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作者：Terhaar, Jens; Burger, Friedrich A.; Vogt, Linus; Frolicher, Thomas L.; Stocker, Thomas F.
作者单位：University of Bern; University of Bern; Universite Paris Cite; Sorbonne Universite; Institut Polytechnique de Paris; Ecole Polytechnique; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Museum National d'Histoire Naturelle (MNHN)
摘要：Global ocean surface temperatures were at record levels for more than a year from April 2023 onwards, exceeding the previous record in 2015-2016 by 0.25 degrees C on average between April 2023 and March 20241. The nearly global extent and unprecedented intensity of this event prompted questions about how exceptional it was and whether climate models can represent such record-shattering jumps in surface ocean temperatures2. Here we construct observation-based synthetic time series to show that ...
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作者：Rao, Vishwanatha M.; Hla, Michael; Moor, Michael; Adithan, Subathra; Kwak, Stephen; Topol, Eric J.; Rajpurkar, Pranav
作者单位：Harvard University; Harvard Medical School; University of Pennsylvania; Harvard University; Stanford University; Swiss Federal Institutes of Technology Domain; ETH Zurich; Jawaharlal Institute of Postgraduate Medical Education & Research; Johns Hopkins University; Scripps Research Institute
摘要：Accurately interpreting medical images and generating insightful narrative reports is indispensable for patient care but places heavy burdens on clinical experts. Advances in artificial intelligence (AI), especially in an area that we refer to as multimodal generative medical image interpretation (GenMI), create opportunities to automate parts of this complex process. In this Perspective, we synthesize progress and challenges in developing AI systems for generation of medical reports from imag...
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作者：Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Hasan, Mohammad R.; Yassine, Hadi M.; Al Thani, Asmaa A.; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul-Rahim, Hanan F.; Nasrallah, Gheyath K.; Al-Kuwari, Mohamed Ghaith; Butt, Adeel A.; Al-Romaihi, Hamad Eid; Al-Thani, Mohamed H.; Al-Khal, Abdullatif; Bertollini, Roberto; Abu-Raddad, Laith J.
作者单位：Qatar Foundation (QF); Weill Cornell Medical College Qatar; Qatar Foundation (QF); Weill Cornell Medical College Qatar; Cornell University; Weill Cornell Medicine; Qatar University; Qatar University; Hamad Medical Corporation; Queens University Belfast; Sidra Medical & Research Center; McMaster University; Qatar University; Qatar University; Hamad Medical Corporation; Primary Health Care Corporation (PHCC); Cornell University; Weill Cornell Medicine; Qatar Foundation (QF); Hamad Bin Khalifa University-Qatar
摘要：The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly evolved over short timescales, leading to the emergence of more transmissible variants such as Alpha and Delta1, 2-3. The arrival of the Omicron variant marked a major shift, introducing numerous extra mutations in the spike gene compared with earlier variants1,2. These evolutionary changes have raised concerns regarding their potential impact on immune evasion, disease severity and the effectiveness of vaccines and t...
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作者：Sethna, Zachary; Guasp, Pablo; Reiche, Charlotte; Milighetti, Martina; Ceglia, Nicholas; Patterson, Erin; Lihm, Jayon; Payne, George; Lyudovyk, Olga; Rojas, Luis A.; Pang, Nan; Ohmoto, Akihiro; Amisaki, Masataka; Zebboudj, Abderezak; Odgerel, Zagaa; Bruno, Emmanuel M.; Zhang, Siqi Linsey; Cheng, Charlotte; Elhanati, Yuval; Derhovanessian, Evelyna; Manning, Luisa; Mueller, Felicitas; Rhee, Ina; Yadav, Mahesh; Merghoub, Taha; Wolchok, Jedd D.; Basturk, Olca; Goenen, Mithat; Epstein, Andrew S.; Momtaz, Parisa; Park, Wungki; Sugarman, Ryan; Varghese, Anna M.; Won, Elizabeth; Desai, Avni; Wei, Alice C.; D'Angelica, Michael I.; Kingham, T. Peter; Soares, Kevin C.; Jarnagin, William R.; Drebin, Jeffrey; O'Reilly, Eileen M.; Mellman, Ira; Sahin, Ugur; Tuereci, Oezlem; Greenbaum, Benjamin D.; Balachandran, Vinod P.
作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; BioNTech SE; Roche Holding; Genentech; Roche Holding USA; Cornell University; Weill Cornell Medicine; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine
摘要：A fundamental challenge for cancer vaccines is to generate long-lived functional T cells that are specific for tumour antigens. Here we find that mRNA-lipoplex vaccines against somatic mutation-derived neoantigens may solve this challenge in pancreatic ductal adenocarcinoma (PDAC), a lethal cancer with few mutations. At an extended 3.2-year median follow-up from a phase 1 trial of surgery, atezolizumab (PD-L1 inhibitory antibody), autogene cevumeran1 (individualized neoantigen vaccine with bac...
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作者：Wang, Rong; Chen, Baozhi; Elghobashi-Meinhardt, Nadia; Tie, Jian-Ke; Ayala, Alyssa; Zhou, Ning; Qi, Xiaofeng
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University College Dublin; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Texas System; University of Texas Southwestern Medical Center
摘要：gamma-Glutamyl carboxylase (GGCX) is the sole identified enzyme that uses vitamin K (VK) as a cofactor in humans. This protein catalyses the oxidation of VK hydroquinone to convert specific glutamate residues to gamma-carboxyglutamate residues in VK-dependent proteins (VDPs), which are involved in various essential biological processes and diseases1, 2-3. However, the working mechanism of GGCX remains unclear. Here we report three cryogenic electron microscopy structures of human GGCX: in the ...
