2025

最新文章

• Close the biodiversity funding gap by teaching conservation to financial professionals AI翻译
  作者：Li, Xiao
  作者单位：Xi'an Jiaotong University
• Record-setting trove of buried beads speaks to power of ancient women AI翻译
  作者：[Anonymous]
• Signs of damage that drive protein degradation AI翻译
  作者：Freeberg, Alfred; Rape, Michael
  作者单位：University of California System; University of California Berkeley; Howard Hughes Medical Institute; University of California System; University of California Berkeley; University of California System; University of California Berkeley
• C-terminal amides mark proteins for degradation via SCF-FBXO31 AI翻译
  作者：Muhar, Matthias F.; Farnung, Jakob; Cernakova, Martina; Hofmann, Raphael; Henneberg, Lukas T.; Pfleiderer, Moritz M.; Denoth-Lippuner, Annina; Kalcic, Filip; Nievergelt, Ajse S.; Peters Al-Bayati, Marwa; Sidiropoulos, Nikolaos D.; Beier, Viola; Mann, Matthias; Jessberger, Sebastian; Jinek, Martin; Schulman, Brenda A.; Bode, Jeffrey W.; Corn, Jacob E.
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Max Planck Society; University of Zurich; University of Zurich; Max Planck Society
  摘要：During normal cellular homeostasis, unfolded and mislocalized proteins are recognized and removed, preventing the build-up of toxic byproducts1. When protein homeostasis is perturbed during ageing, neurodegeneration or cellular stress, proteins can accumulate several forms of chemical damage through reactive metabolites2,3. Such modifications have been proposed to trigger the selective removal of chemically marked proteins3, 4, 5-6; however, identifying modifications that are sufficient to ind...
• Regional and institutional trends in assessment for academic promotion AI翻译
  作者：Lim, B. H.; D'Ippoliti, C.; Dominik, M.; Hernandez-Mondragon, A. C.; Vermeir, K.; Chong, K. K.; Hussein, H.; Morales-Salgado, V. S.; Cloete, K. J.; Kimengsi, J. N.; Balboa, L.; Mondello, S.; dela Cruz, T. E.; Lopez-Verges, S.; Sidi Zakari, I.; Simonyan, A.; Palomo, I.; Rezek Jambrak, A.; Germo Nzweundji, J.; Molnar, A.; Saktiawati, A. M. I.; Elagroudy, S.; Kumar, P.; Enany, S.; Narita, V.; Backes, M.; Siciliano, V.; Egamberdieva, D.; Flores Bueso, Y.
  作者单位：Universiti Tunku Abdul Rahman (UTAR); Sapienza University Rome; University of St Andrews; CINVESTAV - Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional; Instituto Politecnico Nacional - Mexico; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Humanities & Social Sciences (INSHS); Universite Paris Cite; University of Oxford; University of South Africa; National Research Foundation - South Africa; iThemba LABS; Technische Universitat Dresden; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Buenos Aires National Academy of Medicine; IMEX - Instituto de Medicina Experimental; University of Messina; University of Santo Tomas; Instituto Conmemorativo Gorgas de Estudios de la Salud; Secretaria Nacional de Ciencia, Tecnologia e Innovacin (SENACYT); Abdou Moumouni University; University of Sussex; Institut de Recherche pour le Developpement (IRD); Communaute Universite Grenoble Alpes; Institut National Polytechnique de Grenoble; INRAE; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); University of Zagreb; Swinburne University of Technology; Technical University of Munich; Gadjah Mada University; Egyptian Knowledge Bank (EKB); Ain Shams University; University of Witwatersrand; Egyptian Knowledge Bank (EKB); Suez Canal University; University of Namibia; North West University - South Africa; Istituto Italiano di Tecnologia - IIT; Tashkent Institute of Irrigation & Agricultural Mechanization Engineers; National University of Uzbekistan; University College Cork; University of Washington; University of Washington Seattle
  摘要：The assessment of research performance is widely seen as a vital tool in upholding the highest standards of quality, with selection and competition believed to drive progress. Academic institutions need to take critical decisions on hiring and promotion, while facing external pressure by also being subject to research assessment1, 2, 3-4. Here we present an outlook on research assessment for career progression with specific focus on promotion to full professorship, based on 314 policies from 1...
• Gliomagenesis mimics an injury response orchestrated by neural crest-like cells AI翻译
  作者：Hamed, Akram A.; Hua, Kui; Trinh, Quang M.; Simons, Benjamin D.; Marioni, John C.; Stein, Lincoln D.; Dirks, Peter B.
