8081期

最新文章

• 'Amazing feat': US man still alive six months after pig kidney transplant AI翻译
  作者：Fieldhouse, Rachel
• WILL AI EVER STOP MAKING UP CITATIONS? GPT-5 OFFERS HOPE AI翻译
  作者：Gibney, Elizabeth
• A population plunge could help to mitigate the global biodiversity crisis AI翻译
  作者：Hayward, Matt W.; Williams, Brooke; Mcbain, Bonnie
  作者单位：University of Newcastle
• Fluctuating DNA methylation tracks cancer evolution at clinical scale AI翻译
  作者：Gabbutt, Calum; Duran-Ferrer, Marti; Grant, Heather E.; Mallo, Diego; Nadeu, Ferran; Househam, Jacob; Villamor, Neus; Mueller, Madlen; Heath, Simon; Raineri, Emanuele; Krali, Olga; Nordlund, Jessica; Zenz, Thorsten; Gut, Ivo G.; Campo, Elias; Lopez-Guillermo, Armando; Fitzgibbon, Jude; Barnes, Chris P.; Shibata, Darryl; Martin-Subero, Jose I.; Graham, Trevor A.
  作者单位：Royal Marsden NHS Foundation Trust; University of London; Institute of Cancer Research - UK; Imperial College London; University of London; Queen Mary University London; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; CIBER - Centro de Investigacion Biomedica en Red; CIBERONC; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; University of Barcelona; Hospital Clinic de Barcelona; Uppsala University; University of Zurich; University Zurich Hospital; University of Zurich; University of Barcelona; University of London; University College London; University of Southern California; ICREA
  摘要：Cancer development and response to treatment are evolutionary processes1,2, but characterizing evolutionary dynamics at a clinically meaningful scale has remained challenging3. Here we develop a new methodology called EVOFLUx, based on natural DNA methylation barcodes fluctuating over time4, that quantitatively infers evolutionary dynamics using only a bulk tumour methylation profile as input. We apply EVOFLUx to 1,976 well-characterized lymphoid cancer samples spanning a broad spectrum of dis...
• Long-range PM2.5 pollution and health impacts from the 2023 Canadian wildfires AI翻译
  作者：Zhang, Qiang; Wang, Yuexuanzi; Xiao, Qingyang; Geng, Guannan; Davis, Steven J.; Liu, Xiaodong; Yang, Jin; Liu, Jiajun; Huang, Wenyu; He, Changpei; Luo, Binhe; Martin, Randall V.; Brauer, Michael; Randerson, James T.; He, Kebin
  作者单位：Tsinghua University; Tsinghua University; Stanford University; Beijing Normal University; Washington University (WUSTL); University of British Columbia; Institute for Health Metrics & Evaluation; University of Washington; University of Washington Seattle; University of California System; University of California Irvine
  摘要：Smoke from extreme wildfires in Canada adversely affected air quality in many regions in 20231,2. Here we use satellite observations, machine learning and a chemical transport model to quantify global and regional PM2.5 (particulate matter less than 2.5 mu m in diameter) exposure and human health impacts related to the 2023 Canadian wildfires. We find that the fires increased annual PM2.5 exposure worldwide by 0.17 mu g m-3 (95% confidence interval, 0.09-0.26 mu g m-3). North America had the l...
• Equity in science is a beautiful lie - and I'm done pretending AI翻译
  作者：Armenteras, Dolors
  作者单位：Universidad Nacional de Colombia
• Macrophages excite muscle spindles with glutamate to bolster locomotion (vol 637, pages698-707 (2025)) AI翻译
  作者：Yan, Yuyang; Antolin, Nuria; Zhou, Luming; Xu, Luyang; Vargas, Irene Lisa; Gomez, Carlos Daniel; Kong, Guiping; Palmisano, Ilaria; Yang, Yi; Chadwick, Jessica; Mueller, Franziska; Bull, Anthony M. J.; Lo Celso, Cristina; Primiano, Guido; Servidei, Serenella; Perrier, Jean Francois; Bellardita, Carmelo; Di Giovanni, Simone
• Coordinate to combat Pakistan's climate-driven disasters AI翻译
  作者：Khan, Raees; Liu, Jie
  作者单位：Chinese Academy of Sciences; Kunming Institute of Botany, CAS
• Dual neuromodulatory dynamics underlie birdsong learning (vol 641, pg 690, 2025) AI翻译
  作者：Qi, Jiaxuan; Schreiner, Drew C.; Martinez, Miles; Pearson, John; Mooney, Richard
• Lithium deficiency and the onset of Alzheimer's disease AI翻译
  作者：Aron, Liviu; Ngian, Zhen Kai; Qiu, Chenxi; Choi, Jaejoon; Liang, Marianna; Drake, Derek M.; Hamplova, Sara E.; Lacey, Ella K.; Roche, Perle; Yuan, Monlan; Hazaveh, Saba S.; Lee, Eunjung A.; Bennett, David A.; Yankner, Bruce A.
  作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Rush University
  摘要：The earliest molecular changes in Alzheimer's disease (AD) are poorly understood1, 2, 3, 4-5. Here we show that endogenous lithium (Li) is dynamically regulated in the brain and contributes to cognitive preservation during ageing. Of the metals we analysed, Li was the only one that was significantly reduced in the brain in individuals with mild cognitive impairment (MCI), a precursor to AD. Li bioavailability was further reduced in AD by amyloid sequestration. We explored the role of endogenou...