8081期

最新文章

• Excised DNA circles from V(D)J recombination promote relapsed leukaemia AI翻译
  作者：Gao, Zeqian; Scott, James N. F.; Edwards, Matthew P.; Casey, Dylan; Wang, Xiaoling; Gillen, Andrew D.; Ryan, Sarra; Russell, Lisa J.; Moorman, Anthony V.; de Tute, Ruth; Cargo, Catherine; Ford, Anthony M.; Westhead, David R.; Boyes, Joan
  作者单位：University of Leeds; Newcastle University - UK; Newcastle University - UK; Saint James's University Hospital; University of London; Royal Marsden NHS Foundation Trust; Institute of Cancer Research - UK; University of Leeds; University of Leeds; Southmead Hospital; Chinese Academy of Medical Sciences - Peking Union Medical College; Institute of Hematology & Blood Diseases Hospital - CAMS; Peking Union Medical College; University of Glasgow
  摘要：Extrachromosomal DNA amplification is associated with poor cancer prognoses1. Large numbers of excised signal circles (ESCs) are produced as by-products of antigen receptor rearrangement during V(D)J recombination2,3. However, current dogma states that ESCs are progressively lost through cell division4. Here we show that ESCs replicate and persist through many cell generations and share many properties in common with circular extrachromosomal DNAs. Increased ESC copy numbers at diagnosis of B ...
• SuFEx-based antitubercular compound irreversibly inhibits Pks13 AI翻译
  作者：Krieger, Inna V.; Sukheja, Paridhi; Yang, Baiyuan; Tang, Su; Selle, Daniel; Woods, Ashley; Engelhart, Curtis; Kumar, Pradeep; Harbut, Michael B.; Liu, Dongdong; Tsuda, Brendan; Qin, Bo; Bare, Grant A. L.; Li, Gencheng; Chi, Victor; Gambacurta, Julian; Hvizdos, Janine; Reagan, Matthew; Jones, Isabelle L.; Massoudi, Lisa M.; Woolhiser, Lisa K.; Cascioferro, Alessandro; Kundrick, Erica; Singh, Parul; Reiley, William; Ioerger, Thomas R.; Kandula, Dilipkumar Reddy; McCabe, Jacob W.; Guo, Taijie; Alland, David; Boshoff, Helena I.; Schnappinger, Dirk; Robertson, Gregory T.; Mdluli, Khisi; Lee, Kyoung-Jin; Dong, Jiajia; Li, Shuangwei; Schultz, Peter G.; Joseph, Sean B.; Love, Melissa S.; Sharpless, K. Barry; Petrassi, H. Michael; Chatterjee, Arnab K.; Sacchettini, James C.; McNamara, Case W.
  作者单位：Texas A&M University System; Texas A&M University College Station; Cornell University; Weill Cornell Medicine; Rutgers University System; Rutgers University Newark; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University System; Rutgers University Newark; Rutgers University New Brunswick; Scripps Research Institute; Trudeau Institute; Colorado State University System; Colorado State University Fort Collins; Texas A&M University System; Texas A&M University College Station; Shanghai Jiao Tong University; National Institutes of Health (NIH) - USA; Scripps Research Institute; Scripps Research Institute
  摘要：Mycobacterium tuberculosis (Mtb) remains the world's deadliest bacterial pathogen1. There is an urgent medical need to develop new drugs that shorten the treatment duration to combat widespread multi-drug-resistant and extensive-drug-resistant Mtb. Here, we present a preclinical covalent compound, CMX410, that contains an aryl fluorosulfate (SuFEx)2 warhead and uniquely targets the acyltransferase domain of Pks13, an essential enzyme in cell-wall biosynthesis. CMX410 is equipotent against drug...
