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作者：Witze, Alexandra
摘要：Earthquakes ringing through the planet illuminate how its heart is transforming.
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作者：Fane, Mitchell E.; Chhabra, Yash; Alicea, Gretchen M.; Maranto, Devon A.; Douglass, Stephen M.; Webster, Marie R.; Rebecca, Vito W.; Marino, Gloria E.; Almeida, Filipe; Ecker, Brett L.; Zabransky, Daniel J.; Huser, Laura; Beer, Thomas; Tang, Hsin-Yao; Kossenkov, Andrew; Herlyn, Meenhard; Speicher, David W.; Xu, Wei; Xu, Xiaowei; Jaffee, Elizabeth M.; Aguirre-Ghiso, Julio A.; Weeraratna, Ashani T.
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作者：Spencer Chapman, Michael; Mitchell, Emily; Yoshida, Kenichi; Williams, Nicholas; Fabre, Margarete A.; Ranzoni, Anna Maria; Robinson, Philip S.; Kregar, Lori D.; Wilk, Matthias; Boettcher, Steffen; Mahbubani, Krishnaa; Saeb Parsy, Kourosh; Gowers, Kate H. C.; Janes, Sam M.; Ng, Stanley W. K.; Hoare, Matt; Green, Anthony R.; Vassiliou, George S.; Cvejic, Ana; Manz, Markus G.; Laurenti, Elisa; Martincorena, Inigo; Stratton, Michael R.; Nangalia, Jyoti; Coorens, Tim H. H.; Campbell, Peter J.
作者单位：Wellcome Trust Sanger Institute; University of London; Queen Mary University London; University of Cambridge; University of Cambridge; AstraZeneca; University of Zurich; University of Zurich; University Zurich Hospital; University of Cambridge; University of Cambridge; University of London; University College London; University of Cambridge; University of Copenhagen; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：DNA is subject to continual damage, leaving each cell with thousands of individual DNA lesions at any given moment1, 2-3. The efficiency of DNA repair means that most known classes of lesion have a half-life of minutes to hours3,4, but the extent to which DNA damage can persist for longer durations remains unknown. Here, using high-resolution phylogenetic trees from 89 donors, we identified mutations arising from 818 DNA lesions that persisted across multiple cell cycles in normal human stem c...
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作者：Van Noorden, Richard
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作者：Shaw, Robyn E.; Farquharson, Katherine A.; Bruford, Michael W.; Coates, David J.; Elliott, Carole P.; Mergeay, Joachim; Ottewell, Kym M.; Segelbacher, Gernot; Hoban, Sean; Hvilsom, Christina; Perez-Espona, Silvia; Runis, Dainis; Aravanopoulos, Filippos; Bertola, Laura D.; Cotrim, Helena; Cox, Karen; Cubric-Curik, Vlatka; Ekblom, Robert; Godoy, Jose A.; Konopinski, Maciej K.; Laikre, Linda; Russo, Isa-Rita M.; Velickovic, Nevena; Vergeer, Philippine; Vila, Carles; Brajkovic, Vladimir; Field, David L.; Goodall-Copestake, William P.; Hailer, Frank; Hopley, Tara; Zachos, Frank E.; Alves, Paulo C.; Biedrzycka, Aleksandra; Binks, Rachel M.; Buiteveld, Joukje; Buzan, Elena; Byrne, Margaret; Huntley, Barton; Iacolina, Laura; Keehnen, Naomi L. P.; Klinga, Peter; Kopatz, Alexander; Kurland, Sara; Leonard, Jennifer A.; Manfrin, Chiara; Marchesini, Alexis; Millar, Melissa A.; Orozco-terWengel, Pablo; Ottenburghs, Jente; Posledovich, Diana; Spencer, Peter B.; Tourvas, Nikolaos; Unuk Nahberger, Tina; van Hooft, Pim; Verbylaite, Rita; Vernesi, Cristiano; Grueber, Catherine E.
