作者：Carss, Keren; Halldorsson, Bjarni V.; Hou, Liping; Liu, Jimmy; Wheeler, Eleanor; Lo, Yancy; Kundu, Kousik; Huang, Zhuoyi; Ben Lacey, Ben; Dhindsa, Ryan S.; Rajan, Diana; Randjelovic, Jelena; Marriott, Neil; Scott, Carol E.; Yavuz, Ahmet Sinan; Johnston, Ian; Howe, Trevor; Black, Mary Helen; Stefansson, Kari; Scott, Robert; Petrovski, Slave; Li, Shuwei; Cortes, Adrian; Hu, Fengyuan; Wang, Quanli; Burren, Oliver S.; Deevi, Sri V. V.; Haefliger, Carolina; Lythgow, Kieren; Maccallum, Peter H.; Megy, Karyn; Mitchell, Jonathan; O'Dell, Sean; O'Neill, Amanda; Smith, Katherine R.; Taiy, Haeyam; Pangalos, Menelas; March, Ruth; Wasilewski, Sebastian; Eggertsson, Hannes P.; Moore, Kristjan H. S.; Hauswedell, Hannes; Eiriksson, Ogmundur; Skaftason, Aron; Gislason, Nokkvi; Sigurjonsdottir, Svanhvit; Ulfarsson, Magnus O.; Palsson, Gunnar; Hardarson, Marteinn T.; Oddsson, Asmundur; Jensson, Brynjar O.; Kristmundsdottir, Snaedis; Sigurpalsdottir, Brynja D.; Stefansson, Olafur A.; Beyter, Doruk; Holley, Guillaume; Tragante, Vinicius; Gylfason, Arnaldur; Olason, Pall I.; Zink, Florian; Asgeirsdottir, Margret; Sverrisson, Sverrir T.; Sigurdsson, Brynjar; Gudjonsson, Sigurjon A.; Sigurdsson, Gunnar T.; Halldorsson, Gisli H.; Sveinbjornsson, Gardar; Styrkarsdottir, Unnur; Magnusdottir, Droplaug N.; Snorradottir, Steinunn; Kristinsson, Kari; Sobech, Emilia; Thorleifsson, Gudmar; Jonsson, Frosti; Melsted, Pall; Jonsdottir, Ingileif; Rafnar, Thorunn; Holm, Hilma; Stefansson, Hreinn; Saemundsdottir, Jona; Gudbjartsson, Daniel F.; Magnusson, Olafur T.; Masson, Gisli; Thorsteinsdottir, Unnur; Helgason, Agnar; Jonsson, Hakon; Sulem, Patrick; Sandhuria, Jatin; Richardson, Tom G.; Howe, Laurence; Robins, Chloe; Liu, Dongjing; Albers, Patrick; Pereira, Mariana; Seaton, Daniel; Aulchenko, Yury; Whittaker, John; Dermitzakis, Manolis; Johnson, Toby; Davitte, Jonathan; Ingelsson, Erik; Molineros, Julio; Zhang, Yanfei; Li, Alexander H.; Baugh, Evan H.; Mlynarski, Elisabeth; Torshizi, Abolfazl Doostparast; Abdel-Azim, Gamal; Mautz, Brian; He, Karen Y.; Xi, Jingyue; Nieves-Rodriguez, Shirley; Khan, Asif; Xu, Songjun; Liu, Xingjun; Sarver, Brice; Truong, Dongnhu; Temanni, Mohamed-Ramzi; Whelan, Christopher D.; Goretti, Letizia; Khan, Najat; Fraile, Belen; Mansi, Tommaso; Rajagopal, Guna; Akhtar, Shaheen; Austin-Guest, Siobhan; Barber, Robert; Barrett, Daniel; Bellerby, Tristram; Clarke, Adrian; Clark, Richard; Coppola, Maria; Cornwell, Linda; Crackett, Abby; Dawson, Joseph; Day, Callum; Dove, Alexander; Durham, Jillian; Fairweather, Robert; Ferrero, Marcella; Fenton, Michael; Fordham, Howerd; Fraser, Audrey; Heath, Paul; Heron, Emily; Hornett, Gary; Hughes-Hallett, Lena; Jackson, David K.; Jakubowski Smith, Alexander; Laverack, Adam; Law, Katharine; Leonard, Steven R.; Lewis, Kevin; Liddle, Jennifer; Lindsell, Alice; Linsdell, Sally; Lovell, Jamie; Mack, James; Mallalieu, Henry; Mamun, Irfaan; Monteiro, Ana; Morrow, Leanne; Pardubska, Barbora; Popov, Alexandru; Sloper, Lisa; Squares, Jan; Still, Ian; Taylor, Oprah; Taylor, Sam; Tovar Corona, Jaime M.; Trigg, Elliott; Vancollie, Valerie; Voak, Paul; Weldon, Danni; Wells, Alan; Wells, Eloise; Williams, Mia; Wright, Sean; Miletic, Nevena; Lenhardt Ackovic, Lea; Slavkovic-Ilic, Marijeta; Lazarevic, Mladen; Aigrain, Louise; Redshaw, Nicholas; Quail, Michael; Shirley, Lesley; Thurston, Scott; Ellis, Peter; Grout, Laura; Smerdon, Natalie; Gray, Emma; Rance, Richard; Langford, Cordelia; Collins, Rory; Effingham, Mark; Allen, Naomi; Sellors, Jonathan; Sheard, Simon; Pancholi, Mahesh; Clark, Caroline; Burkitt-Gray, Lucy; Welsh, Samantha; Fry, Daniel; Watson, Rachel; Carson, Lauren; Young, Alan; Mehio, Rami; Schulz-Trieglaff, Ole
