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作者：Cook, Nicola M.; Gobbato, Giulia; Jacott, Catherine N.; Marchal, Clemence; Hsieh, Chen Yun; Lam, Anson Ho Ching; Simmonds, James; del Cerro, Pablo; Gomez, Pilar Navarro; Rodney, Clemence; Cruz-Mireles, Neftaly; Uauy, Cristobal; Haerty, Wilfried; Lawson, David M.; Charpentier, Myriam
作者单位：UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Earlham Institute; University of Sevilla; Eberhard Karls University of Tubingen; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Pablo de Olavide; CSIC - Andalusian Center for Developmental Biology (CABD); University of East Anglia; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center
摘要：Nutrient acquisition is crucial for sustaining life. Plants develop beneficial intracellular partnerships with arbuscular mycorrhiza (AM) and nitrogen-fixing bacteria to surmount the scarcity of soil nutrients and tap into atmospheric dinitrogen, respectively1,2. Initiation of these root endosymbioses requires symbiont-induced oscillations in nuclear calcium (Ca2+) concentrations in root cells3. How the nuclear-localized ion channels, cyclic nucleotide-gated channel (CNGC) 15 and DOESN'T MAKE ...
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作者：Hutskalova, Valeriia; Sparr, Christof
作者单位：University of Basel
摘要：Aromatic compounds are used across chemistry and materials science as a result of their stability, characteristic interactions, defined molecular shape and the numerous approaches for their synthesis by a diversity of cyclization reactions1. By contrast, the cleavage of inert aromatic carbon-carbon bonds remained largely unfeasible owing to the unfavourable energetics of disrupting aromaticity on ring opening. For non-aromatic structures, alkene metathesis catalysed by transition-metal alkylid...
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作者：Schwaller, Fred
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作者：Claudet, Joachim; Blythe, Jessica; Gill, David
作者单位：Centre National de la Recherche Scientifique (CNRS); Brock University; Duke University
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作者：Marr, Linsey C.
作者单位：Virginia Polytechnic Institute & State University
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作者：Sobarzo, Juan Carlos; Pertl, Felix; Balazs, Daniel M.; Costanzo, Tommaso; Sauer, Markus; Foelske, Annette; Ostermann, Markus; Pichler, Christian M.; Wang, Yongkang; Nagata, Yuki; Bonn, Mischa; Waitukaitis, Scott
作者单位：Institute of Science & Technology - Austria; Technische Universitat Wien; Max Planck Society
摘要：When two insulating, neutral materials are contacted and separated, they exchange electrical charge1. Experiments have long suggested that this 'contact electrification' is transitive, with different materials ordering into 'triboelectric series' based on the sign of charge acquired2. At the same time, the effect is plagued by unpredictability, preventing consensus on the mechanism and casting doubt on the rhyme and reason that series imply3. Here we expose an unanticipated connection between ...
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作者：Xiao, Xun; Xu, Niansheng; Tian, Xueyu; Zhang, Tiankai; Wang, Bingzheng; Wang, Xiaoming; Xian, Yeming; Lu, Chunyuan; Ou, Xiangyu; Yan, Yanfa; Sun, Licheng; You, Fengqi; Gao, Feng
作者单位：Linkoping University; Cornell University; University System of Ohio; University of Toledo; University System of Ohio; University of Toledo; Westlake University; Westlake University; Westlake University; Baima Lake Laboratory; Cornell University; Cornell University; Linkoping University
摘要：Cumulative silicon photovoltaic (PV) waste highlights the importance of considering waste recycling before the commercialization of emerging PV technologies1,2. Perovskite PVs are a promising next-generation technology3, in which recycling their end-of-life waste can reduce the toxic waste and retain resources4,5. Here we report a low-cost, green-solvent-based holistic recycling strategy to restore all valuable components from perovskite PV waste. We develop an efficient aqueous-based perovski...
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作者：Piraner, Dan I.; Abedi, Mohamad H.; Duran Gonzalez, Maria J.; Chazin-Gray, Adam; Lin, Annie; Zhu, Iowis; Ravindran, Pavithran T.; Schlichthaerle, Thomas; Huang, Buwei; Bearchild, Tyler H.; Lee, David; Wyman, Sarah; Jun, Young-wook; Baker, David; Roybal, Kole T.
作者单位：University of California System; University of California San Francisco; University of Washington; University of Washington Seattle; University of California System; University of California San Francisco; University of California System; University of California Berkeley; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; Chan Zuckerberg Initiative (CZI); University of Pennsylvania
摘要：Despite recent advances in mammalian synthetic biology, there remains a lack of modular synthetic receptors that can robustly respond to soluble ligands and, in turn, activate bespoke cellular functions. Such receptors would have extensive clinical potential to regulate the activity of engineered therapeutic cells, but so far only receptors against cell-surface targets have approached clinical translation1. To address this gap, here we adapt a receptor architecture called the synthetic intrame...
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作者：Zhao, Yutong; Xu, Chaoyi; Yu, Xiaoyu; Liu, Yigang; Ji, Xinhui
作者单位：Chinese Academy of Sciences; Institute of Tibetan Plateau Research, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
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作者：Hu, Yan; Horlbeck, Max A.; Zhang, Ruochi; Ma, Sai; Shrestha, Rojesh; Kartha, Vinay K.; Duarte, Fabiana M.; Hock, Conrad; Savage, Rachel E.; Labade, Ajay; Kletzien, Heidi; Meliki, Alia; Castillo, Andrew; Durand, Neva C.; Mattei, Eugenio; Anderson, Lauren J.; Tay, Tristan; Earl, Andrew S.; Shoresh, Noam; Epstein, Charles B.; Wagers, Amy J.; Buenrostro, Jason D.
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Icahn School of Medicine at Mount Sinai
摘要：Cis-regulatory elements (CREs) control gene expression and are dynamic in their structure and function, reflecting changes in the composition of diverse effector proteins over time1. However, methods for measuring the organization of effector proteins at CREs across the genome are limited, hampering efforts to connect CRE structure to their function in cell fate and disease. Here we developed PRINT, a computational method that identifies footprints of DNA-protein interactions from bulk and sin...
