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作者：Ananya
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作者：Chen, Kuo-Yi; Maiwald, Jannis; Schauer, Phil A.; Issinski, Sergey; Garcia, Fatima H.; Oldford, Ryan; Egoriti, Luca; Higashino, Shota; Vakili, Aref E.; Wen, Yunzhou; Koh, Joseph Z. X.; Schenkel, Thomas; Stolar, Monika; Brown, Amanda K.; Berlinguette, Curtis P.
作者单位：University of British Columbia; University of British Columbia; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of British Columbia; University of British Columbia; Canadian Institute for Advanced Research (CIFAR)
摘要：Nuclear fusion research for energy applications aims to create conditions that release more energy than required to initiate the fusion process1. To generate meaningful amounts of energy, fuels such as deuterium need to be spatially confined to increase the collision probability of particles2, 3-4. We therefore set out to investigate whether electrochemically loading a metal lattice with deuterium fuel could increase the probability of nuclear fusion events. Here we report a benchtop fusion re...
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作者：Rosen, Evan D.; Emont, Margo P.
作者单位：Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; University of Chicago
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作者：[Anonymous]
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作者：Liu, Caixuan; Wu, Kejia; Choi, Hojun; Han, Hannah L.; Zhang, Xueli; Watson, Joseph L.; Ahn, Green; Zhang, Jason Z.; Shijo, Sara; Good, Lydia L.; Fischer, Charlotte M.; Bera, Asim K.; Kang, Alex; Brackenbrough, Evans; Coventry, Brian; Hick, Derrick R.; Qamar, Seema; Li, Xinting; Decarreau, Justin; Gerben, Stacey R.; Yang, Wei; Goreshnik, Inna; Vafeados, Dionne; Wang, Xinru; Lamb, Mila; Murray, Analisa; Kenny, Sebastian; Bauer, Magnus S.; Hoofnagle, Andrew N.; Zhu, Ping; Knowles, Tuomas P. J.; Baker, David
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Washington; University of Washington Seattle; University of Cambridge; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); University of Cambridge; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle
摘要：Proteins that bind to intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) with high affinity and specificity could be useful for therapeutic and diagnostic applications1, 2, 3-4. However, a general methodology for targeting IDPs or IDRs has yet to be developed. Here we show that starting only from the target sequence of the input, and freely sampling both target and binding protein conformations, RFdiffusion5 can generate binders to IDPs and IDRs in a wide rang...
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作者：Kuriyama, Shinichi
作者单位：Tohoku University
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作者：Zhong, Lin; Baptista, Scott; Gattoni, Rachel; Arnold, Jon; Flickinger, Daniel; Stringer, Carsen; Pachitariu, Marius
作者单位：Howard Hughes Medical Institute
摘要：Representation learning in neural networks may be implemented with supervised or unsupervised algorithms, distinguished by the availability of instruction. In the sensory cortex, perceptual learning drives neural plasticity1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12-13, but it is not known whether this is due to supervised or unsupervised learning. Here we recorded populations of up to 90,000 neurons simultaneously from the primary visual cortex (V1) and higher visual areas (HVAs) while mice learned...
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作者：Wang, Yu; Eapen, Vinay V.; Liang, Yaosi; Kournoutis, Athanasios; Sherman, Marc Samuel; Xu, Yanxin; Onorati, Angelique; Li, Xianting; Zhou, Xiaoting; Corey, Kathleen E.; Du, Kuo; Cabral Burkard, Ana Maria; Ho, Chia-Kang; Xie, Jing; Zhang, Hui; Maeso-Diaz, Raquel; Ma, Xinyi; Rieprecht, Ulrike; O'Brien, Tara; Cetinbas, Murat; Wang, Lu; Liu, Jihe; Bretz, Corey; Havas, Aaron P.; Zhou, Zhuo; Ho Sui, Shannan J.; Saladi, Srinivas Vinod; Sadreyev, Ruslan I.; Adams, Peter D.; Kingston, Robert E.; Diehl, Anna Mae; Alman, Benjamin; Goessling, Wolfram; Yue, Zhenyu; Wang, Xiao-Fan; Johansen, Terje; Dou, Zhixun
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; UiT The Arctic University of Tromso; Harvard University; Harvard Medical School; Duke University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Duke University; Shanghai Jiao Tong University; Duke University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Texas System; University of Texas at San Antonio; Harvard University; Harvard T.H. Chan School of Public Health; Sanford Burnham Prebys Medical Discovery Institute; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; University System of Ohio; University of Toledo; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要：Acute inflammation is an essential response that our bodies use to combat infections1. However, in the absence of infections, chronic inflammation can have a pivotal role in the onset and progression of chronic diseases, such as arthritis, cancer, autoimmune disorders, metabolic-dysfunction-associated steatohepatitis (MASH), and most ageing-associated pathologies2,3. The underlying mechanisms that distinguish chronic inflammation from its acute counterpart remain unclear, posing challenges to ...
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作者：Zhu, Yunfeng; Xiao, Fang; Wang, Yiling; Wang, Yufang; Li, Jialin; Zhong, Dongmei; Huang, Zhilei; Yu, Miao; Wang, Zhirong; Barbara, Joshua; Plunkett, Christopher; Zeng, Mengxue; Song, Yiyan; Tan, Tian; Zhang, Ruibin; Xu, Kezhen; Wang, Zhongxing; Cai, Changjie; Guan, Xiangdong; Hammack, Scott; Zhang, Liang; Shi, Zheng; Xiang, Fu-li; Shao, Feng; Xu, Jie
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作者：Garisto, Dan
