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作者：Gao, Zirui; Li, Aowen; Liu, Xingwu; Peng, Mi; Yu, Shixiang; Wang, Maolin; Ge, Yuzhen; Li, Chengyu; Wang, Tie; Wang, Zhaohua; Zhou, Wu; Ma, Ding
作者单位：Peking University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：The use of reactive supports to disperse metal species is crucial for constructing highly efficient interfacial catalysts, by tuning the competitive reactant adsorption-activation pattern in supported metal catalysts into a non-competitive mechanism1, 2-3. However, these reactive supports are prone to deterioration during catalysis, limiting the lifespan of the catalyst and their potential practical applications4. New strategies are needed to simultaneously protect reactive supports and surfac...
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作者：Huang, Buwei; Abedi, Mohamad; Ahn, Green; Coventry, Brian; Sappington, Isaac; Tang, Cong; Wang, Rong; Schlichthaerle, Thomas; Zhang, Jason Z.; Wang, Yujia; Goreshnik, Inna; Chiu, Ching Wen; Chazin-Gray, Adam; Chan, Sidney; Gerben, Stacey; Murray, Analisa; Wang, Shunzhi; O'Neill, Jason; Yi, Li; Yeh, Ronald; Misquith, Ayesha; Wolf, Anitra; Tomasovic, Luke M.; Piraner, Dan I.; Duran Gonzalez, Maria J.; Bennett, Nathaniel R.; Venkatesh, Preetham; Ahlrichs, Maggie; Dobbins, Craig; Yang, Wei; Wang, Xinru; Sahtoe, Danny D.; Vafeados, Dionne; Mout, Rubul; Shivaei, Shirin; Cao, Longxing; Carter, Lauren; Stewart, Lance; Spangler, Jamie B.; Roybal, Kole T.; Greisen, Per, Jr.; Li, Xiaochun; Bernardes, Goncalo J. L.; Bertozzi, Carolyn R.; Baker, David
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Stanford University; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; Universidade de Lisboa; University of Texas System; University of Texas Southwestern Medical Center; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; University of California System; University of California San Francisco; Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW); Harvard University; Harvard Medical School; California Institute of Technology; Westlake University; University of Cambridge; Howard Hughes Medical Institute; Stanford University
摘要：Endocytosis and lysosomal trafficking of cell surface receptors can be triggered by endogenous ligands. Therapeutic approaches such as lysosome-targeting chimaeras1,2 (LYTACs) and cytokine receptor-targeting chimeras3 (KineTACs) have used this to target specific proteins for degradation by fusing modified native ligands to target binding proteins. Although powerful, these approaches can be limited by competition with native ligands and requirements for chemical modification that limit genetic ...
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作者：Houlahan, Kathleen E.; Mangiante, Lise; Sotomayor-Vivas, Cristina; Adimoelja, Alvina; Park, Seongyeol; Khan, Aziz; Pribus, Sophia J.; Ma, Zhicheng; Caswell-Jin, Jennifer L.; Curtis, Christina
作者单位：Stanford University; Stanford Cancer Institute; Stanford University; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI)
摘要：Breast cancer is a highly heterogeneous disease whose prognosis and treatment as defined by the expression of three receptors-oestrogen receptor (ER), progesterone receptor and human epidermal growth factor receptor 2 (HER2; encoded by ERBB2)-is insufficient to capture the full spectrum of clinical outcomes and therapeutic vulnerabilities. Previously, we demonstrated that transcriptional and genomic profiles define eleven integrative subtypes with distinct clinical outcomes, including four ER+...
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作者：Sahu, Sounak; Galloux, Melissa; Southon, Eileen; Caylor, Dylan; Sullivan, Teresa; Arnaudi, Matteo; Zanti, Maria; Geh, Josephine; Chari, Raj; Michailidou, Kyriaki; Papaleo, Elena; Sharan, Shyam K.
作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Technical University of Denmark; Cyprus Institute of Neurology & Genetics; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research
摘要：Sequencing-based genetic tests have uncovered a vast array of BRCA2 sequence variants1. Owing to limited clinical, familial and epidemiological data, thousands of variants are considered to be variants of uncertain significance2, 3-4 (VUS). Here we have utilized CRISPR-Cas9-based saturation genome editing in a humanized mouse embryonic stem cell line to determine the functional effect of VUS. We have categorized nearly all possible single nucleotide variants (SNVs) in the region that encodes t...
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作者：Main, D.; Drmota, P.; Nadlinger, D. P.; Ainley, E. M.; Agrawal, A.; Nichol, B. C.; Srinivas, R.; Araneda, G.; Lucas, D. M.
