8082期

最新文章

• Robot-assisted mapping of chemical reaction hyperspaces and networks AI翻译
  作者：Jia, Yankai; Frydrych, Rafal; Sobolev, Yaroslav I.; Wong, Wai-Shing; Prajapati, Bibek; Matuszczyk, Daniel; Bilgi, Yasemin; Gadina, Louis; Ahumada, Juan Carlos; Moldagulov, Galymzhan; Kim, Namhun; Larsen, Eric S.; Deschamps, Maxence; Jiang, Yanqiu; Grzybowski, Bartosz A.
  作者单位：Institute for Basic Science - Korea (IBS); Ulsan National Institute of Science & Technology (UNIST)
  摘要：Despite decades of investigation, it remains unclear (and hard to predict1, 2, 3-4) how the outcomes of chemical reactions change over multidimensional 'hyperspaces' defined by reaction conditions5. Whereas human chemists can explore only a limited subset of these manifolds, automated platforms6, 7, 8, 9, 10, 11-12 can generate thousands of reactions in parallel. Yet, purification and yield quantification remain bottlenecks, constrained by time-consuming and resource-intensive analytical techn...
• The geoeconomic turn in decarbonization AI翻译
  作者：Meckling, Jonas
  作者单位：University of California System; University of California Berkeley; Harvard University
  摘要：The rise of green industrial policy is transforming efforts to decarbonize the global economy and mitigate climate change. The first three decades of climate policy centred on international cooperation on dividing up the costs of mitigation. In the new era of green industrial policy, geoeconomic competition for the benefits of decarbonization has emerged alongside international cooperation on emissions reductions. Governments invest in the manufacturing and deployment of clean technologies to ...
• Commensal yeast promotes Salmonella Typhimurium virulence AI翻译
  作者：Jaswal, Kanchan; Todd, Olivia A.; Audelo, Roberto C. Flores; Santus, William; Paul, Saikat; Duffy, Ciera M.; Eshoo III, Edward T.; Singh, Manmeet; Miao, Jian; Underhill, David M.; Peters, Brian M.; Behnsen, Judith
  作者单位：University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Tennessee System; University of Tennessee Health Science Center; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Tennessee System; University of Tennessee Health Science Center; Cedars Sinai Medical Center; Cedars Sinai Medical Center; University of Tennessee System; University of Tennessee Health Science Center
  摘要：Enteric pathogens engage in complex interactions with the host and the resident microbiota to establish gut colonization1, 2-3. Although mechanistic interactions between enteric pathogens and bacterial commensals have been extensively studied, whether and how commensal fungi affect enteric infections remain largely unknown1. Here we show that colonization with the common human gut commensal fungus Candida albicans worsened infections with the enteric pathogen Salmonella enterica subsp. enteric...
• Expanding the cytokine receptor alphabet reprograms T cells into diverse states AI翻译
  作者：Zhao, Yang; Ogishi, Masato; Pal, Aastha; Su, Leon L.; Tao, Pingdong; Jiang, Hua; Rodriguez, Grayson E.; Chen, Xiaojing; Sun, Qinli; Rysavy, Lea Wenting; Limsuwannarot, Sam; Waghray, Deepa; Kalbasi, Anusha; Garcia, K. Christopher
  作者单位：Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Stanford Cancer Institute; Howard Hughes Medical Institute; Stanford Medicine; Stanford University; Stanford University; Stanford Medicine
  摘要：T cells respond to cytokines through receptor dimers that have been selected over the course of evolution to activate canonical JAK-STAT signalling and gene expression programs1. However, the potential combinatorial diversity of JAK-STAT receptor pairings can be expanded by exploring the untapped biology of alternative non-natural pairings. Here we exploited the common gamma chain (gamma c) receptor as a shared signalling hub on T cells and enforced the expression of both natural and non-natur...
• A hypothalamic circuit that modulates feeding and parenting behaviours AI翻译
  作者：Alcantara, Ivan C.; Li, Chia; Gao, Claire; Rodriguez Gonzalez, Shakira; Mickelsen, Laura E.; Papas, Brian N.; Goldschmidt, Abigail I.; Cohen, Isabel M.; Mazzone, Christopher M.; de Araujo Salgado, Isabel; Pinol, Ramon A.; Xiao, Cuiying; Karolczak, Eva O.; Li, Jian-Liang; Cui, Guohong; Reitman, Marc L.; Krashes, Michael J.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); Brown University; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
  摘要：Across mammalian species, new mothers undergo behavioural changes to nurture their offspring and meet the caloric demands of milk production1, 2, 3, 4-5. Although many neural circuits underlying feeding and parenting behaviours are well characterized6, 7, 8-9, it is unclear how these different circuits interact and adapt during lactation. Here we performed transcriptomic profiling of the arcuate nucleus (ARC) and the medial preoptic area (MPOA) of the mouse hypothalamus in response to lactatio...
