2025

最新文章

• Systems-level design principles of metabolic rewiring in an animal AI翻译
  作者：Li, Xuhang; Zhang, Hefei; Hodder, Thomas; Wang, Wen; Myers, Chad L.; Yilmaz, L. Safak; Walhout, Albertha J. M.
  作者单位：University of Massachusetts System; University of Massachusetts Worcester; UMass Chan Medical School; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
  摘要：The regulation of metabolism is vital to any organism and can be achieved by transcriptionally activating or repressing metabolic genes1, 2-3. Although many examples of transcriptional metabolic rewiring have been reported4, a systems-level study of how metabolism is rewired in response to metabolic perturbations is lacking in any animal. Here we apply Worm Perturb-Seq (WPS)-a high-throughput method combining whole-animal RNA-interference and RNA-sequencing5-to around 900 metabolic genes in th...
• New antibiotic that kills drug-resistant bacteria discovered in technician's garden AI翻译
  作者：Mallapaty, Smriti
• Photoinduced copper-catalysed deracemization of alkyl halides AI翻译
  作者：Zhong, Feng; Li, Renhe; Mai, Binh Khanh; Liu, Peng; Fu, Gregory C.
  作者单位：California Institute of Technology; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：Deracemization is an emerging strategy for generating enantioenriched compounds wherein the two enantiomers of a readily available racemic starting material are transformed into a single enantiomer, typically through the action of a light-induced catalyst(1,2). Excellent proof of principle for this potentially powerful approach to asymmetric catalysis has been described(3, 4, 5, 6, 7-8); nevertheless, substantial challenges have not yet been addressed, including the exploitation of carbon-hete...
• Endogenous DNA damage at sites of terminated transcripts AI翻译
  作者：Liu, Jingjing; Perren, Jullian O.; Rogers, Cody M.; Nimer, Sadeieh; Wen, Alice X.; Halliday, Jennifer A.; Fitzgerald, Devon M.; Mei, Qian; Nehring, Ralf B.; Crum, Mary; Kozmin, Stanislav G.; Xia, Jun; Cooke, Matthew B.; Zhai, Yin; Bates, David; Li, Lei; Hastings, P. J.; Artsimovitch, Irina; Herman, Christophe; Sung, Patrick M.; Miller, Kyle M.; Rosenberg, Susan M.
  作者单位：Baylor College of Medicine; Baylor College of Medicine; University of Texas System; University of Texas Austin; University of Texas System; University of Texas at San Antonio; Baylor College of Medicine; Baylor College of Medicine; University of Texas System; UTMD Anderson Cancer Center; University System of Ohio; Ohio State University; Emory University
  摘要：DNA damage promotes mutations that fuel cancer, ageing and neurodegenerative diseases1, 2-3, but surprisingly, the causes and types of damage remain largely unknown. There are three identified mechanisms that damage DNA during transcription: collision of RNA polymerase (RNAP) with the DNA-replication machinery head-on and co-directionally4, 5-6, and R-loop-induced DNA breakage7, 8, 9-10. Here we identify novel DNA damage reaction intermediates11,12 and uncover a fourth transcription-related so...
• Ancient genomes reveal a deep history of Treponema pallidum in the Americas AI翻译
  作者：Barquera, Rodrigo; Sitter, T. Lesley; Kirkpatrick, Casey L.; Ramirez, Dario A.; Kocher, Arthur; Spyrou, Maria A.; Couoh, Lourdes R.; Talavera-Gonzalez, Jorge A.; Castro, Mario; von Hunnius, Tanya; Guevara, Evelyn K.; Hamilton, W. Derek; Roberts, Patrick; Scott, Erin; Fabra, Mariana; Da Pena, Gabriela V.; Pacheco, Aryel; Rodriguez, Monica; Aspillaga, Eugenio; Tiliakou, Anthi; Nelson, Elizabeth A.; Giffin, Karen L.; Bianco, Raffaela A.; Rohrlach, Adam B.; Martinez, Maria de los Angeles Garcia; Solis, Fabiola A. Ballesteros; Sajantila, Antti; Saunders, Shelley R.; Nores, Rodrigo; Herbig, Alexander; Krause, Johannes; Bos, Kirsten I.
  作者单位：Max Planck Society; Western University (University of Western Ontario); National University of Cordoba; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); National University of Cordoba; Eberhard Karls University of Tubingen; Universidad del Desarrollo; Clinica Alemana; McMaster University; University of Helsinki; Max Planck Society; Max Planck Society; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University Nacional Cuyo Mendoza; Durham University; Universidad de Chile; University of Adelaide; University of Adelaide; Simon Fraser University; Southern Methodist University
  摘要：Human treponemal infections are caused by a family of closely related Treponema pallidum that give rise to the diseases yaws, bejel, pinta and, most notably, syphilis1. Debates on a common origin for these pathogens and the history of syphilis itself have weighed evidence for the 'Columbian hypothesis'2, which argues for an American origin, against that for the 'pre-Columbian hypothesis'3, which argues for the presence of the disease in Eurasia in the Medieval period and possibly earlier. Alth...
• NIH to cut grants for COVID research, documents reveal AI翻译
  作者：Kozlov, Max
• How to get rid of toxic 'forever chemical' pollution AI翻译
  作者：Lim, XiaoZhi
• Designer cannabinoids could be the key to pain relief without adverse effects AI翻译
  作者：Greig, Iain R.; Ross, Ruth A.
  作者单位：University of Aberdeen; University of Toronto
• Deep dive: How I use robots to survey coral reefs AI翻译
  作者：Forrester, Nikki; Galbraith, Gemma
  摘要：Marine ecologist Gemma Galbraith builds remotely operated vehicles and uses them to assess how coral reefs are being affected by climate change.
• How to know whether a conference is right for you AI翻译
  作者：Ro, Christine