2025

最新文章

• Revealed: NIH research grants still frozen despite lawsuits challenging Trump order AI翻译
  作者：Kozlov, Max
  摘要：The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.
• A lightweight shape-memory alloy with superior temperature-fluctuation resistance AI翻译
  作者：Song, Yuxin; Xu, Sheng; Sato, Shunsuke; Lee, Inho; Xu, Xiao; Omori, Toshihiro; Nagasako, Makoto; Kawasaki, Takuro; Kiyanagi, Ryoji; Harjo, Stefanus; Gong, Wu; Grabec, Tomas; Stoklasova, Pavla; Kainuma, Ryosuke
  作者单位：Tohoku University; Tohoku University; Tohoku University; Japan Atomic Energy Agency; Czech Academy of Sciences; Institute of Thermomechanics of the Czech Academy of Sciences
  摘要：In advanced applications such as aerospace and space exploration, materials must balance lightness, functionality and extreme thermal fluctuation resistance1,2. Shape-memory alloys show promise with strength, toughness and substantial strain recovery due to superelasticity, but maintaining low mass and effective operation at cryogenic temperatures is challenging3, 4, 5-6. We hereby introduce a new shape-memory alloy that adheres to these stringent criteria. Predominantly composed of Ti and Al ...
• Superelastic titanium alloy has potential for space missions AI翻译
  作者：Wei, Shaolou; Raabe, Dierk
• SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO AI翻译
  作者：Borck, Patricia C.; Boyle, Isabella; Jankovic, Kristina; Bick, Nolan; Foster, Kyla; Lau, Anthony C.; Parker-Burns, Lucy I.; Lubicki, Daniel A.; Li, Tianxia; Borah, Ashir A.; Lofaso, Nicholas J.; Das Sharma, Sohani; Chan, Tessla; Kishen, Riya V.; Adeagbo, Anisah; Raghavan, Srivatsan; Aquilanti, Elisa; Prensner, John R.; Krill-Burger, J. Michael; Golub, Todd R.; Campbell, Catarina D.; Dempster, Joshua M.; Chan, Edmond M.; Vazquez, Francisca
  作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; NewYork-Presbyterian Hospital; Columbia University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard Medical School; University of Michigan System; University of Michigan; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; NewYork-Presbyterian Hospital; Columbia University
  摘要：Cancer genome alterations often lead to vulnerabilities that can be used to selectively target cancer cells. Various inhibitors of such synthetic lethal targets have been approved by the FDA or are in clinical trials, highlighting the potential of this approach1, 2-3. Here we analysed large-scale CRISPR knockout screening data from the Cancer Dependency Map and identified a new synthetic lethal target, PELO, for two independent molecular subtypes of cancer: biallelic deletion of chromosomal re...
• Signatures of ambient pressure superconductivity in thin film La3Ni2O7 AI翻译
  作者：Ko, Eun Kyo; Yu, Yijun; Liu, Yidi; Bhatt, Lopa; Li, Jiarui; Thampy, Vivek; Kuo, Cheng-Tai; Wang, Bai Yang; Lee, Yonghun; Lee, Kyuho; Lee, Jun-Sik; Goodge, Berit H.; Muller, David A.; Hwang, Harold Y.
  作者单位：Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; Stanford University; Cornell University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Max Planck Society; Cornell University
  摘要：Recently, the bilayer nickelate La3Ni2O7 has been discovered as a new superconductor with transition temperature Tc near 80 K under high pressure1, 2-3. Despite extensive theoretical and experimental work to understand the nature of its superconductivity4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28-29, the requirement of extreme pressure restricts the use of many experimental probes and limits its application potential. Here we present signatures ...
• Can AI help beat poverty? Researchers test ways to aid the poorest people AI翻译
  作者：Arnold, Carrie
• Causal claims, causal assumptions and protected area impact AI翻译
  作者：Geldmann, Jonas; Jones, Julia P. G.; Wauchope, Hannah; Ferraro, Paul J.
  作者单位：University of Copenhagen; Bangor University; Utrecht University; University of Edinburgh; Johns Hopkins University; Johns Hopkins University
• Learned magnetic map cues and two mechanisms of magnetoreception in turtles AI翻译
  作者：Goforth, Kayla M.; Lohmann, Catherine M. F.; Gavin, Andrew; Henning, Reyco; Harvey, Andrew; Hinton, Tara L.; Lim, Dana S.; Lohmann, Kenneth J.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Texas A&M University System; Texas A&M University College Station
  摘要：Growing evidence indicates that migratory animals exploit the magnetic field of the Earth for navigation, both as a compass to determine direction and as a map to determine geographical position1. It has long been proposed that, to navigate using a magnetic map, animals must learn the magnetic coordinates of the destination2,3, yet the pivotal hypothesis that animals can learn magnetic signatures of geographical areas has, to our knowledge, yet to be tested. Here we report that an iconic navig...
• Move beyond 'publish or perish' by measuring behaviours that benefit academia AI翻译
  作者：Allen, Kelly-Ann
  作者单位：Monash University
  摘要：A standardized system to measure scientists' contributions in mentorship, collaboration and more could bring about systemic change.
• Discovery and engineering of the antibody response to a prominent skin commensal AI翻译
  作者：Bousbaine, Djenet; Bauman, Katherine D.; Chen, Y. Erin; Lalgudi, Pranav V.; Nguyen, Tam T. D.; Swenson, Joyce M.; Yu, Victor K.; Tsang, Eunice; Conlan, Sean; Li, David B.; Jbara, Amina; Zhao, Aishan; Naziripour, Arash; Veinbachs, Alessandra; Lee, Yu E.; Phung, Jennie L.; Dimas, Alex; Jain, Sunit; Meng, Xiandong; Pham, Thi Phuong Thao; Mclaughlin, Martin I.; Barkal, Layla J.; Gribonika, Inta; Van Rompay, Koen K. A.; Kong, Heidi H.; Segre, Julia A.; Belkaid, Yasmine; Barnes, Christopher O.; Fischbach, Michael A.
  作者单位：Stanford University; Stanford University; Stanford University; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); Stanford University; Chan Zuckerberg Initiative (CZI); Stanford University; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); University of California System; University of California Davis; University of California System; University of California Davis; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS)
  摘要：The ubiquitous skin colonist Staphylococcus epidermidis elicits a CD8+ T cell response pre-emptively, in the absence of an infection1. However, the scope and purpose of this anticommensal immune programme are not well defined, limiting our ability to harness it therapeutically. Here, we show that this colonist also induces a potent, durable and specific antibody response that is conserved in humans and non-human primates. A series of S. epidermidis cell-wall mutants revealed that the cell surf...