2025

最新文章

• China's low-altitude economy needs to grow with more caution AI翻译
  作者：Wang, Yong; Ran, Dexin
  作者单位：Qingdao University of Technology
• Transcriptomic neuron types vary topographically in function and morphology AI翻译
  作者：Shainer, Inbal; Kappel, Johannes M.; Laurell, Eva; Donovan, Joseph C.; Schneider, Martin W.; Kuehn, Enrico; Arnold-Ammer, Irene; Stemmer, Manuel; Larsch, Johannes; Baier, Herwig
  作者单位：Technion Israel Institute of Technology; Friedrich Miescher Institute for Biomedical Research; University of Lausanne
  摘要：Neuronal phenotypic traits such as morphology, connectivity and function are dictated, to a large extent, by a specific combination of differentially expressed genes. Clusters of neurons in transcriptomic space correspond to distinct cell types and in some cases-for example, Caenorhabditis elegans neurons1 and retinal ganglion cells2, 3-4-have been shown to share morphology and function. The zebrafish optic tectum is composed of a spatial array of neurons that transforms visual inputs into mot...
• A cell atlas foundation model for scalable search of similar human cells AI翻译
  作者：Heimberg, Graham; Kuo, Tony; Depianto, Daryle J.; Salem, Omar; Heigl, Tobias; Diamant, Nathaniel; Scalia, Gabriele; Biancalani, Tommaso; Turley, Shannon J.; Rock, Jason R.; Bravo, Hector Corrada; Kaminker, Josh; Vander Heiden, Jason A.; Regev, Aviv
  作者单位：Roche Holding; Roche Holding USA; Genentech; Roche Holding; Roche Holding USA; Genentech; Roche Holding; Roche Holding USA; Genentech; Roche Holding; Genentech; Roche Holding USA; Roche Holding; Roche Holding USA; Genentech
  摘要：Single-cell RNA sequencing has profiled hundreds of millions of human cells across organs, diseases, development and perturbations to date. Mining these growing atlases could reveal cell-disease associations, identify cell states in unexpected tissue contexts and relate in vivo biology to in vitro models. These require a common measure of cell similarity across the body and an efficient way to search. Here we develop SCimilarity, a metric-learning framework to learn a unified and interpretable...
• Learn COVID pandemic lessons - before it's too late AI翻译
  作者：[Anonymous]
• Does a cell's gene expression always reflect its function? AI翻译
  作者：Ozel, M. Neset; Desplan, Claude
  作者单位：Stowers Institute for Medical Research; New York University
• Synthetic lethality of mRNA quality control complexes in cancer AI翻译
  作者：Prindle, Vivian; Richardson, Adam E.; Sher, Kimberly R.; Kongpachith, Sarah; Kentala, Kaitlin; Petiwala, Sakina; Cheng, Dong; Widomski, Deborah; Le, Phuong; Torrent, Maricel; Chen, Anlu; Walker, Stephen; Palczewski, Marianne B.; Mitra, Diya; Manaves, Vlasios; Shi, Xu; Lu, Charles; Sandoval, Stephanie; Dezso, Zoltan; Buchanan, F. Gregory; Verduzco, Daniel; Bierie, Brian; Meulbroek, Jonathan A.; Pappano, William N.; Plotnik, Joshua P.
  作者单位：AbbVie
  摘要：Synthetic lethality exploits the genetic vulnerabilities of cancer cells to enable a targeted, precision approach to treat cancer1. Over the past 15 years, synthetic lethal cancer target discovery approaches have led to clinical successes of PARP inhibitors2 and ushered several next-generation therapeutic targets such as WRN3, USP14, PKMYT15, POLQ6 and PRMT57 into the clinic. Here we identify, in human cancer, a novel synthetic lethal interaction between the PELO-HBS1L and SKI complexes of the...
• Total synthesis of 25 picrotoxanes by virtual library selection AI翻译
  作者：Li, Chunyu; Shenvi, Ryan A.
  作者单位：Scripps Research Institute; Scripps Research Institute
  摘要：The synthesis of a complex molecule begins from an initial design stage1, 2, 3-4 in which possible routes are triaged by strategy and feasibility, on the basis of analogy to similar reactions2,3. However, as molecular complexity increases, predictability decreases5; inevitably, even experienced chemists resort to trial and error to identify viable intermediates en route to the target molecule. We encountered such a problem in the synthesis of picrotoxane sesquiterpenes in which pattern-recogni...
• Widespread occurrence and relevance of phosphate storage in foraminifera AI翻译
  作者：Glock, Nicolaas; Richirt, Julien; Woehle, Christian; Algar, Christopher; Armstrong, Maria; Eichner, Daniela; Firrincieli, Hanna; Makabe, Akiko; Menon, Anjaly Govindankutty; Ishitani, Yoshiyuki; Hackl, Thomas; Hubert-Huard, Raphael; Kienast, Markus; Milker, Yvonne; Mutzberg, Andre; Ni, Sha; Okada, Satoshi; Rakshit, Subhadeep; Schmiedl, Gerhard; Steiner, Zvi; Tame, Akihiro; Zhang, Zhouling; Nomaki, Hidetaka
  作者单位：University of Hamburg; Japan Agency for Marine-Earth Science & Technology (JAMSTEC); University of Kiel; Dalhousie University; University of Hamburg; University of Hamburg; Helmholtz Association; GEOMAR Helmholtz Center for Ocean Research Kiel; University of Fukui
  摘要：Foraminifera are ubiquitous marine protists that intracellularly accumulate phosphate1, an important macronutrient in marine ecosystems and in fertilizer potentially leaked into the ocean. Intracellular phosphate concentrations can be 100-1,000 times higher than in the surrounding water1. Here we show that phosphate storage in foraminifera is widespread, from tidal flats to the deep sea. The total amount of intracellular phosphate stored in the benthic foraminifer Ammonia confertitesta in the ...
• GZMK-expressing CD8+ T cells promote recurrent airway inflammatory diseases (JAN, 10.1038/s41586-024-08395-9, 2025) AI翻译
  作者：Lan, Feng; Li, Jizhou; Miao, Wenxuan; Sun, Fei; Duan, Su; Song, Yabing; Yao, Jiacheng; Wang, Xiangdong; Wang, Chengshuo; Liu, Xin; Wang, Jianbin; Zhang, Luo; Qi, Hai
• Reply to: Streamflow shifts with declining snowfall AI翻译
  作者：Han, Juntai; Liu, Ziwei; Yang, Yuting
  作者单位：Tsinghua University