelopment1, 2-3. An essential step in appropriate mammalian neurodevelopment is the phagocytic elimination of newly formed neurons by microglia, the resident professional phagocyte of the central nervous system4. Whether high fructose consumption in early life affects microglial phagocytosis and whether...
• Low-energy nuclear fusion boosted by electrochemistry AI翻译
  作者：McKeown-Green, Amy; Dionne, Jennifer A.
  作者单位：Stanford University; Stanford University
• Ancient coins unveil web of trade across southeast Asia AI翻译
  作者：[Anonymous]
• Subnucleosome preference of human chromatin remodeller SMARCAD1 AI翻译
  作者：Hu, Pengjing; Sun, Jingxi; Sun, Hongyao; Chen, Kangjing; Sia, Youyang; Xia, Xian; Xi, Qiaoran; Chen, Zhucheng
  作者单位：Tsinghua University; University of California System; University of California Los Angeles
  摘要：Chromatin remodellers are pivotal in the regulation of nucleosome dynamics in cells, and they are important for chromatin packaging, transcription, replication and DNA repair1. Here we show that the human chromatin remodeller SMARCAD1 exhibits a substrate preference for subnucleosomal particles over the canonical nucleosome. Cryo-electron microscopy structures of SMARCAD1 bound to the nucleosome and hexasome provide mechanistic insights into the substrate selectivity. SMARCAD1 binds to the hex...
• Why amphibious, wet environments hold the key to climate adaptation AI翻译
  作者：Ananya
• Astronomers gave up this comet for dead - but they were wrong AI翻译
  作者：[Anonymous]
• Kupffer cell programming by maternal obesity triggers fatty liver disease AI翻译
  作者：Huang, Hao; Balzer, Nora R.; Seep, Lea; Splichalova, Iva; Blank-Stein, Nelli; Viola, Maria Francesca; Franco Taveras, Eliana; Acil, Kerim; Fink, Diana; Petrovic, Franzisca; Makdissi, Nikola; Bayar, Seyhmus; Mauel, Katharina; Radwaniak, Carolin; Zurkovic, Jelena; Kayvanjoo, Amir H.; Wunderling, Klaus; Jessen, Malin; Yaghmour, Mohamed H.; Kenner, Lukas; Ulas, Thomas; Grein, Stephan; Schultze, Joachim L.; Scott, Charlotte L.; Guilliams, Martin; Liu, Zhaoyuan; Ginhoux, Florent; Beyer, Marc D.; Thiele, Christoph; Meissner, Felix; Hasenauer, Jan; Wachten, Dagmar; Mass, Elvira
  作者单位：University of Bonn; University of Bonn; University of Bonn; University of Bonn; University of Bonn; Medical University of Vienna; Medical University of Vienna; University of Veterinary Medicine Vienna; Umea University; Medical University of Vienna; Helmholtz Association; German Center for Neurodegenerative Diseases (DZNE); University of Bonn; Helmholtz Association; German Center for Neurodegenerative Diseases (DZNE); University of Bonn; Ghent University; Ghent University; Flanders Institute for Biotechnology (VIB); Ghent University; Flanders Institute for Biotechnology (VIB); Chinese Academy of Sciences; Shanghai Jiao Tong University; Universite Paris Saclay; Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Gustave Roussy; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); Helmholtz Association; German Center for Neurodegenerative Diseases (DZNE); University of Bonn
  摘要：Kupffer cells (KCs) are tissue-resident macrophages that colonize the liver early during embryogenesis1. Upon liver colonization, KCs rapidly acquire a tissue-specific transcriptional signature, mature alongside the developing liver and adapt to its functions1, 2-3. Throughout development and adulthood, KCs perform distinct core functions that are essential for liver and organismal homeostasis, including supporting fetal erythropoiesis, postnatal erythrocyte recycling and liver metabolism4. Ho...
• Flat-panel laser displays through large-scale photonic integrated circuits AI翻译
  作者：Shi, Zhujun; Cheng, Risheng; Wei, Guohua; Hickman, Steven A.; Shin, Min Chul; Topalian, Peter; Wang, Lei; Coso, Dusan; Wang, Youmin; Wang, Qingjun; Le, Brian; Lee, Lizzy; Lopez, Daniel; Wu, Yuhang; Braxton, Sean; Koshelev, Alexander; Parsons, Maxwell F.; Agarwal, Rahul; Silverstein, Barry; Wang, Yun; Calafiore, Giuseppe
  摘要：Laser-based displays are highly sought after for their superior brightness and colour performance1, especially in advanced applications such as augmented reality (AR)2. However, their broader use has been hindered by bulky projector designs and complex optical module assemblies3. Here we introduce a laser display architecture enabled by large-scale visible photonic integrated circuits (PICs)4, 5, 6-7 to address these challenges. Unlike previous projector-style laser displays, this architecture...