作者单位：Murdoch University; Australian National University; University of Canberra; University of Sydney; University of Sydney; Cardiff University; University of Western Australia; Research Institute for Nature & Forest; KU Leuven; University of Freiburg; University of Edinburgh; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Roslin Institute; University of Edinburgh; Latvian State Forest Research Institute Silava; Aristotle University of Thessaloniki; University of Copenhagen; Universidade de Lisboa; University of Zagreb; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Biologica de Donana (EBD); Polish Academy of Sciences; Stockholm University; University of Novi Sad; Wageningen University & Research; Macquarie University; Edith Cowan University; Chinese Academy of Sciences; Institute of Zoology, CAS; University of Vienna; University of the Free State; Charles Darwin University; Universidade do Porto; Universidade do Porto; Wageningen University & Research; University of Primorska; University of Sassari; Aalborg University; Swedish University of Agricultural Sciences; Technical University Zvolen; Czech University of Life Sciences Prague; Norwegian Institute Nature Research; Uppsala University; University of Trieste; Consiglio Nazionale delle Ricerche (CNR); Istituto di Ricerca sugli Ecosistemi Terrestri (IRET); National Biodiversity Future Center; Wageningen University & Research; Wageningen University & Research; Slovenian Forestry Institute; Fondazione Edmund Mach
摘要：Mitigating loss of genetic diversity is a major global biodiversity challenge1, 2, 3-4. To meet recent international commitments to maintain genetic diversity within species5,6, we need to understand relationships between threats, conservation management and genetic diversity change. Here we conduct a global analysis of genetic diversity change via meta-analysis of all available temporal measures of genetic diversity from more than three decades of research. We show that within-population gene...
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作者：Vilgalys, Tauras P.; Klunk, Jennifer; Demeure, Christian E.; Cheng, Xiaoheng; Shiratori, Mari; Madej, Julien; Beau, Remi; Elli, Derek; Patino, Maria I.; Redfern, Rebecca; Dewitte, Sharon N.; Gamble, Julia A.; Boldsen, Jesper L.; Carmichael, Ann; Varlik, Nukhet; Eaton, Katherine; Grenier, Jean-Christophe; Golding, G. Brian; Devault, Alison; Rouillard, Jean-Marie; Yotova, Vania; Sindeaux, Renata; Ye, Chun Jimmie; Bikaran, Matin; Dumaine, Anne; Brinkworth, Jessica F.; Missiakas, Dominique; Rouleau, Guy A.; Steinrucken, Matthias; Pizarro-Cerda, Javier; Poinar, Hendrik N.; Barreiro, Luis B.
作者单位：University of Chicago; McMaster University; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; University of Chicago; University of Chicago; University of South Carolina System; University of South Carolina Columbia; University of Manitoba; University of Southern Denmark; Indiana University System; Indiana University Bloomington; Rutgers University System; Rutgers University Newark; Rutgers University New Brunswick; Universite de Montreal; University of Michigan System; University of Michigan; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; McGill University; University of Chicago; McMaster University; Canadian Institute for Advanced Research (CIFAR); University of Chicago; University of Chicago
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作者：Stephen-Victor, Emmanuel; Kuziel, Gavin A.; Martinez-Blanco, Monica; Jugder, Bat-Erdene; Benamar, Mehdi; Wang, Ziwei; Chen, Qian; Lozano, Gabriel L.; Abdel-Gadir, Azza; Cui, Ye; Fong, Jason; Saint-Denis, Elisa; Chang, Iris; Nadeau, Kari C.; Phipatanakul, Wanda; Zhang, Angela; Farraj, Farida Abi; Holder-Niles, Faye; Zeve, Daniel; Breault, David T.; Schmitz-Abe, Klaus; Rachid, Rima; Crestani, Elena; Rakoff-Nahoum, Seth; Chatila, Talal A.
作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; AstraZeneca; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Stanford University; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; University of Miami; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：Tolerance to dietary antigens is critical for avoiding deleterious type 2 immune responses resulting in food allergy (FA) and anaphylaxis1,2. However, the mechanisms resulting in both the maintenance and failure of tolerance to food antigens are poorly understood. Here we demonstrate that the goblet-cell-derived resistin-like molecule beta (RELM beta)3,4 is a critical regulator of oral tolerance. RELM beta is abundant in the sera of both patients with FA and mouse models of FA. Deletion of REL...
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作者：Lacks, Daniel J.; Sow, Mamadou
作者单位：University System of Ohio; Case Western Reserve University
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作者：Liu, Yongsheng
作者单位：Henan Institute of Science & Technology
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作者：[Anonymous]