作者单位：University of Oxford
摘要：Distributed quantum computing (DQC) combines the computing power of multiple networked quantum processing modules, ideally enabling the execution of large quantum circuits without compromising performance or qubit connectivity1,2. Photonic networks are well suited as a versatile and reconfigurable interconnect layer for DQC; remote entanglement shared between matter qubits across the network enables all-to-all logical connectivity through quantum gate teleportation (QGT)3,4. For a scalable DQC...
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作者：Morales, Ariadna E.; Dong, Yue; Brown, Thomas; Baid, Kaushal; Kontopoulos, Dimitrios-Georgios; Gonzalez, Victoria; Huang, Zixia; Ahmed, Alexis-Walid; Bhuinya, Arkadeb; Hilgers, Leon; Winkler, Sylke; Hughes, Graham; Li, Xiaomeng; Lu, Ping; Yang, Yixin; Kirilenko, Bogdan M.; Devanna, Paolo; Lama, Tanya M.; Nissan, Yomiran; Pippel, Martin; Davalos, Liliana M.; Vernes, Sonja C.; Puechmaille, Sebastien J.; Rossiter, Stephen J.; Yovel, Yossi; Prescott, Joseph B.; Kurth, Andreas; Ray, David A.; Lim, Burton K.; Myers, Eugene; Teeling, Emma C.; Banerjee, Arinjay; Irving, Aaron T.; Hiller, Michael
作者单位：Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Goethe University Frankfurt; University of Edinburgh; Zhejiang University; Max Planck Society; Helmholtz Association; Helmholtz-Zentrum Dresden-Rossendorf (HZDR); University of Saskatchewan; University of Saskatchewan; University College Dublin; Max Planck Society; State University of New York (SUNY) System; Stony Brook University; Tel Aviv University; Tel Aviv University; State University of New York (SUNY) System; Stony Brook University; University of St Andrews; Institut Universitaire de France; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; University of London; Queen Mary University London; Robert Koch Institute; Texas Tech University System; Texas Tech University; Royal Ontario Museum; University of Waterloo; University of Toronto; University of British Columbia; Zhejiang University; Zhejiang University; University of Edinburgh; Smith College
摘要：Zoonoses are infectious diseases transmitted from animals to humans. Bats have been suggested to harbour more zoonotic viruses than any other mammalian order1. Infections in bats are largely asymptomatic2,3, indicating limited tissue-damaging inflammation and immunopathology. To investigate the genomic basis of disease resistance, the Bat1K project generated reference-quality genomes of ten bat species, including potential viral reservoirs. Here we describe a systematic analysis covering 115 m...
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作者：Kaur, Navjot; Kovner, Rothem; Gulden, Forrest O.; Pletikos, Mihovil; Andrijevic, David; Zhu, Tianjia; Silbereis, John; Shibata, Mikihito; Shibata, Akemi; Liu, Yuting; Ma, Shaojie; Salla, Nikkita; de Martin, Xabier; Klaric, Thomas S.; Burke, Megan; Franjic, Daniel; Cho, Hyesun; Yuen, Matthew; Chatterjee, Ipsita; Soric, Paula; Esakkimuthu, Devippriya; Moser, Markus; Santpere, Gabriel; Mineur, Yann S.; Pattabiraman, Kartik; Picciotto, Marina R.; Huang, Hao; Sestan, Nenad
作者单位：Yale University; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Yale University; Hospital del Mar Research Institute; Hospital del Mar; Pompeu Fabra University; Barcelona Biomedical Research Park; Technical University of Munich; Yale University; Yale University; University of Pennsylvania; Yale University; Yale University; Yale University; Yale University
摘要：The ventrolateral pallial (VLp) excitatory neurons in the claustro-amygdalar complex and piriform cortex (PIR; which forms part of the palaeocortex) form reciprocal connections with the prefrontal cortex (PFC), integrating cognitive and sensory information that results in adaptive behaviours1, 2, 3, 4-5. Early-life disruptions in these circuits are linked to neuropsychiatric disorders4, 5, 6, 7-8, highlighting the importance of understanding their development. Here we reveal that the transcrip...
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作者：[Anonymous]
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作者：Maida, Yoshiko; Yasukawa, Mami; Furuuchi, Miho; Lassmann, Timo; Possemato, Richard; Okamoto, Naoko; Kasim, Vivi; Hayashizaki, Yoshihide; Hahn, William C.; Masutomi, Kenkichi
作者单位：National Cancer Center - Japan; RIKEN; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Japan Science & Technology Agency (JST)
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作者：Smit, Daniel J.; Pantel, Klaus
作者单位：University of Hamburg; University Medical Center Hamburg-Eppendorf
