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作者：Muller, Miryam; May, Stephanie; Hall, Holly; Kendall, Timothy J.; Mcgarry, Lynn; Blukacz, Lauriane; Nuciforo, Sandro; Georgakopoulou, Anastasia; Jamieson, Thomas; Phinichkusolchit, Narisa; Dhayade, Sandeep; Suzuki, Toshiyasu; Huguet-Pradell, Julia; Powley, Ian R.; Officer-Jones, Leah; Pennie, Rachel L.; Esteban-Fabro, Roger; Gris-Oliver, Albert; Pinyol, Roser; Skalka, George L.; Leslie, Jack; Hoare, Matthew; Sprangers, Joep; Malviya, Gaurav; Mackintosh, Agata; Johnson, Emma; Mccain, Misti; Halpin, John; Kiourtis, Christos; Nixon, Colin; Clark, Graeme; Clark, William; Shaw, Robin; Hedley, Ann; Drake, Thomas M.; Tan, Ee Hong; Neilson, Matt; Murphy, Daniel J.; Lewis, David Y.; Reeves, Helen L.; Le Quesne, John; Mann, Derek A.; Carlin, Leo M.; Blyth, Karen; Llovet, Josep M.; Heim, Markus H.; Sansom, Owen J.; Miller, Crispin J.; Bird, Thomas G.
作者单位：University of Glasgow; University of Edinburgh; University of Basel; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Newcastle University - UK; Newcastle University - UK; University of Cambridge; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of Cambridge; University of Edinburgh; Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust; Queen Elizabeth University Hospital (QEUH); Koc University; Icahn School of Medicine at Mount Sinai; ICREA
摘要：Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, is a leading cause of cancer-related mortality worldwide1,2. HCC occurs typically from a background of chronic liver disease, caused by a spectrum of predisposing conditions. Tumour development is driven by the expansion of clones that accumulate progressive driver mutations3, with hepatocytes the most likely cell of origin2. However, the landscape of driver mutations in HCC is broadly independent of the underlying a...
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作者：Yamada, Tatsuya; Ikeda, Arisa; Murata, Daisuke; Wang, Hu; Zhang, Cissy; Khare, Pratik; Adachi, Yoshihiro; Ito, Fumiya; Quiros, Pedro M.; Blackshaw, Seth; Lopez-Otin, Carlos; Langer, Thomas; Chan, David C.; Le, Anne; Dawson, Valina L.; Dawson, Ted M.; Iijima, Miho; Sesaki, Hiromi
作者单位：Johns Hopkins University; University of Nebraska System; University of Nebraska Lincoln; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; University of Oviedo; Instituto Universitario de Oncologia de Asturias; Johns Hopkins University; Max Planck Society; California Institute of Technology; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Sorbonne Universite; Universidad Antonio de Nebrija
摘要：Mitochondrial stress pathways protect mitochondrial health from cellular insults1, 2, 3, 4, 5, 6, 7-8. However, their role under physiological conditions is largely unknown. Here, using 18 single, double and triple whole-body and tissue-specific knockout and mutant mice, along with systematic mitochondrial morphology analysis, untargeted metabolomics and RNA sequencing, we discovered that the synergy between two stress-responsive systems-the ubiquitin E3 ligase Parkin and the metalloprotease O...
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作者：Thiruppathy, Mathi; Teubner, Lauren; Roberts, Ryan R.; Lasser, Micaela C.; Moscatello, Alessandra; Chen, Ya-Wen; Hochstim, Christian; Ruffins, Seth; Sarkar, Arijita; Tassey, Jade; Evseenko, Denis; Lozito, Thomas P.; Willsey, Helen Rankin; Gillis, J. Andrew; Crump, J. Gage
作者单位：University of Southern California; University of California System; University of California San Francisco; New York Medical College; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Children's Hospital Los Angeles; University of Southern California; University of Southern California; Chan Zuckerberg Initiative (CZI); Marine Biological Laboratory - Woods Hole
摘要：How new structures emerge during evolution has long fascinated biologists. An example is how the diminutive bones of the mammalian middle ear arose from ancestral fish jawbones1. By contrast, the evolutionary origin of the outer ear, another mammalian innovation, remains a mystery, partly because it is supported by non-mineralized elastic cartilage, which is rarely recovered in fossils. Whether the outer ear arose de novo or through the reuse of ancestral developmental programs has remained un...
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作者：Baker, Simon
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作者：Bolton, Patrick; Edenhofer, Ottmar; Kleinnijenhuis, Alissa; Rockstroem, Johan; Zettelmeyer, Jeromin
作者单位：Imperial College London; Imperial College London; Potsdam Institut fur Klimafolgenforschung; Technical University of Berlin; Technical University of Berlin; Technical University of Berlin; Cornell University; Imperial College London; University of Potsdam
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作者：Ocaya, Richard O.; Malevu, Thembinkosi D.
作者单位：University of the Free State; North West University - South Africa
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作者：Nowogrodzki, Julian; Basilio, Humberto; Ledford, Heidi; Maher, Brendan; Witze, Alexandra
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作者：Khwa, Win-San; Wen, Tai-Hao; Hsu, Hung-Hsi; Huang, Wei-Hsing; Chang, Yu-Chen; Chiu, Ting-Chien; Ke, Zhao-En; Chin, Yu-Hsiang; Wen, Hua-Jin; Hsu, Wei-Ting; Lo, Chung-Chuan; Liu, Ren-Shuo; Hsieh, Chih-Cheng; Tang, Kea-Tiong; Ho, Mon-Shu; Lele, Ashwin Sanjay; Teng, Shih-Hsin; Chou, Chung-Cheng; Chih, Yu-Der; Chang, Tsung-Yung Jonathan; Chang, Meng-Fan
作者单位：Taiwan Semiconductor Manufacturing Company; Taiwan Semiconductor Manufacturing Company
摘要：Artificial intelligence (AI) edge devices(1-12) demand high-precision energy-efficient computations, large on-chip model storage, rapid wakeup-to-response time and cost-effective foundry-ready solutions. Floating point (FP) computation provides precision exceeding that of integer (INT) formats at the cost of higher power and storage overhead. Multi-level-cell (MLC) memristor compute-in-memory (CIM)(13-15) provides compact non-volatile storage and energy-efficient computation but is prone to ac...
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作者：Gaind, Nisha
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作者：Liu, Haoyu
作者单位：Hainan Normal University
