8081期

最新文章

• 'LIPSTICK ON A PIG': HOW TO HANDLE PEER-REVIEW BULLIES AI翻译
  作者：Zimmer, Katarina
• Songs of the striped mouse show who's friend and who's foe AI翻译
  作者：[Anonymous]
• Bioelectronic implants built from rolled-up stretchy circuits AI翻译
  作者：Lee, Hyunjin; Kim, Dae-Hyeong
  作者单位：Institute for Basic Science - Korea (IBS); Seoul National University (SNU)
• Controversial New Alzheimer's Drugs Offer Hope-But at a High Cost AI翻译
  作者：Seegert, Liz
• Chemists cram record nine metals into trendy 2D material AI翻译
  作者：Bourzac, Katherine
• High-density soft bioelectronic fibres for multimodal sensing and stimulation AI翻译
  作者：Khatib, Muhammad; Zhao, Eric Tianjiao; Wei, Shiyuan; Park, Jaeho; Abramson, Alex; Bishop, Estelle Spear; Thomas, Anne-Laure; Chen, Chih-Hsin; Emengo, Pamela; Xu, Chengyi; Hamnett, Ryan; Root, Samuel E.; Yuan, Lei; Wurdack, Matthias J.; Zaluska, Tomasz; Lee, Yeongjun; Parkatzidis, Kostas; Yu, Weilai; Chakhtoura, Dorine; Kim, Kyun Kyu; Zhong, Donglai; Nishio, Yuya; Zhao, Chuanzhen; Wu, Can; Jiang, Yuanwen; Zhang, Anqi; Li, Jinxing; Wang, Weichen; Salimi-Jazi, Fereshteh; Rafeeqi, Talha A.; Hemed, Nofar Mintz; Tok, Jeffrey B. -H.; Qian, Xiang; Chen, Xiaoke; Kaltschmidt, Julia A.; Dunn, James C. Y.; Bao, Zhenan
  作者单位：Stanford University; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; Emory University; Stanford University; Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Stanford University; Stanford University; Stanford University; Michigan State University; Michigan State University; Stanford University; Stanford University; Stanford Medicine; Stanford University
  摘要：There is an increasing demand for multimodal sensing and stimulation bioelectronic fibres for both research and clinical applications1,2. However, existing fibres suffer from high rigidity, low component layout precision, limited functionality and low density of active components. These limitations arise from the challenge of integrating many components into one-dimensional fibre devices, especially owing to the incompatibility of conventional microfabrication methods (for example, photolithog...
• Coordinate to combat Pakistan's climate-driven disasters AI翻译
  作者：Khan, Raees; Liu, Jie
  作者单位：Chinese Academy of Sciences; Kunming Institute of Botany, CAS
• Dual neuromodulatory dynamics underlie birdsong learning (vol 641, pg 690, 2025) AI翻译
  作者：Qi, Jiaxuan; Schreiner, Drew C.; Martinez, Miles; Pearson, John; Mooney, Richard
• Lithium deficiency and the onset of Alzheimer's disease AI翻译
  作者：Aron, Liviu; Ngian, Zhen Kai; Qiu, Chenxi; Choi, Jaejoon; Liang, Marianna; Drake, Derek M.; Hamplova, Sara E.; Lacey, Ella K.; Roche, Perle; Yuan, Monlan; Hazaveh, Saba S.; Lee, Eunjung A.; Bennett, David A.; Yankner, Bruce A.
  作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Rush University
  摘要：The earliest molecular changes in Alzheimer's disease (AD) are poorly understood1, 2, 3, 4-5. Here we show that endogenous lithium (Li) is dynamically regulated in the brain and contributes to cognitive preservation during ageing. Of the metals we analysed, Li was the only one that was significantly reduced in the brain in individuals with mild cognitive impairment (MCI), a precursor to AD. Li bioavailability was further reduced in AD by amyloid sequestration. We explored the role of endogenou...
• Structural and functional characterization of human sweet taste receptor AI翻译
  作者：Shi, Zongjun; Xu, Weixiu; Wu, Lijie; Yue, Xiaolei; Liu, Shenhui; Ding, Wei; Zhang, Jinyi; Meng, Bing; Zhao, Lianghao; Liu, Xiaoyan; Liu, Junlin; Liu, Zhi-Jie; Hua, Tian
  作者单位：ShanghaiTech University; ShanghaiTech University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Physics, CAS
  摘要：Sweet taste perception influences dietary choices and metabolic health. The human sweet taste receptor, a class C G-protein-coupled receptor (GPCR) heterodimer composed of TAS1R2 and TAS1R3 (refs. 1,2), senses a wide range of sweet compounds-including natural sugars, artificial sweeteners and sweet proteins-and affects metabolic regulation beyond taste. However, the lack of three-dimensional structures hinders our understanding of its precise working mechanism. Here we present cryo-electron mi...