• The great university shake-up: four charts show how global higher education is changing AI翻译
  作者：Garisto, Dan
• Elementary 3D organization of active and silenced E. coli genome AI翻译
  作者：Gavrilov, Alexey A.; Shamovsky, Ilya; Zhegalova, Irina; Proshkin, Sergey; Shamovsky, Yosef; Evko, Grigory; Epshtein, Vitaly; Rasouly, Aviram; Blavatnik, Anna; Lahiri, Sudipta; Rothenberg, Eli; Razin, Sergey V.; Nudler, Evgeny
  作者单位：Russian Academy of Sciences; Institute of Gene Biology (IGB) of Russian Academy of Sciences; New York University; Russian Academy of Sciences; Engelhardt Institute of Molecular Biology, RAS; Lomonosov Moscow State University; Howard Hughes Medical Institute; NYU Langone Medical Center; Massachusetts Institute of Technology (MIT)
  摘要：Unravelling how genomes are spatially organized and how their three-dimensional (3D) architecture drives cellular functions remains a major challenge in biology1,2. In bacteria, genomic DNA is compacted into a highly ordered, condensed state called nucleoid3, 4-5. Despite progress in characterizing bacterial 3D genome architecture over recent decades6, 7-8, the fine structure and functional organization of the nucleoid remain elusive due to low-resolution contact maps from methods such as Hi-C...
• A plant-forward menu is linked to lower diabetes risk AI翻译
  作者：[Anonymous]
• Genetic suppression features ABHD18 as a Barth syndrome therapeutic target AI翻译
  作者：Masud, Sanna N.; Srivastava, Anchal; Mero, Patricia; Echezarreta, Victoria Saba; Anderson, Eve; van Buren, Lennard; Wei, Jiarun; Taylor, David Thomson; Farias, Adrian Granda; Mikolajewicz, Nicholas; Shaw, Angela; Murareanu, Brandon M.; Lohbihler, Michelle; Carney, Olivia Sniezek; van Heeringen, Simon; Clijsters, Linda; Sizova, Olga; van Ameijde, Jeroen; Nye, Freya; Habsid, Andrea; Nedyalkova, Lucy; Mcdonald, Laura; Simpson, Craig; Wybenga-Groot, Leanne; Brown, Kevin R.; Nho, Nhi; Suciu, Radu M.; Chan, Katherine; Tong, Amy H. Y.; Vaz, Frederic M.; Evers, Bastiaan; Lesurf, Robert; Papaz, Tanya; Nutter, Lauryl M. J.; Protze, Stephanie; Billmann, Maximilian; Costanzo, Michael; Andrews, Brenda J.; Myers, Chad L.; Mital, Seema; Vernon, Hilary; Brummelkamp, Thijn R.; Boone, Charles; Scott, Ian C.; Niphakis, Micah J.; Strathdee, Douglas; Nijman, Sebastian M. B.; Blomen, Vincent A.; Moffat, Jason
  作者单位：University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; University of Bonn; University of Toronto; University Health Network Toronto; Johns Hopkins University; Johns Hopkins Medicine; University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of Amsterdam; University of Amsterdam; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Labatt Family Heart Centre; University of Toronto; Hospital for Sick Children (SickKids); University of Minnesota System; University of Minnesota Twin Cities; Netherlands Cancer Institute; RIKEN
  摘要：Cardiolipin (CL) is the signature phospholipid of the inner mitochondrial membrane, where it stabilizes electron transport chain protein complexes1. The final step in CL biosynthesis relates to its remodelling: the exchange of nascent acyl chains with longer, unsaturated chains1. However, the enzyme responsible for cleaving nascent CL (nCL) has remained elusive. Here, we describe ABHD18 as a candidate deacylase in the CL biosynthesis pathway. Accordingly, ABHD18 converts CL into monolysocardio...
• Analogue speech recognition based on physical computing AI翻译
  作者：Zolfagharinejad, Mohamadreza; Buchel, Julian; Cassola, Lorenzo; Kinge, Sachin; Syed, Ghazi Sarwat; Sebastian, Abu; van der Wiel, Wilfred G.
  作者单位：University of Twente; University of Twente; University of Munster; Toyota Motor Corporation
  摘要：With the rise of decentralized computing, such as in the Internet of Things, autonomous driving and personalized healthcare, it is increasingly important to process time-dependent signals 'at the edge' efficiently: right at the place where the temporal data are collected, avoiding time-consuming, insecure and costly communication with a centralized computing facility (or 'cloud'). However, modern-day processors often cannot meet the restrained power and time budgets of edge systems because of ...