作者单位：AstraZeneca; Reykjavik University; Johnson & Johnson; Janssen Pharmaceuticals; GlaxoSmithKline; Glaxosmithkline USA; Illumina; AstraZeneca; Wellcome Trust Sanger Institute; University of Iceland; GlaxoSmithKline; Glaxosmithkline United Kingdom; GlaxoSmithKline; AstraZeneca; AstraZeneca; University of Iceland; University of Iceland; Johnson & Johnson; Janssen Pharmaceuticals; Johnson & Johnson; Johnson & Johnson USA; Janssen Biotech Inc; Johnson & Johnson; Janssen Pharmaceuticals; Illumina; Illumina; MRC Biostatistics Unit; University of Cambridge
摘要：Whole-genome sequencing provides an unbiased and complete view of the human genome and enables the discovery of genetic variation without the technical limitations of other genotyping technologies. Here we report on whole-genome sequencing of 490,640 UK Biobank participants, building on previous genotyping effort1. This advance deepens our understanding of how genetics associates with disease biology and further enhances the value of this open resource for the study of human biology and health...
作者：Liu, Winston W.; Reicher, Naama; Alway, Emily; Rupprecht, Laura E.; Weng, Peter; Schaefgen, Chloe; Klein, Marguerita E.; Villalobos, Jorge A.; Puerto-Hernandez, Carlos; Kiesling Altun, Yolanda Graciela; Carbajal, Amanda; Aguayo-Guerrero, Jose Alfredo; Coss, Alam; Sahasrabudhe, Atharva; Anikeeva, Polina; de Araujo, Alan; Bali, Avnika; de Lartigue, Guillaume; Gil-Lievana, Elvi; Gutierrez, Ranier; Miao, Edward A.; Rawls, John F.; Kaelberer, M. Maya; Bohorquez, Diego V.
作者单位：Duke University; Duke University; Duke University; Duke University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Monell Chemical Senses Center; University of Pennsylvania; Pennsylvania Medicine; Instituto Politecnico Nacional - Mexico; CINVESTAV - Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional; Instituto Politecnico Nacional - Mexico; CINVESTAV - Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional; Duke University; Duke University; Duke University; Duke University; University of Arizona; University of Arizona Health Sciences; Duke University; Stanford Medicine; Stanford University
摘要：To coexist with its resident microorganisms, the host must have a sense to adjust its behaviour in response to them. In the intestine, a sense for nutrients transduced to the brain through neuroepithelial circuits guides appetitive choices1, 2, 3, 4-5. However, a sense that allows the host to respond in real time to stimuli arising from resident gut microorganisms remains to be uncovered. Here we show that in the mouse colon, the ubiquitous microbial pattern flagellin-a unifying feature across...
作者：Gabbutt, Calum; Duran-Ferrer, Marti; Grant, Heather E.; Mallo, Diego; Nadeu, Ferran; Househam, Jacob; Villamor, Neus; Mueller, Madlen; Heath, Simon; Raineri, Emanuele; Krali, Olga; Nordlund, Jessica; Zenz, Thorsten; Gut, Ivo G.; Campo, Elias; Lopez-Guillermo, Armando; Fitzgibbon, Jude; Barnes, Chris P.; Shibata, Darryl; Martin-Subero, Jose I.; Graham, Trevor A.
作者单位：Royal Marsden NHS Foundation Trust; University of London; Institute of Cancer Research - UK; Imperial College London; University of London; Queen Mary University London; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; CIBER - Centro de Investigacion Biomedica en Red; CIBERONC; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; University of Barcelona; Hospital Clinic de Barcelona; Uppsala University; University of Zurich; University Zurich Hospital; University of Zurich; University of Barcelona; University of London; University College London; University of Southern California; ICREA
摘要：Cancer development and response to treatment are evolutionary processes1,2, but characterizing evolutionary dynamics at a clinically meaningful scale has remained challenging3. Here we develop a new methodology called EVOFLUx, based on natural DNA methylation barcodes fluctuating over time4, that quantitatively infers evolutionary dynamics using only a bulk tumour methylation profile as input. We apply EVOFLUx to 1,976 well-characterized lymphoid cancer samples spanning a broad spectrum of dis...
