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作者：Bod, Lloyd; Kye, Yoon-Chul; Shi, Jingwen; Triglia, Elena Torlai; Schnell, Alexandra; Fessler, Johannes; Ostrowski, Stephen M.; Von-Franque, Max Y.; Kuchroo, Juhi R.; Barilla, Rocky M.; Zaghouani, Sarah; Christian, Elena; Delorey, Toni Marie; Mohib, Kanishka; Xiao, Sheng; Slingerland, Nadine; Giuliano, Christopher J.; Ashenberg, Orr; Li, Zhaorong; Rothstein, David M.; Fisher, David E.; Rozenblatt-Rosen, Orit; Sharpe, Arlene H.; Quintana, Francisco J.; Apetoh, Lionel; Regev, Aviv; Kuchroo, Vijay K.
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作者：Zhang, Hefei; Li, Xuhang; Tseyang, L. Tenzin; Giese, Gabrielle E.; Wang, Hui; Yao, Bo; Zhang, Jingyan; Neve, Rachel L.; Shank, Elizabeth A.; Spinelli, Jessica B.; Yilmaz, L. Safak; Walhout, Albertha J. M.
作者单位：University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; University of Massachusetts System; University of Massachusetts Worcester; UMass Chan Medical School; Fudan University
摘要：Metabolic flux, or the rate of metabolic reactions, is one of the most fundamental metrics describing the status of metabolism in living organisms. However, measuring fluxes across the entire metabolic network remains nearly impossible, especially in multicellular organisms. Computational methods based on flux balance analysis have been used with genome-scale metabolic network models to predict network-level flux wiring1, 2, 3, 4, 5-6. However, such approaches have limited power because of the...
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作者：Hakim, Sara; Jain, Aakanksha; Adamson, Stuart S.; Petrova, Veselina; Indajang, Jonathan; Kim, Hyoung Woo; Kawaguchi, Riki; Wang, Qing; Duran, Elif S.; Nelson, Drew; Greene, Caitlin A.; Rasmussen, Jenae; Woolf, Clifford J.
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles
摘要：Peripheral neuropathy is a common complication of type 2 diabetes, which is strongly associated with obesity1, causing sensory loss and, in some patients, neuropathic pain2,3. Although the onset and progression of diabetic peripheral neuropathy is linked with dyslipidaemia and hyperglycaemia4, the contribution of inflammation to peripheral neuropathy pathogenesis has not been investigated. Here we used a high-fat, high-fructose diet (HFHFD), which induces obesity and prediabetic metabolic chan...
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作者：Sun, Weinan; Winnubst, Johan; Natrajan, Maanasa; Lai, Chongxi; Kajikawa, Koichiro; Bast, Arco; Michaelos, Michalis; Gattoni, Rachel; Stringer, Carsen; Flickinger, Daniel; Fitzgerald, James E.; Spruston, Nelson
作者单位：Howard Hughes Medical Institute; Cornell University; Johns Hopkins University; Northwestern University
摘要：Cognitive maps confer animals with flexible intelligence by representing spatial, temporal and abstract relationships that can be used to shape thought, planning and behaviour. Cognitive maps have been observed in the hippocampus1, but their algorithmic form and learning mechanisms remain obscure. Here we used large-scale, longitudinal two-photon calcium imaging to record activity from thousands of neurons in the CA1 region of the hippocampus while mice learned to efficiently collect rewards f...
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作者：Allam, Zaheer; Cheshmehzangi, Ali
作者单位：University of Technology Sydney; University of Queensland
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作者：Pazos, Sebastian; Zhu, Kaichen; Villena, Marco A.; Alharbi, Osamah; Zheng, Wenwen; Shen, Yaqing; Yuan, Yue; Ping, Yue; Lanza, Mario
作者单位：King Abdullah University of Science & Technology; National University of Singapore; National University of Singapore; Institute for Functional Intelligent Materials (I-FIM); National University of Singapore
摘要：Hardware implementations of artificial neural networks (ANNs)-the most advanced of which are made of millions of electronic neurons interconnected by hundreds of millions of electronic synapses-have achieved higher energy efficiency than classical computers in some small-scale data-intensive computing tasks1. State-of-the-art neuromorphic computers, such as Intel's Loihi2 or IBM's NorthPole3, implement ANNs using bio-inspired neuron- and synapse-mimicking circuits made of complementary metal-o...
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作者：Kamal, Nadia; Spannagl, Manuel
作者单位：Technical University of Munich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Murdoch University
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作者：[Anonymous]
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作者：Dannenberg, Matthew P.; Wise, Erika K.
作者单位：University of Iowa; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
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作者：Shi, Lixue; Lacour, R. Allen; Qian, Naixin; Heindel, Joseph P.; Lang, Xiaoqi; Zhao, Ruoqi; Head-Gordon, Teresa; Min, Wei
作者单位：Columbia University; University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley
摘要：Interfacial water exhibits rich and complex behaviour1, playing an important part in chemistry, biology, geology and engineering. However, there is still much debate on the fundamental properties of water at hydrophobic interfaces, such as orientational ordering, the concentration of hydronium and hydroxide, improper hydrogen bonds and the presence of large electric fields2, 3, 4-5. This controversy arises from the challenges in measuring interfacial systems, even with the most advanced experi...
