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作者：Zhou, Jia; Noviello, Colleen M.; Teng, Jinfeng; Moore, Haley; Lega, Bradley; Hibbs, Ryan E.
作者单位：University of California System; University of California San Diego; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of California System; University of California San Diego
摘要：Type A GABA (gamma-aminobutyric acid) receptors (GABAA receptors) mediate most fast inhibitory signalling in the brain and are targets for drugs that treat epilepsy, anxiety, depression and insomnia and for anaesthetics1,2. These receptors comprise a complex array of 19 related subunits, which form pentameric ligand-gated ion channels. The composition and structure of native GABAA receptors in the human brain have been inferred from subunit localization in tissue1,3, functional measurements an...
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作者：Yeo, Youngki; Sharaby, Yoav; Roy, Nirmal; Raab, Noam; Watanabe, Kenji; Taniguchi, Takashi; Ben Shalom, Moshe
作者单位：Tel Aviv University; National Institute for Materials Science; National Institute for Materials Science
摘要：Expanding the performance of field-effect devices is a key challenge of the ever-growing chip industry at the core of current technologies1. Non-volatile multiferroic transistors that control atomic movements rather than purely electronic distribution are highly desired2. Recently, a field-effect control over structural transitions was achieved in commensurate stacking configurations of honeycomb van der Waals (vdW) polytypes by sliding boundary strips between oppositely polarized domains3, 4,...
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作者：Wong, Kwok-Kin; Maser, Richard S.; Bachoo, Robert M.; Menon, Jayant; Carrasco, Daniel R.; Gu, Yansong; Alt, Frederick W.; Depinho, Ronald A.
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作者：Ramirez-Bravo, Osvaldo Eric
作者单位：Benemerita Universidad Autonoma de Puebla
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作者：Dolgin, Elie
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作者：Chen, Chen; Xiao, Wenya; Chen, Han Y. H.
作者单位：Lakehead University; Chinese Academy of Sciences; Institute of Botany, CAS; Jiangsu University; University of Michigan System; University of Michigan
摘要：Positive effects of plant diversity on productivity have been globally demonstrated and explained by two main effects: complementarity effects and selection effects1, 2, 3-4. However, plant diversity experiments have shown substantial variation in these effects, with driving factors poorly understood4, 5-6. On the basis of a meta-analysis of 452 experiments across the globe, we show that productivity increases on average by 15.2% from monocultures to species mixtures with an average species ri...
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作者：Huang, Huaizhi; Hu, Chunling; Na, Jie; Hart, Steven N.; Gnanaolivu, Rohan David; Abozaid, Mohamed; Rao, Tara; Tecleab, Yohannes A.; CARRIERS Consortium, Christine B.; Pesaran, Tina; Lyra, Paulo Cilas Morais; Karam, Rachid; Yadav, Siddhartha; Nathanson, Katherine L.; Domchek, Susan M.; de la Hoya, Miguel; Robson, Mark; Mehine, Miika; Bandlamudi, Chaitanya; Mandelker, Diana; Monteiro, Alvaro N. A.; Iversen, Edwin S.; Boddicker, Nicholas; Chen, Wenan; Richardson, Marcy E.; Couch, Fergus J.
作者单位：Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; H Lee Moffitt Cancer Center & Research Institute; Mayo Clinic; University of Pennsylvania; Hospital Clinico San Carlos; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Duke University
摘要：Germline BRCA2 loss-of function variants, which can be identified through clinical genetic testing, predispose to several cancers1, 2, 3, 4-5. However, variants of uncertain significance limit the clinical utility of test results. Thus, there is a need for functional characterization and clinical classification of all BRCA2 variants to facilitate the clinical management of individuals with these variants. Here we analysed all possible single-nucleotide variants from exons 15 to 26 that encode ...
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作者：Wheeler, Michael A.; Quintana, Francisco J.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：The nervous and immune systems have complementary roles in the adaptation of organisms to environmental changes. However, the mechanisms that mediate cross-talk between the nervous and immune systems, called neuroimmune interactions, are poorly understood. In this Review, we summarize advances in the understanding of neuroimmune communication, with a principal focus on the central nervous system (CNS): its response to immune signals and the immunological consequences of CNS activity. We highli...
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作者：[Anonymous]
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作者：Wang, Bo; Che, Zhiyuan; Cheng, Cheng; Tong, Caili; Shi, Lei; Shen, Yijie; Bliokh, Konstantin Y.; Zi, Jian
作者单位：Fudan University; Henan University; Henan Academy of Sciences; Fudan University; Nanyang Technological University; Nanyang Technological University; Hiroshima University; RIKEN
摘要：Topological wave structures, such as vortices1, 2, 3, 4, 5-6, polarization textures7, 8, 9, 10-11 and skyrmions12, 13, 14, 15, 16, 17, 18-19, appear in various quantum and classical wave fields, including optics and acoustics. In particular, optical vortices have found numerous applications20,21, ranging from quantum information to astrophysics. Furthermore, both optical and acoustic structured waves are crucial in the manipulation of small particles22, 23, 24-25, from atoms to macroscopic bio...
