8082期

最新文章

• Determinants of successful AAV-vectored delivery of HIV-1 bNAbs in early life AI翻译
  作者：Ardeshir, Amir; O'Hagan, Daniel; Mehta, Isha; Shandilya, Siddhartha; Hopkins, Lincoln L. J.; Adamson, Lourdes; Kuroda, Marcelo J.; Hahn, Patricia A.; da Costa, Lucas A. B.; Fuchs, Sebastian P.; Martinez-Navio, Jose M.; Gardner, Matthew R.; Van Rompay, Koen K. A.; Magnani, Diogo M.; Lifson, Jeffrey D.; Gao, Guangping; Farzan, Michael; Desrosiers, Ronald C.; Das, Jishnu; Martins, Mauricio A.
  作者单位：University of California System; University of California Davis; State University System of Florida; University of Florida; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Miami; Emory University; Emory University; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; Tulane University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital
  摘要：Despite advances in HIV-1 prophylaxis, vertical transmission remains a pressing problem in developing countries1. Given the promise of broadly neutralizing antibodies (bNAbs) for HIV-1 prevention2, we hypothesized that neonatal delivery of bNAbs using adeno-associated virus (AAV) could provide durable HIV-1 immunity during infancy. Here, using infant rhesus macaques (Macaca mulatta) as a model, we show that a one-time administration of an AAV vector encoding bNAb 3BNC117 at birth led to sustai...
• Author Correction: A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome (Mar, 10.1038/s41586-025-08723-7 , 2025) AI翻译
  作者：Jangra, Manoj; Travin, Dmitrii Y.; Aleksandrova, Elena V.; Kaur, Manpreet; Darwish, Lena; Koteva, Kalinka; Klepacki, Dorota; Wang, Wenliang; Tiffany, Maya; Sokaribo, Akosiererem; Chen, Xuefei; Deng, Zixin; Tao, Meifeng; Coombes, Brian K.; Vazquez-Laslop, Nora; Polikanov, Yury S.; Mankin, Alexander S.; Wright, Gerard D.
• How the pelvis evolved to enable human bipedalism AI翻译
  作者：Berthelot, Camille
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Institut Pasteur Paris; Pasteur Network; Institut Pasteur Paris
• Structural basis of fast N-type inactivation in Kv channels AI翻译
  作者：Tan, Xiao-Feng; Fernandez-Marino, Ana I.; Li, Yan; Chang, Tsg-Hui; Swartz, Kenton J.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); University of Colorado System; University of Colorado Anschutz; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
  摘要：Action potentials are generated by opening of voltage-activated sodium (Nav) and potassium (Kv) channels1, which can rapidly inactivate to shape the nerve impulse and contribute to synaptic facilitation and short-term memory1, 2, 3-4. The mechanism of fast inactivation was proposed to involve an intracellular domain that blocks the internal pore in both Nav5,6 and Kv7, 8-9 channels; however, recent studies in Nav10,11 and Kv12,13 channels support a mechanism in which the internal pore closes d...
• How universities came to be - and why they are in trouble now AI翻译
  作者：Altbach, Philip G.
  作者单位：Boston College
• LIGO is 10 years old: black-hole breakthroughs will 'only get better' AI翻译
  作者：Castelvecchi, Davide
• Combat the human-made causes of Spain's wildfires AI翻译
  作者：Miguel Aviles, Jesus
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Experimental de Zonas Aridas (EEZA)
• Mysterious changes near Earth's core revealed by satellites in space AI翻译
  作者：Witze, Alexandra
• Observing differential spin currents by resonant inelastic X-ray scattering AI翻译
  作者：Gu, Yanhong; Barker, Joseph; Li, Jiemin; Kikkawa, Takashi; Camino, Fernando; Kisslinger, Kim; Sinsheimer, John; Lienhard, Lukas; Bauer, Jackson J.; Ross, Caroline A.; Basov, Dmitri N.; Saitoh, Eiji; Pelliciari, Jonathan; Bauer, Gerrit E. W.; Bisogni, Valentina
  作者单位：United States Department of Energy (DOE); Brookhaven National Laboratory; University of Leeds; University of Leeds; Tohoku University; Japan Atomic Energy Agency; United States Department of Energy (DOE); Brookhaven National Laboratory; Massachusetts Institute of Technology (MIT); Columbia University; University of Tokyo; University of Tokyo; Tohoku University; RIKEN
  摘要：Controlling spin currents, that is, the flow of spin angular momentum, in small magnetic devices, is the principal objective of spin electronics, a main contender for future energy-efficient information technologies1,2. A pure spin current has never been measured directly because the associated electric stray fields and/or shifts in the non-equilibrium spin-dependent distribution functions are too small for conventional experimental detection methods optimized for charge transport3,4. Here we ...
• Reforming Africa's food systems will have global benefits AI翻译
  作者：Barrett, Christopher B.; Herrero, Mario; Djikeng, Appolinaire; Fanzo, Jessica
  作者单位：Cornell University; CGIAR; International Livestock Research Institute (ILRI); Columbia University