  作者单位：University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Hospital for Sick Children (SickKids); CRUK Cambridge Institute; Cancer Research UK; University of Cambridge; Ontario Institute for Cancer Research; University of Toronto; European Molecular Biology Laboratory (EMBL); European Bioinformatics Institute; Wellcome Trust Sanger Institute; University of Cambridge; University of Cambridge; University of Toronto
  摘要：Glioblastoma is an incurable brain malignancy. By the time of clinical diagnosis, these tumours exhibit a degree of genetic and cellular heterogeneity that provides few clues to the mechanisms that initiate and drive gliomagenesis1,2. Here, to explore the early steps in gliomagenesis, we utilized conditional gene deletion and lineage tracing in tumour mouse models, coupled with serial magnetic resonance imaging, to initiate and then closely track tumour formation. We isolated labelled and unla...
• The science behind the first pig-organ transplant trial in humans AI翻译
  作者：Mallapaty, Smriti; Kozlov, Max
• Transforming US agriculture for carbon removal with enhanced weathering AI翻译
  作者：Beerling, David J.; Kantzas, Euripides P.; Lomas, Mark R.; Taylor, Lyla L.; Zhang, Shuang; Kanzaki, Yoshiki; Eufrasio, Rafael M.; Renforth, Phil; Mecure, Jean-Francois; Pollitt, Hector; Holden, Philip B.; Edwards, Neil R.; Koh, Lenny; Epihov, Dimitar Z.; Wolf, Adam; Hansen, James E.; Banwart, Steven A.; Pidgeon, Nick F.; Reinhard, Christopher T.; Planavsky, Noah J.; Val Martin, Maria
  作者单位：University of Sheffield; Texas A&M University System; Texas A&M University College Station; University System of Georgia; Georgia Institute of Technology; University of Sheffield; Heriot Watt University; University of Exeter; University of Cambridge; The World Bank; Open University - UK; Princeton University; Columbia University; University of Leeds; Cardiff University; Yale University
  摘要：Enhanced weathering (EW) with agriculture uses crushed silicate rocks to drive carbon dioxide removal (CDR)1,2. If widely adopted on farmlands, it could help achieve net-zero emissions by 20502, 3-4. Here we show, with a detailed US state-specific carbon cycle analysis constrained by resource provision, that EW deployed on agricultural land could sequester 0.16-0.30 GtCO2 yr-1 by 2050, rising to 0.25-0.49 GtCO2 yr-1 by 2070. Geochemical assessment of rivers and oceans suggests effective transp...
• Viral tolerance enabled by a bat-specific genomic tweak AI翻译
  作者：Zhu, Junji; Gack, Michaela U.
  作者单位：Cleveland Clinic Foundation
• Geological Net Zero and the need for disaggregated accounting for carbon sinks AI翻译
  作者：Allen, Myles R.; Frame, David J.; Friedlingstein, Pierre; Gillett, Nathan P.; Grassi, Giacomo; Gregory, Jonathan M.; Hare, William; House, Jo; Huntingford, Chris; Jenkins, Stuart; Jones, Chris D.; Knutti, Reto; Lowe, Jason A.; Matthews, H. Damon; Meinshausen, Malte; Meinshausen, Nicolai; Peters, Glen P.; Plattner, Gian-Kasper; Raper, Sarah; Rogelj, Joeri; Stott, Peter A.; Solomon, Susan; Stocker, Thomas F.; Weaver, Andrew J.; Zickfeld, Kirsten
  作者单位：University of Oxford; University of Oxford; University of Canterbury; University of Exeter; European Commission Joint Research Centre; EC JRC ISPRA Site; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC National Centre for Atmospheric Science; University of Reading; Met Office - UK; University of Bristol; UK Centre for Ecology & Hydrology (UKCEH); Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Leeds; Concordia University - Canada; University of Melbourne; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Manchester Metropolitan University; Imperial College London; University of Exeter; Massachusetts Institute of Technology (MIT); University of Bern; University of Victoria; Simon Fraser University
  摘要：Achieving net-zero global emissions of carbon dioxide (CO2), with declining emissions of other greenhouse gases, is widely expected to halt global warming. CO2 emissions will continue to drive warming until fully balanced by active anthropogenic CO2 removals. For practical reasons, however, many greenhouse gas accounting systems allow some 'passive' CO2 uptake, such as enhanced vegetation growth owing to CO2 fertilization, to be included as removals in the definition of net anthropogenic emiss...