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作者：Zhang, Dingpeng; Duque-Jimenez, Jhoely; Facchinetti, Francesco; Brixi, Garyk; Rhee, Kaitlin; Feng, William W.; Janne, Pasi A.; Zhou, Xin
作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
摘要：Cancer cells require high levels of iron for rapid proliferation, leading to significant upregulation of cell-surface transferrin receptor 1 (TfR1), which mediates iron uptake by binding to the iron-carrying protein transferrin1-3. Leveraging this phenomenon and the fast endocytosis rate of TfR1 (refs. 4,5), we developed transferrin receptor targeting chimeras (TransTACs), a heterobispecific antibody modality for membrane protein degradation. TransTACs are engineered to drive rapid co-internal...
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作者：Avila, Jesus; Mayor Jr, Federico; Bovolenta, Paola
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作者：Fradet-Turcotte, Amelie; Canny, Marella D.; Escribano-Diaz, Cristina; Orthwein, Alexandre; Leung, Charles C. Y.; Huang, Hao; Landry, Marie-Claude; Kitevski-LeBlanc, Julianne; Noordermeer, Sylvie M.; Sicheri, Frank; Durocher, Daniel
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作者：Davidson, W. Sean
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作者：Reimund, Mart; Dearborn, Altaira D.; Graziano, Giorgio; Lei, Haotian; Ciancone, Anthony M.; Kumar, Ashish; Holewinski, Ronald; Neufeld, Edward B.; O'Reilly, Francis J.; Remaley, Alan T.; Marcotrigiano, Joseph
作者单位：National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research
摘要：Apolipoprotein B100 (apoB100) is a structural component of low-density lipoprotein (LDL) and a ligand for the LDL receptor (LDLR)1. Mutations in apoB100 or in LDLR cause familial hypercholesterolaemia, an autosomal dominant disease that is characterized by a marked increase in LDL cholesterol (LDL-C) and a higher risk of cardiovascular disease2. The structure of apoB100 on LDL and its interaction with LDLR are poorly understood. Here we present the cryo-electron microscopy structures of apoB10...
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作者：Reardon, Sara
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作者：Smolsky, Joseph; Leach, Kyle G.; Abells, Ryan; Amaro, Pedro; Andoche, Adrien; Borbridge, Keith; Bray, Connor; Cantor, Robin; Diercks, David; Fretwell, Spencer; Friedrich, Stephan; Gillespie, Abigail; Guerra, Mauro; Hall, Ad; Harris, Cameron N.; Harris, Jackson T.; Hayen, Leendert M.; Hervieux, Paul-Antoine; Hinkle, Calvin; Kim, Geon-Bo; Kim, Inwook; Lamm, Amii; Lennarz, Annika; Lordi, Vincenzo; Machado, Jorge; Marino, Andrew; Mckeen, David; Mougeot, Xavier; Ponce, Francisco; Ruiz, Chris; Samanta, Amit; Santos, Jose Paulo; Stone-Whitehead, Caitlyn; Taylor, John; Templet, Joseph; Upadhyayula, Sriteja; Wagner, Louis; Warburton, William K.
作者单位：Colorado School of Mines; Michigan State University; University of British Columbia; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Colorado School of Mines; Universite de Caen Normandie; McMaster University; Universite Paris Saclay; CEA; United States Department of Energy (DOE); Pacific Northwest National Laboratory
摘要：Despite their high relative abundance in our Universe, neutrinos are the least understood fundamental particles of nature. In fact, the quantum properties of neutrinos emitted in experimentally relevant sources are theoretically contested1, 2, 3-4 and the spatial extent of the neutrino wavepacket is only loosely constrained by reactor neutrino oscillation data with a spread of 13 orders of magnitude5,6. Here we present a method to directly access this quantity by precisely measuring the energy...
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作者：Kanervisto, Anssi; Bignell, Dave; Wen, Linda Yilin; Grayson, Martin; Georgescu, Raluca; Macua, Sergio Valcarcel; Tan, Shan Zheng; Rashid, Tabish; Pearce, Tim; Cao, Yuhan; Lemkhenter, Abdelhak; Jiang, Chentian; Costello, Gavin; Gupta, Gunshi; Tot, Marko; Ishida, Shu; Gupta, Tarun; Arora, Udit; White, Ryen W.; Devlin, Sam; Morrison, Cecily; Hofmann, Katja
作者单位：Microsoft; Microsoft United Kingdom; University of Edinburgh; University of Oxford; University of London; Queen Mary University London; Microsoft
摘要：Generative artificial intelligence (AI) has the potential to transform creative industries through supporting human creative ideation-the generation of new ideas1, 2, 3, 4-5. However, limitations in model capabilities raise key challenges in integrating these technologies more fully into creative practices. Iterative tweaking and divergent thinking remain key to enabling creativity support using technology6,7, yet these practices are insufficiently supported by state-of-the-art generative AI m...
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作者：Wu, Chengcheng; Lin, Fengxiang; Liu, Hong; Pelletier, Matthew H.; Lloyd, Max; Walsh, Williams R.; Nie, Jian-Feng
作者单位：Monash University; Karlstad University; Shanghai Jiao Tong University; University of New South Wales Sydney
摘要：Zinc is emerging as a key material for next-generation biodegradable implants1, 2, 3, 4-5. However, its inherent softness limits its use in load-bearing orthopaedic implants. Although reducing the grain size of zinc can make it stronger, it also destabilizes its mechanical properties and thus makes it less durable at body temperature6. Here we show that extruded Zn alloys of dilute compositions can achieve ultrahigh strength and excellent durability when their micron-scale grain size is increa...
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作者：Brazil, Rachel
