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作者：Nugent, Anya; Nugent, Peter
作者单位：Harvard University; Smithsonian Institution; Smithsonian Astrophysical Observatory; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
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作者：Calhoon, Dylan; Sang, Lingjie; Ji, Fubo; Bezwada, Divya; Hsu, Sheng-Chieh; Cai, Feng; Kim, Nathaniel; Basu, Amrita; Wu, Renfei; Pimentel, Anastasia; Brooks, Bailey; La, Konnor; Paulina Serrano, Ana; Cassidy, Daniel L.; Cai, Ling; Toffessi-Tcheuyap, Vanina; Moussa, Maryam E.; Uritboonthai, Winnie; Hoang, Linh Truc; Kolli, Meghana; Jackson, Brooklyn; Margulis, Vitaly; Siuzdak, Gary; Brugarolas, James; Corbin, Ian; Pratt, Derek A.; Weiss, Ryan J.; DeBerardinis, Ralph J.; Birsoy, Kivanc; Garcia-Bermudez, Javier
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University System of Georgia; University of Georgia; Rockefeller University; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Ottawa; Scripps Research Institute; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University System of Georgia; University of Georgia; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute
摘要：Lipids are essential components of cancer cells due to their structural and signalling roles1. To meet metabolic demands, many cancers take up extracellular lipids2, 3, 4-5; however, how these lipids contribute to cancer growth and progression remains poorly understood. Here, using functional genetic screens, we identify uptake of lipoproteins-the primary mechanism for lipid transport in circulation-as a key determinant of ferroptosis sensitivity in cancer. Lipoprotein supplementation robustly...
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作者：Feng, Rui; Fan, Kejia; Zhao, Yongjun; Qi, Zhuangzhou
作者单位：Hangzhou Normal University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
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作者：Gibney, Elizabeth
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作者：Taylor, Christopher H.; Watson, David James George; Skelhorn, John; Bell, Danny; Burdett, Simon; Codyre, Aoife; Cooley, Kathryn; Davies, James R.; Dawson, Joshua Joseph; D'Cruz, Tahire; Gandhi, Samir Raj; Jackson, Hannah J.; Lowe, Rebecca; Ogilvie, Elizabeth; Pond, Alexandra Lei; Rees, Hallie; Richardson, Joseph; Sains, Joshua; Short, Francis; Brignell, Christopher; Davidson, Gabrielle L.; Rowland, Hannah M.; East, Mark; Goodridge, Ruth; Gilbert, Francis; Reader, Tom
作者单位：University of Nottingham; Newcastle University - UK; University of Bristol; University of Nottingham; University of Cambridge; University of East Anglia; Max Planck Society; University of Liverpool; University of Nottingham
摘要：In a classic example of adaptation, harmless Batesian mimics gain protection from predators through resemblance to one or more unpalatable models1,2. Mimics vary greatly in accuracy, and explaining the persistence of inaccurate mimics is an ongoing challenge for evolutionary biologists3,4. Empirical testing of existing hypotheses is constrained by the difficulty of assessing the fitness of phenotypes absent among extant species, leaving large parts of the adaptive landscape unexplored5-a probl...
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作者：Woodley, Lucas; See, Chung Yi; Nunes, Ashley
作者单位：Harvard University
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作者：Zhu, Kun; Reid, Obadiah; Rangan, Sylvie; Wang, Li; Li, Jingbai; Durai, Kevin Antony Jesu; Zhou, Kang; Javed, Nasir; Kasaei, Leila; Yang, Chongqing; Li, Mingxing; Sun, Yue; Tan, Kui; Cotlet, Mircea; Liu, Yi; Feldman, Leonard C.; O'Carroll, Deirdre M.; Zhu, Kai; Li, Jing
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作者：Klavans, Jeremy M.; DiNezio, Pedro N.; Clement, Amy C.; Deser, Clara; Shanahan, Timothy M.; Cane, Mark A.
作者单位：University of Colorado System; University of Colorado Boulder; University of Miami; National Center Atmospheric Research (NCAR) - USA; University of Texas System; University of Texas Austin; Columbia University
摘要：The Pacific decadal oscillation (PDO)-the leading pattern of climate variability driving changes over the North Pacific and surrounding continents-is now thought to be generated by processes internal to the climate system1,2. According to this paradigm, the characteristic, irregular oscillations of the PDO arise from a collection of mechanisms involving ocean and atmosphere interactions in the North and tropical Pacific3, 4-5. Recent variations in the coupled ocean-atmosphere system, such as t...
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作者：Morez Jacobs, Adeline; Irish, Joel D.; Cooke, Ashley; Anastasiadou, Kyriaki; Barrington, Christopher; Gilardet, Alexandre; Kelly, Monica; Silva, Marina; Speidel, Leo; Tait, Frankie; Williams, Mia; Brucato, Nicolas; Ricaut, Francois-Xavier; Wilkinson, Caroline; Madgwick, Richard; Holt, Emily; Nederbragt, Alexandra J.; Inglis, Edward; Hajdinjak, Mateja; Skoglund, Pontus; Girdland-Flink, Linus
作者单位：Liverpool John Moores University; Francis Crick Institute; Francis Crick Institute; Swedish Museum of Natural History; University of London; University College London; Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Institut de Recherche pour le Developpement (IRD); Universite Federale Toulouse Midi-Pyrenees (ComUE); Institut National Polytechnique de Toulouse; Liverpool John Moores University; Cardiff University; Cardiff University; University of Aberdeen; University of Padua; RIKEN; University of Reading
摘要：Ancient Egyptian society flourished for millennia, reaching its peak during the Dynastic Period (approximately 3150-30 bce). However, owing to poor DNA preservation, questions about regional interconnectivity over time have not been addressed because whole-genome sequencing has not yet been possible. Here we sequenced a 2x coverage whole genome from an adult male Egyptian excavated at Nuwayrat (Nuerat, (sic)). Radiocarbon dated to 2855-2570 cal. bce, he lived a few centuries after Egyptian uni...
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作者：Tollefson, Jeff
