作者：Forli, Angelo; Fan, Wudi; Qi, Kevin K.; Yartsev, Michael M.
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; Howard Hughes Medical Institute; University of California Berkeley
摘要：Cognitive functions for navigation and memory rely on emergent properties of neural ensembles in the hippocampus, such as activity replay1, 2, 3, 4-5 and theta sequences6, 7, 8-9. However, whether and how these phenomena generalize across species with distinct navigational demands and neurophysiological properties remains unclear. Here we wirelessly recorded neural activity from large populations of cells and local field potentials from the hippocampus of freely flying Egyptian fruit bats (Rou...
作者：Chan, Doris S. M.; Gunter, Marc J.
作者单位：Imperial College London
作者：Heide, Janna; Bilecz, Agnes J.; Patnaik, Samarjit; Allega, Maria Francesca; Donle, Leonhard; Yang, Kaiting; Teich, Ethan; Li, Yan; Lin, Qiaoshan; Kong, Ke; Liu, Li; Yang, Tae Gyun; Cheng, Ken Chih-Chien; Shrimp, Jonathan H.; Hanson, Quinlin M.; Shen, Min; Sun, Hongmao; Shah, Hardik; Schweizer, Lisa; Zawieracz, Katarzyna; Olland, Andrea; White, Andre; Suto, Robert K.; Alhunayan, Razzaq; Tasdemir, Medine; Longman, Noa; Liang, Hua; Mann, Matthias; Stott, Gordon M.; Hall, Matthew D.; Schworer, Simon; Weichselbaum, Ralph R.; Piffko, Andras; Lengyel, Ernst
作者单位：University of Chicago; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS); University of Chicago; University of Chicago; University of Chicago; University of Chicago; Robert H. Lurie Comprehensive Cancer Center; Max Planck Society; University of Chicago; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; University of Chicago
摘要：Cancer-associated fibroblasts (CAFs) have a pivotal cancer-supportive role, yet CAF-targeted therapies are lacking1,2. Here, using spatial transcriptomics and single-cell RNA sequencing, we investigate the role of nicotinamide N-methyltransferase (NNMT) in high-grade serous ovarian cancer. Mechanistically, NNMT-induced H3K27me3 hypomethylation drives complement secretion from CAFs, attracting immunosuppressive myeloid-derived suppressor cells (MDSCs) to the tumour. Nnmt knockout in immunocompe...
作者：Zhang, Ya-Qin; Jagannathan, Ramesh; Pires de Carvalho, Denise; Dougan, Lorna; Ganesh Pichamuthu, Bala; Ndlovu, Sibonokuhle
作者单位：Tsinghua University; Tsinghua University; New York University; New York University Abu Dhabi; New York University; New York University Abu Dhabi; Universidade Federal Rural do Rio de Janeiro (UFRRJ); Universidade Federal do Rio de Janeiro; University of Leeds; SRM Institute of Science & Technology Chennai; University of Johannesburg
作者：Kersting, Diego K.; Ramos-Espla, Alfonso A.; Templado, Jose; Sala, Enric
作者单位：Universitat d'Alacant