• A generic non-invasive neuromotor interface for human-computer interaction AI翻译
  作者：Kaifosh, Patrick; Reardon, Thomas R.; Allen, Brian D.; Anderson, Chris; Arnoud, Sacha; Arora, Rahul; Atray, Mridu; Awad, Lana; Ayerbe, Francisco; Baker, Christopher; Baker, Nicholas; Barachant, Alexandre; Bard, Philip; Beltran, Wilman Pimentel; Berenzweig, Adam; Bhasin, Rohin; Bienkowski, Joe; Bittner, Sean; Boegner, Luke; Bolarinwa, Anu; Bosley, Don; Bracaglia, Matthew; Braecklein, Mario; Brandwein, Maclyn; Bravate, Joe; Butler, Matt; Calhoun, Adam J.; Chang, Chia-Jung; Chenet, Daniel; Chester, Joshua; Chiarito, Rudi; Chitnis, Rohan; Choi, John; Chun, Won; Chung, Jeremiah; Connors, James; Costa, Jota; Cramer, Mark; Cunningham, Raven; Cusack, William F.; Danielson, Nathan; Davidson, Thomas J.; De Araujo, Bruno; Dimaiolo, Bob; Draves, Scott; Du, Alan; Edelson, Zaina; Enemuo, Phina; Fahmi, Mina; Farsad, Nariman; Farshchian, Ali; Feliz, Randy; Fine, Jake; Formento, Emanuele; Freeman, Dustin; Fu, Jianing; Gagnon-Audet, Jean-Christophe; Gajurel, Rupesh; Gamutan, Jonathan; Gao, Sida; Garcia, Jonateal; Gayraud, Nathalie Therese Helene; Ghani, Minha; Ghosh, Sayan; Gidwani, Vickram; Giebisch, Danny; Gimler, Greg; Gramfort, Alexandre; Grosberg, Lauren; Gunther, Bryn; Guo, Ning; Gupta, Chetan; Kaya, Sinem Guven; Ha, Austin; Hadjer, Katarina; Hernandez, Carlos Xavier; Hertz, Stav; Hewitt, Carl; Hill, Daniel N.; Hong, Kirak; Hong, Lillian; Hou, Helen; Hruda, Stepan; Hsieh, Alex; Hsiung, Vivian; Huang, Rongqing; Hui, Yue; Hulet, Hazel; Islam, Shaker; Jayaram, Vinay; Jiang, Connie; Jiang, Xiaodong; Juarez, Brooke; Jun, James Jaeyoon; Jun, Na Young; Kadakia, Nirag; Kakar, Nishant; Kamdar, Ajay; Kao, Ta-Chu; Kober, Steven; Koh, Tw; Koshy, Christina Shabu; Lawn, Andrzej; Lee, Claire; Lee, Jennifer; Lee, Jinhyung; Lee, Juheui Amy; Li, Tiffanie; Liao, Jonathan; Liu, Yingru; Liu, Yuxuan; Lively, Saar; London, Kati; Louie, Roddy; Luongo, Francisco; Maczak, Attila; Maheswaranathan, Niru; Mandel, Michael; Marshall, Jesse; Marshall, Najja; Martincik, Mirek; Masse, Nicolas Yvan; McAnearney, Stephen; McHugh, Ashley; Menendez, Jorge Aurelio; Merel, Josh; Miller, David; Milyavskiy, Ilya; Monti, Ricardo Pio; Moore, Sean; Morin, Yonathan; Morrell, Brock; Morrison, Dano; Moschella, Anthony; Mulumudi, Suman; Muth, Conner; Naik, Krunal; Nakagaki, Norris; Nathan, Ajay; Nelson, Romario; Ngeo, Jimson; Nguyen, Keven; O'Connor, Luke; Ohayon, Shay; Orchard, Garrick; Osborn, Chris; Otchy, Timothy M.; Owolabi, Emmanuella; Packer, Adam M.; Pailla, Tejaswy; Paredes, Julia; Parker, Sean; Peixoto, Diogo; Perez, Matias; Perez, Zavion; Pierard, Adrien; Plaza, Stephen M.; Plotkin, Natalie; Pnevmatikakis, Eftychios; Pool, Brandon; Puri, Shanil; Rajani, Sunaina; Fuentes, Jose Ramirez; Rojas, Julian Ramos; Ranjan, Tanvi; Reardon, Devin; Reid, Jonathan; Reisman, Jason; Rivera, Lain Warawao Nemo Mora y; Rolotti, Sebi; Rosenkranz, Andrew; Roth, Ian; Roy, Likhon; Rubin, Ran; Rudnicki, Alexander; Russell, Sam; Russo, Abby; Sacra, James; Sadoughi, Amir; Salim, Roxanna; Savane, Aichatou; Schlager, Collin; Schwab, David; Seely, Jeffrey; Seltzer, Mike; Sergin, Nurettin Dorukhan; Shah, Ami; Shah, Anish; Shamash, Philip; Sharma, Vandita; Shen, Stephie; Shi, Kevin; Shiah, Olivia; Siahpoosh, Yasmin; Siddiqi, Noor; Simpson, Jeremy; Singh, Gagandip; Sivakumar, Viswanath; Smith, Jeff; Sofuoglu, Seyyid