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作者：Castelvecchi, Davide
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作者：Chawla, Dalmeet Singh
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作者：Kuznetsov, Nikolai; Nardi, Alberto; Riemensberger, Johann; Davydova, Alisa; Churaev, Mikhail; Seidler, Paul; Kippenberg, Tobias J.
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Norwegian University of Science & Technology (NTNU)
摘要：Optical amplification, crucial for modern communication, primarily relies on erbium-doped fibre amplifiers (EDFAs)1,2. Yet, EDFAs only cover a portion of the low-loss spectrum of optical fibres. This has motivated the development of amplifiers operating beyond the erbium gain window. Pioneering work on optical parametric amplifiers (OPAs)3,4 using intrinsic third-order optical nonlinearity has led to demonstrations of increased channel capacity. OPAs offer high gain, can reach the 3-dB quantum...
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作者：Battin, Tom J.; van Wijngaarden, Albert; Sattler, Birgit; Anesio, Alexandre M.; Cook, Joseph; Huss, Matthias; Edwards, Arwyn
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Cambridge; University of Innsbruck; Aarhus University; Aarhus University; Swiss Federal Institutes of Technology Domain; ETH Zurich; Aberystwyth University
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作者：Mallapaty, Smriti
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作者：Nowogrodzki, Julian
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作者：Proctor, Diana M.; Sansom, Sarah E.; Deming, Clay; Conlan, Sean; Blaustein, Ryan A.; Atkins, Thomas K.; NISC Comparative Sequencing Program, Jim; Mullikin, Jim; Thomas, Jim; Young, Alice; Bouffard, Gerry; Barnabas, Betty; Brooks, Shelise; Han, Joel; Buchter, Chloe; Ho, Shi-ling; Crawford, Juyun; Legaspi, Richelle; Maduro, Quino; Marfani, Holly; Montemayor, Casandra; Riebow, Nancy; Schandler, Karen; Schmidt, Brian; Sison, Christina; Stantripop, Mal; Black, Sean; Dekhtyar, Mila; Masiello, Cathy; McDowell, Jenny; Park, Morgan; Thomas, Pam; Vemulapalli, Meg; Dangana, Thelma; Fukuda, Christine; Thotapalli, Lahari; Kong, Heidi H.; Lin, Michael Y.; Hayden, Mary K.; Segre, Julia A.
作者单位：National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); Rush University; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS); National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); University of Texas System; University of Texas Health Science Center Houston; University System of Maryland; University of Maryland College Park; Princeton University
摘要：Antimicrobial resistance is a public health threat associated with increased morbidity, mortality and financial burden in nursing homes and other healthcare settings1. Residents of nursing homes are at increased risk of pathogen colonization and infection owing to antimicrobial-resistant bacteria and fungi. Nursing homes act as reservoirs, amplifiers and disseminators of antimicrobial resistance in healthcare networks and across geographical regions2. Here we investigate the genomic epidemiolo...
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作者：Hu, Haidai; Popp, Philipp F.; Hughes, Thomas C. D.; Roa-Eguiara, Aritz; Rutbeek, Nicole R.; Martin, Freddie J. O.; Hendriks, Ivo Alexander; Payne, Leighton J.; Yan, Yumeng; Humolli, Dorentina; Klein-Sousa, Victor; Songailiene, Inga; Wang, Yong; Nielsen, Michael Lund; Berry, Richard M.; Harms, Alexander; Erhardt, Marc; Jackson, Simon A.; Taylor, Nicholas M. I.
作者单位：University of Copenhagen; Humboldt University of Berlin; University of Otago; University of Copenhagen; Swiss Federal Institutes of Technology Domain; ETH Zurich; Vilnius University; Zhejiang University; University of Oxford
摘要：Zorya is a recently identified and widely distributed bacterial immune system that protects bacteria from viral (phage) infections. Three Zorya subtypes have been identified, each containing predicted membrane-embedded ZorA-ZorB (ZorAB) complexes paired with soluble subunits that differ among Zorya subtypes, notably ZorC and ZorD in type I Zorya systems1,2. Here we investigate the molecular basis of Zorya defence using cryo-electron microscopy, mutagenesis, fluorescence microscopy, proteomics ...
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作者：Bolakhe, Saugat
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作者：Shaw, Tiffany A.; Stevens, Bjorn
作者单位：University of Chicago; Max Planck Society
摘要：As Earth warms, regional climate signals are accumulating. Some signals, for example, land warming more than the ocean and the Arctic warming the most, were expected and successfully predicted. Underlying this success was the application of physical laws under the assumption that large and small spatial scales are well separated. This established what we call the standard approach, climate science's dominant paradigm. With additional warming, however, discrepancies between real-world signals a...
