2025

最新文章

• Who's likely to wake up from a coma? Brainwaves provide a clue AI翻译
  作者：[Anonymous]
• Why women's brains are more resilient: it could be their 'silent' X chromosome AI翻译
  作者：Bourzac, Katherine
• Realization of 2D metals at the ångström thickness limit AI翻译
  作者：Zhao, Jiaojiao; Li, Lu; Li, Peixuan; Dai, Liyan; Dong, Jingwei; Zhou, Lanying; Wang, Yizhe; Zhang, Peihang; Ji, Kunshan; Zhang, Yangkun; Yu, Hua; Wei, Zheng; Li, Jiawei; Li, Xiuzhen; Huang, Zhiheng; Wang, Boxin; Liu, Jieying; Chen, Yutong; Zhang, Xingchao; Wang, Shuopei; Li, Na; Yang, Wei; Shi, Dongxia; Pan, Jinbo; Du, Shixuan; Du, Luojun; Zhang, Guangyu
  作者单位：Chinese Academy of Sciences; Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Songshan Lake Materials Laboratory
  摘要：Two-dimensional (2D) metals are appealing for many emergent phenomena and have recently attracted research interests1, 2, 3, 4, 5, 6, 7, 8-9. Unlike the widely studied 2D van der Waals (vdW) layered materials, 2D metals are extremely challenging to achieve, because they are thermodynamically unstable1,10. Here we develop a vdW squeezing method to realize diverse 2D metals (including Bi, Ga, In, Sn and Pb) at the & aring;ngstr & ouml;m thickness limit. The achieved 2D metals are stabilized from...
• Engineering a genomically recoded organism with one stop codon AI翻译
  作者：Grome, Michael W.; Nguyen, Michael T. A.; Moonan, Daniel W.; Mohler, Kyle; Gurara, Kebron; Wang, Shenqi; Hemez, Colin; Stenton, Benjamin J.; Cao, Yunteng; Radford, Felix; Kornaj, Maya; Patel, Jaymin; Prome, Maisha; Rogulina, Svetlana; Sozanski, David; Tordoff, Jesse; Rinehart, Jesse; Isaacs, Farren J.
  作者单位：Yale University; Yale University; Yale University; Yale University; Yale University
  摘要：The genetic code is conserved across all domains of life, yet exceptions have revealed variations in codon assignments and associated translation factors1, 2-3. Inspired by this natural malleability, synthetic approaches have demonstrated whole-genome replacement of synonymous codons to construct genomically recoded organisms (GROs)4,5 with alternative genetic codes. However, no efforts have fully leveraged translation factor plasticity and codon degeneracy to compress translation function to ...
• An operating system for networked quantum computers is a huge practical step forward AI翻译
  作者：Cicconetti, Claudio
  作者单位：Consiglio Nazionale delle Ricerche (CNR); Istituto di Informatica e Telematica (IIT-CNR)
• 'Silence is complicity' - universities must fight the anti-DEI crackdown AI翻译
  作者：Rodriguez, Rebecca Calisi
  作者单位：University of California System; University of California Davis
• Are microplastics bad for your health? More rigorous science is needed AI翻译
  作者：Xu, Jun-Li; Wright, Stephanie; Rauert, Cassandra; Thomas, Kevin V.
  作者单位：University College Dublin; Imperial College London; University of Queensland
• The Ronne Ice Shelf survived the last interglacial (vol 638, pg 133, 2025) AI翻译
  作者：Wolff, Eric W.; Mulvaney, Robert; Grieman, Mackenzie M.; Hoffmann, Helene M.; Humby, Jack; Nehrbass-Ahles, Christoph; Rhodes, Rachael H.; Rowell, Isobel F.; Sime, Louise C.; Fischer, Hubertus; Stocker, Thomas F.; Landais, Amaelle; Parrenin, Frederic; Steig, Eric J.; Duetsch, Marina; Golledge, Nicholas R.
• Ancient puppets that smile or scowl hint at shared rituals AI翻译
  作者：[Anonymous]
• Tumour-wide RNA splicing aberrations generate actionable public neoantigens AI翻译
  作者：Kwok, Darwin W.; Stevers, Nicholas O.; Etxeberria, Inaki; Nejo, Takahide; Cove, Maggie Colton; Chen, Lee H.; Jung, Jangham; Okada, Kaori; Lakshmanachetty, Senthilnath; Gallus, Marco; Barpanda, Abhilash; Hong, Chibo; Chan, Gary K. L.; Liu, Jerry; Wu, Samuel H.; Ramos, Emilio; Yamamichi, Akane; Watchmaker, Payal B.; Ogino, Hirokazu; Saijo, Atsuro; Du, Aidan; Grishanina, Nadia R.; Woo, James; Diaz, Aaron; Hervey-Jumper, Shawn L.; Chang, Susan M.; Phillips, Joanna J.; Wiita, Arun P.; Klebanoff, Christopher A.; Costello, Joseph F.; Okada, Hideho
  作者单位：University of California System; University of California San Francisco; Memorial Sloan Kettering Cancer Center; University of Munster; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Chan Zuckerberg Initiative (CZI); Memorial Sloan Kettering Cancer Center
  摘要：T cell-based immunotherapies hold promise in treating cancer by leveraging the immune system's recognition of cancer-specific antigens1. However, their efficacy is limited in tumours with few somatic mutations and substantial intratumoural heterogeneity2, 3-4. Here we introduce a previously uncharacterized class of tumour-wide public neoantigens originating from RNA splicing aberrations in diverse cancer types. We identified T cell receptor clones capable of recognizing and targeting neoantige...