Emre; Song, Ivy Jiyoung; Springer, Morgan; Spurr, Adrian; Stefanini, Fabio; Stout, Connor; Strauss, Emanuel; Suresh, Swetha; Suri, Ananya; Sussillo, David; Tang, Ziyi; Tank, Vikram; Tannady, Jesslyn; Tapia, Aliqyan; Tasci, Tugce; Tesileanu, Tiberiu; Tiwari, Aman; Tiwari, Anoushka; Tong, Calvin; Tormis, Blizelle; Trabulsi, Julia; Tsering, Migmar; Urquhart, Kyle; Walkington, Peter; Wang, Megan; Wang, Renxiong; Wang, Zhuo; Warden, Christy; Warren, Richard; Warriner, Claire L.; Weiss, Ron J.; Wetmore, Daniel Z.; White, Ezri; Wiebe, Christopher; Williams, Steve; Xing, Yuguan; Ye, Chris; Yembarwar, Akshay; Yuan, Shuibenyang; Zawadzki, Michael; Zhang, Mingrui; Zhao, Jiesi; Zheng, Kevin; Zhong, Joseph; Zhou, Lei; Zlobinsky, Danny
  摘要：Since the advent of computing, humans have sought computer input technologies that are expressive, intuitive and universal. While diverse modalities have been developed, including keyboards, mice and touchscreens, they require interaction with a device that can be limiting, especially in on-the-go scenarios. Gesture-based systems use cameras or inertial sensors to avoid an intermediary device, but tend to perform well only for unobscured movements. By contrast, brain-computer or neuromotor int...
• First CRISPR horses spark controversy: what's next for gene-edited animals? AI翻译
  作者：Kavanagh, Katie
• RNA N-glycosylation enables immune evasion and homeostatic efferocytosis AI翻译
  作者：Graziano, Vincent R.; Porat, Jennifer; Ah Kioon, Marie Dominique; Mejdrova, Ivana; Matz, Alyssa J.; Lebedenko, Charlotta G.; Chai, Peiyuan; Pluvinage, John V.; Ricci-Azevedo, Rafael; Harrison, Andrew G.; Wright, Skylar S.; Wang, Xinzheng; Strine, Madison S.; Wang, Penghua; Wilson, Michael R.; Vanaja, Sivapriya Kailasan; Zhou, Beiyan; Barrat, Franck J.; Carell, Thomas; Flynn, Ryan A.; Rathinam, Vijay A.
  作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; University of Munich; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Yale University; University of Connecticut; Cornell University; Weill Cornell Medicine; Harvard University; Harvard University
  摘要：Glycosylation is central to the localization and function of biomolecules1. We recently discovered that small RNAs undergo N-glycosylation2 at the modified RNA base 3-(3-amino-3-carboxypropyl) uridine (acp3U)3. However, the functional significance of N-glycosylation of RNAs is unknown. Here we show that the N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs. We found that de-N-glycosylation of cell-culture-derived and circulating human and mouse glycoRNA elicited pot...
• Flourishing chemosynthetic life at the greatest depths of hadal trenches AI翻译
  作者：Peng, Xiaotong; Du, Mengran; Gebruk, Andrey; Liu, Shuangquan; Gao, Zhaoming; Glud, Ronnie N.; Zhou, Peng; Wang, Ruoheng; Rowden, Ashley A.; Kamenev, Gennady M.; Maiorova, Anastassya S.; Papineau, Dominic; Chen, Shun; Gao, Jinwei; Liu, Helu; He, Yuan; Alalykina, Inna L.; Dolmatov, Igor Yu.; Zhang, Hanyu; Li, Xuegong; Malyutina, Marina V.; Dasgupta, Shamik; Saulenko, Anastasiia A.; Shilov, Vladimir A.; Liu, Shuting; Xie, Tongtong; Qu, Yuangao; Song, Xikun; Zhang, Haibin; Liu, Hao; Zhang, Weijia; Huang, Xiaoxia; Xu, Hongzhou; Xu, Wenjing; Mordukhovich, Vladimir V.; Adrianov, Andrey V.
