作者：Lutsik, Pavlo; Manojlovic, Veselin; Vassiliou, George S.
作者单位：KU Leuven; University of Cambridge
作者：Li, Zhiqian; Dong, Yuemei; You, Lang; Corder, Rodrigo M.; Arzobal, Jemariz; Yeun, Audrey; Yang, Lei; Marshall, John M.; Dimopoulos, George; Bier, Ethan
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Universidade Estadual de Campinas; Universidade de Sao Paulo; Institute Biomed Science, University Sao Paulo; University of California System; University of California Berkeley
摘要：Malaria remains a substantial global health challenge, causing approximately half a million deaths each year1. The mosquito fibrinogen-related protein 1 (FREP1) is required for malaria parasites to infect the midgut epithelium2. The naturally occurring FREP1Q allele has been reported to prevent parasite infection, while supporting essential physiological functions in the mosquito3. Here we generate congenic strains of Anopheles stephensi, edited to carry either the parasite-susceptible FREP1L2...
作者：Sarnataro, Raffaele; Velasco, Cecilia D.; Monaco, Nicholas; Kempf, Anissa; Miesenbock, Gero
作者单位：University of Oxford; University of Basel
摘要：To gain a comprehensive, unbiased perspective on molecular changes in the brain that may underlie the need for sleep, we have characterized the transcriptomes of single cells isolated from rested and sleep-deprived flies. Here we report that transcripts upregulated after sleep deprivation, in sleep-control neurons projecting to the dorsal fan-shaped body1,2 (dFBNs) but not ubiquitously in the brain, encode almost exclusively proteins with roles in mitochondrial respiration and ATP synthesis. T...
作者：Yan, Yuyang; Antolin, Nuria; Zhou, Luming; Xu, Luyang; Vargas, Irene Lisa; Gomez, Carlos Daniel; Kong, Guiping; Palmisano, Ilaria; Yang, Yi; Chadwick, Jessica; Mueller, Franziska; Bull, Anthony M. J.; Lo Celso, Cristina; Primiano, Guido; Servidei, Serenella; Perrier, Jean Francois; Bellardita, Carmelo; Di Giovanni, Simone
作者：Jin, Feitong; Jiang, Si; Zhu, Xuhao; Bao, Zehang; Shen, Fanhao; Wang, Ke; Zhu, Zitian; Xu, Shibo; Song, Zixuan; Chen, Jiachen; Tan, Ziqi; Wu, Yaozu; Zhang, Chuanyu; Gao, Yu; Wang, Ning; Zou, Yiren; Zhang, Aosai; Li, Tingting; Zhong, Jiarun; Cui, Zhengyi; Han, Yihang; He, Yiyang; Wang, Han; Yang, Jia-Nan; Wang, Yanzhe; Shen, Jiayuan; Liu, Gongyu; Deng, Jinfeng; Dong, Hang; Zhang, Pengfei; Li, Weikang; Yuan, Dong; Lu, Zhide; Sun, Zheng-Zhi; Li, Hekang; Zhang, Junxiang; Song, Chao; Wang, Zhen; Guo, Qiujiang; Machado, Francisco; Kemp, Jack; Iadecola, Thomas; Yao, Norman Y.; Wang, H.; Deng, Dong-Ling
作者单位：Zhejiang University; Zhejiang University; Tsinghua University; Shanghai Qi Zhi Institute; Leiden University; Leiden University - Excl LUMC; Hefei National Laboratory; Harvard University; Smithsonian Astrophysical Observatory; Smithsonian Institution; Harvard University; University of Cambridge; Iowa State University; United States Department of Energy (DOE); Ames National Laboratory
摘要：Symmetry-protected topological phases1, 2, 3-4 cannot be described by any local order parameter and are beyond the conventional symmetry-breaking model5. They are characterized by topological boundary modes that remain stable under symmetry respecting perturbations1, 2, 3-4,6, 7-8. In clean, gapped systems without disorder, the stability of these edge modes is restricted to the zero-temperature manifold; at finite temperatures, interactions with mobile thermal excitations lead to their decay9,...
