2025

最新文章

• Evolutionary flexibility to gain or lose tooth complexity sparks fish diversification AI翻译
  作者：Ngoepe, Nare
  作者单位：University of Copenhagen
• Clonal driver neoantigen loss under EGFR TKI and immune selection pressures AI翻译
  作者：Al Bakir, Maise; Reading, James L.; Gamble, Samuel; Rosenthal, Rachel; Uddin, Imran; Rowan, Andrew; Przewrocka, Joanna; Rogers, Amber; Wong, Yien Ning Sophia; Bentzen, Amalie K.; Veeriah, Selvaraju; Ward, Sophia; Garnett, Aaron T.; Kalavakur, Paula; Martinez-Ruiz, Carlos; Puttick, Clare; Huebner, Ariana; Cook, Daniel E.; Moore, David A.; Abbosh, Chris; Hiley, Crispin T.; Naceur-Lombardelli, Cristina; Watkins, Thomas B. K.; Petkovic, Marina; Schwarz, Roland F.; Galvez-Cancino, Felipe; Litchfield, Kevin; Meldgaard, Peter; Sorensen, Boe Sandahl; Madsen, Line Bille; Jaeger, Dirk; Forster, Martin D.; Arkenau, Tobias; Domingo-Vila, Clara; Tree, Timothy I. M.; Kadivar, Mohammad; Hadrup, Sine Reker; Chain, Benny; Quezada, Sergio A.; McGranahan, Nicholas; Swanton, Charles
  作者单位：Francis Crick Institute; Cancer Research UK; University of London; University College London; University of London; University College London; University of London; University College London; Francis Crick Institute; University of London; University College London; University College London Hospitals NHS Foundation Trust; University of London; University College London; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Humboldt University of Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; University of Cologne; University of Cologne; University of Oxford; Aarhus University; Aarhus University; Aarhus University; Ruprecht Karls University Heidelberg; University of London; University College London; University of London; University College London
  摘要：Neoantigen vaccines are under investigation for various cancers, including epidermal growth factor receptor (EGFR)-driven lung cancers1,2. We tracked the phylogenetic history of an EGFR mutant lung cancer treated with erlotinib, osimertinib, radiotherapy and a personalized neopeptide vaccine (NPV) targeting ten somatic mutations, including EGFR exon 19 deletion (ex19del). The ex19del mutation was clonal, but is likely to have appeared after a whole-genome doubling (WGD) event. Following osimer...
• Why is my cello howling? AI翻译
  作者：Wiemann, Jasmina
• GABAergic neuron-to-glioma synapses in diffuse midline gliomas AI翻译
  作者：Barron, Tara; Yalcin, Belgin; Su, Minhui; Byun, Youkyeong Gloria; Gavish, Avishai; Shamardani, Kiarash; Xu, Haojun; Ni, Lijun; Soni, Neeraj; Mehta, Vilina; Maleki Jahan, Samin; Kim, Yoon Seok; Taylor, Kathryn R.; Keough, Michael B.; Quezada, Michael A.; Geraghty, Anna C.; Mancusi, Rebecca; Vo, Linh Thuy; Castaneda, Enrique Herrera; Woo, Pamelyn J.; Petritsch, Claudia K.; Vogel, Hannes; Kaila, Kai; Monje, Michelle
  作者单位：Stanford University; Howard Hughes Medical Institute; Stanford University; Stanford University; Stanford University; University of Helsinki; University of Helsinki
  摘要：High-grade gliomas (HGGs) are the leading cause of brain cancer-related death. HGGs include clinically, anatomically and molecularly distinct subtypes that stratify into diffuse midline gliomas (DMGs), such as H3K27M-altered diffuse intrinsic pontine glioma, and hemispheric HGGs, such as IDH wild-type glioblastoma. Neuronal activity drives glioma progression through paracrine signalling1,2 and neuron-to-glioma synapses3, 4, 5-6. Glutamatergic AMPA receptor-dependent synapses between neurons an...
• AI is transforming peer review - and many scientists are worried AI翻译
  作者：Naddaf, Miryam
• What CERN does next matters for science and for international cooperation AI翻译
  作者：[Anonymous]
• Fasting for weight loss is all the rage: what are the health benefits? AI翻译
  作者：Fleming, Nic
• NIH has cut one mRNA-vaccine grant. Will more follow? AI翻译
  作者：Kozlov, Max
• Mechanism for local attenuation of DNA replication at double-strand breaks AI翻译
  作者：Sebastian, Robin; Sun, Eric G.; Fedkenheuer, Michael; Fu, Haiqing; Jung, Seolkyoung; Thakur, Bhushan L.; Redon, Christophe E.; Pegoraro, Gianluca; Tran, Andy D.; Gross, Jacob M.; Mosavarpour, Sara; Kusi, Nana Afua; Ray, Anagh; Dhall, Anjali; Pongor, Lorinc S.; Casellas, Rafael; Aladjem, Mirit I.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS); National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Cornell University; Weill Cornell Medicine; Rockefeller University; Memorial Sloan Kettering Cancer Center; University of Texas System; UTMD Anderson Cancer Center
  摘要：DNA double-strand breaks (DSBs) disrupt the continuity of the genome, with consequences for malignant transformation. Massive DNA damage can elicit a cellular checkpoint response that prevents cell proliferation1,2. However, how highly aggressive cancer cells, which can tolerate widespread DNA damage, respond to DSBs alongside continuous chromosome duplication is unknown. Here we show that DSBs induce a local genome maintenance mechanism that inhibits replication initiation in DSB-containing t...
• Food-industry waste finds a second life as bioplastic AI翻译
  作者：[Anonymous]