  作者单位：Chinese Academy of Sciences; Institute of Deep-Sea Science & Engineering, CAS; Russian Academy of Sciences; Shirshov Institute of Oceanology; University of Southern Denmark; Earth Sciences New Zealand; National Institute of Water & Atmospheric Research (NIWA) - New Zealand; Victoria University Wellington; Russian Academy of Sciences; National Scientific Center of Marine Biology, Far East Branch of the Russian Academy of Sciences
  摘要：Hadal trenches, some of the Earth's least explored and understood environments, have long been proposed to harbour chemosynthesis-based communities1,2. Despite increasing attention, actual documentation of such communities has been exceptionally rare3,4. Here we report the discovery of the deepest and the most extensive chemosynthesis-based communities known to exist on Earth during an expedition to the Kuril-Kamchatka Trench and the western Aleutian Trench using the manned submersible Fendouz...
• These nations are wooing PhD students amid US funding uncertainties AI翻译
  作者：Fieldhouse, Rachel
• Novel assembly of a head-trunk interface in the sister group of jawed vertebrates AI翻译
  作者：Miyashita, Tetsuto; Janvier, Philippe; Tietjen, Kristen; Berenguer, Felisa; Schoder, Sebastian; Marone, Federica; Gueriau, Pierre; Coates, Michael I.
  作者单位：University of Ottawa; Museum National d'Histoire Naturelle (MNHN); University of Kansas; University of Kansas; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Museum National d'Histoire Naturelle (MNHN); SOLEIL Synchrotron; Swiss Federal Institutes of Technology Domain; Paul Scherrer Institute; University of Lausanne; University of Chicago
  摘要：The standard scenario for the origin of jawed vertebrates depicts a transition from benthic grazers to nektonic predators1, 2-3, facilitated by a suite of anatomical innovations, including elaborate sensory systems, a high-flow heart and the integration of jaw-opening muscles with the craniothoracic hinge4, 5, 6-7. However, the lamprey-like internal anatomy8, 9, 10, 11, 12-13 reconstructed for osteostracans, the sister group of jawed vertebrates, seem to lack these gnathostome traits, implying...
• Endophilin marks and controls a clathrin-independent endocytic pathway ( vol 517, pg460-465 2015) AI翻译
  作者：Boucrot, Emmanuel; Ferreira, Antonio P. A.; Almeida-Souza, Leonardo; Debard, Sylvain; Vallis, Yvonne; Howard, Gillian; Bertot, Laetitia; Sauvonnet, Nathalie; McMahon, Harvey T.
• Two-billion-year transitional oxygenation of the Earth's surface AI翻译
  作者：Wang, Haiyang; Li, Chao; Peng, Yongbo; Zhang, Junpeng; Cheng, Meng; Cao, Xiaobin; Qie, Wenkun; Zhang, Zihu; Dodd, Matthew S.; Hou, Mingcai; Wallace, Malcolm; V. S. Hood, Ashleigh; Lyons, Timothy W.; Bao, Huiming
  作者单位：Chengdu University of Technology; Nanjing University; Ministry of Natural Resources of the People's Republic of China; Chengdu University of Technology; Chengdu University of Technology; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; University of Western Australia; University of Melbourne; University of California System; University of California Riverside
  摘要：Earth's surface underwent stepwise oxygenation before persistently reaching modern levels late in its history1, 2, 3, 4-5, but the details of this transition remain unclear5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15-16. Here we present a high-resolution 2.5-Gyr record of mass-independent oxygen isotopes in sedimentary sulfate (Delta ' 17Osulfate), a proxy linked to the atmospheric partial pressure of O2 (pO2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts}...