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作者:Zimmer, Katarina
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作者:[Anonymous]
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作者:Lee, Hyunjin; Kim, Dae-Hyeong
作者单位:Institute for Basic Science - Korea (IBS); Seoul National University (SNU)
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作者:Seegert, Liz
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作者:Bourzac, Katherine
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作者:Khatib, Muhammad; Zhao, Eric Tianjiao; Wei, Shiyuan; Park, Jaeho; Abramson, Alex; Bishop, Estelle Spear; Thomas, Anne-Laure; Chen, Chih-Hsin; Emengo, Pamela; Xu, Chengyi; Hamnett, Ryan; Root, Samuel E.; Yuan, Lei; Wurdack, Matthias J.; Zaluska, Tomasz; Lee, Yeongjun; Parkatzidis, Kostas; Yu, Weilai; Chakhtoura, Dorine; Kim, Kyun Kyu; Zhong, Donglai; Nishio, Yuya; Zhao, Chuanzhen; Wu, Can; Jiang, Yuanwen; Zhang, Anqi; Li, Jinxing; Wang, Weichen; Salimi-Jazi, Fereshteh; Rafeeqi, Talha A.; Hemed, Nofar Mintz; Tok, Jeffrey B. -H.; Qian, Xiang; Chen, Xiaoke; Kaltschmidt, Julia A.; Dunn, James C. Y.; Bao, Zhenan
作者单位:Stanford University; University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; Emory University; Stanford University; Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Stanford University; Stanford University; Stanford University; Michigan State University; Michigan State University; Stanford University; Stanford University; Stanford Medicine; Stanford University
摘要:There is an increasing demand for multimodal sensing and stimulation bioelectronic fibres for both research and clinical applications1,2. However, existing fibres suffer from high rigidity, low component layout precision, limited functionality and low density of active components. These limitations arise from the challenge of integrating many components into one-dimensional fibre devices, especially owing to the incompatibility of conventional microfabrication methods (for example, photolithog...
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作者:Khan, Raees; Liu, Jie
作者单位:Chinese Academy of Sciences; Kunming Institute of Botany, CAS
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作者:Qi, Jiaxuan; Schreiner, Drew C.; Martinez, Miles; Pearson, John; Mooney, Richard
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作者:Aron, Liviu; Ngian, Zhen Kai; Qiu, Chenxi; Choi, Jaejoon; Liang, Marianna; Drake, Derek M.; Hamplova, Sara E.; Lacey, Ella K.; Roche, Perle; Yuan, Monlan; Hazaveh, Saba S.; Lee, Eunjung A.; Bennett, David A.; Yankner, Bruce A.
作者单位:Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Rush University
摘要:The earliest molecular changes in Alzheimer's disease (AD) are poorly understood1, 2, 3, 4-5. Here we show that endogenous lithium (Li) is dynamically regulated in the brain and contributes to cognitive preservation during ageing. Of the metals we analysed, Li was the only one that was significantly reduced in the brain in individuals with mild cognitive impairment (MCI), a precursor to AD. Li bioavailability was further reduced in AD by amyloid sequestration. We explored the role of endogenou...
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作者:Shi, Zongjun; Xu, Weixiu; Wu, Lijie; Yue, Xiaolei; Liu, Shenhui; Ding, Wei; Zhang, Jinyi; Meng, Bing; Zhao, Lianghao; Liu, Xiaoyan; Liu, Junlin; Liu, Zhi-Jie; Hua, Tian
作者单位:ShanghaiTech University; ShanghaiTech University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Physics, CAS
摘要:Sweet taste perception influences dietary choices and metabolic health. The human sweet taste receptor, a class C G-protein-coupled receptor (GPCR) heterodimer composed of TAS1R2 and TAS1R3 (refs. 1,2), senses a wide range of sweet compounds-including natural sugars, artificial sweeteners and sweet proteins-and affects metabolic regulation beyond taste. However, the lack of three-dimensional structures hinders our understanding of its precise working mechanism. Here we present cryo-electron mi...