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作者：[Anonymous]
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作者：Plackett, Benjamin
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作者：Rajagopal, Veera M.; Gelfman, Sahar
作者单位：Regeneron
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作者：Vicente-Serrano, Sergio M.; Tramblay, Yves; Reig, Fergus; Gonzalez-Hidalgo, Jose C.; Begueria, Santiago; Brunetti, Michele; Kalin, Ksenija Cindric; Patalen, Leonardo; Krzic, Aleksandra; Lionello, Piero; Lima, Miguel M.; Trigo, Ricardo M.; El-Kenawy, Ahmed M.; Eddenjal, Ali; Turkes, Murat; Koutroulis, Aristeidis; Manara, Veronica; Maugeri, Maurizio; Badi, Wafae; Mathbout, Shifa; Bertalanic, Renato; Bocheva, Lilia; Dabanli, Ismail; Dumitrescu, Alexandru; Dubuisson, Brigitte; Sahabi-Abed, Salah; Abdulla, Fayez; Fayad, Abbas; Hodzic, Sabina; Ivanov, Mirjana; Radevski, Ivan; Pena-Angulo, Dhais; Lorenzo-Lacruz, Jorge; Dominguez-Castro, Fernando; Gimeno-Sotelo, Luis; Garcia-Herrera, Ricardo; Franquesa, Magi; Halifa-Marin, Amar; Adell-Michavila, Maria; Noguera, Ivan; Barriopedro, David; Garrido-Perez, Jose M.; Azorin-Molina, Cesar; Andres-Martin, Miguel; Gimeno, Luis; Nieto, Raquel; Llasat, Maria Carmen; Markonis, Yannis; Selmi, Rabeb; Ben Rached, Soumaya; Radovanovic, Slavica; Soubeyroux, Jean-Michel; Ribes, Aurelien; Saidi, Mohamed Elmehdi; Bataineh, Siham; El Khalki, El Mahdi; Robaa, Sayed; Boucetta, Amina; Alsafadi, Karam; Mamassis, Nikos; Mohammed, Safwan; Fernandez-Duque, Beatriz; Cheval, Sorin; Moutia, Sara; Stevkov, Aleksandra; Stevkova, Silvana; Luna, M. Yolanda; Potopova, Vera
作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto Pirenaico de Ecologia (IPE); University of Zaragoza; Consejo Superior de Investigaciones Cientificas (CSIC); Universite de Montpellier; Institut de Recherche pour le Developpement (IRD); University of Zaragoza; Consejo Superior de Investigaciones Cientificas (CSIC); Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze dell'Atmosfera e del Clima (ISAC-CNR); University of Salento; Universidade de Lisboa; Egyptian Knowledge Bank (EKB); Mansoura University; Bogazici University; Technical University of Crete; University of Milan; European University Cyprus; University of Barcelona; Istanbul Technical University; Meteo France; Jordan University of Science & Technology; University of Saskatchewan; Saints Cyril & Methodius University of Skopje; Universidad de La Rioja; Universidade de Lisboa; Universidade de Lisboa; Universidade de Vigo; Complutense University of Madrid; Complutense University of Madrid; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UCM - Instituto de Geociencias (IGEO); UK Centre for Ecology & Hydrology (UKCEH); Consejo Superior de Investigaciones Cientificas (CSIC); University of Valencia; CSIC-GV-UV - Centro de Investigaciones sobre Desertificacion (CIDE); Universidade de Vigo; Consejo Superior de Investigaciones Cientificas (CSIC); University of Barcelona; Czech University of Life Sciences Prague; Meteo France; Universite de Toulouse; Centre National de la Recherche Scientifique (CNRS); Cadi Ayyad University of Marrakech; Mohammed VI Polytechnic University; Egyptian Knowledge Bank (EKB); Cairo University; Xiamen University; National Technical University of Athens; University of Debrecen; Agencia Estatal de Meteorologia (AEMET); Czech University of Life Sciences Prague; Czech Academy of Sciences; Global Change Research Centre of the Czech Academy of Sciences
摘要：State-of-the-art climate models project a substantial decline in precipitation for the Mediterranean region in the future1. Supporting this notion, several studies based on observed precipitation data spanning recent decades have suggested a decrease in Mediterranean precipitation2, 3-4, with some attributing a large fraction of this change to anthropogenic influences3,5. Conversely, certain researchers have underlined that Mediterranean precipitation exhibits considerable spatiotemporal varia...
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作者：Cao, Qing; Ammerman, Aaron; Saimi, Mierxiati; Lin, Zongtao; Shen, Guomin; Chen, Huaping; Sun, Jie; Chai, Mengqi; Liu, Shixuan; Hsu, Fong-Fu; Krezel, Andrzej M.; Gross, Michael L.; Xu, Jinbin; Garcia, Benjamin A.; Liu, Bin; Li, Weikai
作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); University of Minnesota System; Harbin Medical University
摘要：The gamma-carboxylation of glutamate residues enables Ca2+-mediated membrane assembly of protein complexes that support broad physiological functions, including haemostasis, calcium homeostasis, immune response and endocrine regulation1, 2, 3-4. Modulating gamma-carboxylation levels provides prevalent treatments for haemorrhagic and thromboembolic diseases5. This unique post-translational modification requires vitamin K hydroquinone (KH2) to drive highly demanding reactions6 catalysed by the m...
