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作者：Kozlov, Max; Mallapaty, Smriti
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作者：Pasca, Sergiu P.; Arlotta, Paola; Bateup, Helen S.; Camp, J. Gray; Cappello, Silvia; Gage, Fred H.; Knoblich, Juergen A.; Kriegstein, Arnold R.; Lancaster, Madeline A.; Ming, Guo-Li; Novarino, Gaia; Okano, Hideyuki; Parmar, Malin; Park, In-Hyun; Reiner, Orly; Song, Hongjun; Studer, Lorenz; Takahashi, Jun; Temple, Sally; Testa, Giuseppe; Treutlein, Barbara; Vaccarino, Flora M.; Vanderhaeghen, Pierre; Young-Pearse, Tracy
作者单位：Stanford University; Stanford University; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Roche Holding; University of Basel; University of Munich; Max Planck Society; Salk Institute; Vienna Biocenter (VBC); Institute of Molecular Biotechnology (IMBA); Austrian Academy of Sciences; Medical University of Vienna; University of California System; University of California San Francisco; University of California System; University of California San Francisco; MRC Laboratory Molecular Biology; University of Cambridge; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Institute of Science & Technology - Austria; Keio University; Lund University; Yale University; Yale University; Weizmann Institute of Science; Weizmann Institute of Science; University of Pennsylvania; Memorial Sloan Kettering Cancer Center; Kyoto University; University of Milan; Human Technopole; Yale University; Yale University; Flanders Institute for Biotechnology (VIB); Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University
摘要：As the field of neural organoids and assembloids expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and utility of these models. In this Perspective, we present a framework for the experimental process that encompasses ensuring the quality and integrity of human pluripotent stem cells, characterizing and manipulating neural cells in vitro, transplantation techniques and considerations for modelling human...
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作者：Marchand, Anthony; Buckley, Stephen; Schneuing, Arne; Pacesa, Martin; Elia, Maddalena; Gainza, Pablo; Elizarova, Evgenia; Neeser, Rebecca M.; Lee, Pao-Wan; Reymond, Luc; Miao, Yangyang; Scheller, Leo; Georgeon, Sandrine; Schmidt, Joseph; Schwaller, Philippe; Maerkl, Sebastian J.; Bronstein, Michael; Correia, Bruno E.
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss School of Public Health (SSPH+); University of Oxford; Austrian Academy of Sciences
摘要：Molecular recognition events between proteins drive biological processes in living systems1. However, higher levels of mechanistic regulation have emerged, in which protein-protein interactions are conditioned to small molecules2, 3, 4-5. Despite recent advances, computational tools for the design of new chemically induced protein interactions have remained a challenging task for the field6,7. Here we present a computational strategy for the design of proteins that target neosurfaces, that is,...
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作者：Nowogrodzki, Julian
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作者：Sanchez-Yamagishi, Javier
作者单位：University of California System; University of California Irvine
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作者：Trypogeorgos, Dimitrios; Gianfrate, Antonio; Landini, Manuele; Nigro, Davide; Gerace, Dario; Carusotto, Iacopo; Riminucci, Fabrizio; Baldwin, Kirk W.; Pfeiffer, Loren N.; Martone, Giovanni I.; De Giorgi, Milena; Ballarini, Dario; Sanvitto, Daniele
作者单位：Consiglio Nazionale delle Ricerche (CNR); Istituto di Nanotecnologia (NANOTEC-CNR); University of Innsbruck; Consiglio Nazionale delle Ricerche (CNR); Istituto Nazionale di Ottica (INO-CNR); University of Trento; University of Trento; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Princeton University
摘要：A supersolid is a counter-intuitive phase of matter in which its constituent particles are arranged into a crystalline structure, yet they are free to flow without friction. This requires the particles to share a global macroscopic phase while being able to reduce their total energy by spontaneous, spatial self-organization. The existence of the supersolid phase of matter was speculated more than 50 years ago1, 2, 3-4. However, only recently has there been convincing experimental evidence, mai...
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作者：Wiebe, R. Alex; Wilcove, David S.
作者单位：Princeton University; Princeton University; Princeton University
摘要：Globalization increasingly allows countries to externalize the environmental costs of land use, including biodiversity loss1. So far, we have a very incomplete understanding of how countries cause biodiversity loss outside their own borders through their demand for agricultural and forestry products grown in other countries2. Here we quantify the global range losses to forest vertebrates from 2001 to 2015 caused by deforestation attributable to 24 developed countries by means of their consumpt...
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作者：Kokontis, Claire; Klein, Timothy A.; Silas, Sukrit; Bondy-Denomy, Joseph
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要：Bacteriophages use diverse mechanisms to evade antiphage defence systems. Phi KZ-like jumbo phages assemble a proteinaceous, nucleus-like compartment that excludes antagonistic host nucleases and also internalizes DNA replication and transcription machinery1, 2, 3-4. The phage factors required for protein import and the mechanisms of selectivity remain unknown, however. Here we uncover an import system comprising proteins highly conserved across nucleus-forming phages, together with additional...
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作者：Mallapaty, Smriti
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作者：Arbour, Laura
作者单位：University of British Columbia
摘要：A study involving 14% of the people in Greenland makes a case for including under-represented groups in population genomics data - which could reduce inequalities in genetics-based clinical care and personalized medicine.
