2025

最新文章

• Leveraging a phased pangenome for haplotype design of hybrid potato AI翻译
  作者：Cheng, Lin; Wang, Nan; Bao, Zhigui; Zhou, Qian; Guarracino, Andrea; Yang, Yuting; Wang, Pei; Zhang, Zhiyang; Tang, Die; Zhang, Pingxian; Wu, Yaoyao; Zhou, Yao; Zheng, Yi; Hu, Yong; Lian, Qun; Ma, Zhaoxu; Lassois, Ludivine; Zhang, Chunzhi; Lucas, William J.; Garrison, Erik; Stein, Nils; Staedler, Thomas; Zhou, Yongfeng; Huang, Sanwen
  作者单位：Chinese Academy of Agricultural Sciences; Agriculture Genomes Institute at Shenzhen, CAAS; University of Liege; Chinese Academy of Tropical Agricultural Sciences; Sun Yat Sen University; University of Tennessee System; University of Tennessee Health Science Center; Yale University; Nanjing Agricultural University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of California System; University of California Davis; Leibniz Institut fur Pflanzengenetik und Kulturpflanzenforschung; Martin Luther University Halle Wittenberg; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：The tetraploid genome and clonal propagation of the cultivated potato (Solanum tuberosum L.)1,2 dictate a slow, non-accumulative breeding mode of the most important tuber crop. Transitioning potato breeding to a seed-propagated hybrid system based on diploid inbred lines has the potential to greatly accelerate its improvement3. Crucially, the development of inbred lines is impeded by manifold deleterious variants; explaining their nature and finding ways to eliminate them is the current focus ...
• Cells are swapping their mitochondria. What does this mean for our health? AI翻译
  作者：Conroy, Gemma
  摘要：Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.
• Where do proteins go in cells? Next-generation methods map the molecules' hidden lives AI翻译
  作者：Remmel, Ariana
• The somatic mutation landscape of normal gastric epithelium AI翻译
  作者：Coorens, Tim H. H.; Collord, Grace; Jung, Hyungchul; Wang, Yichen; Moore, Luiza; Hooks, Yvette; Mahbubani, Krishnaa; Law, Simon Y. K.; Yan, Helen H. N.; Yuen, Siu Tsan; Saeb-Parsy, Kourosh; Campbell, Peter J.; Martincorena, Inigo; Leung, Suet Yi; Stratton, Michael R.
  作者单位：Wellcome Trust Sanger Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of London; University College London; University College London Hospitals NHS Foundation Trust; University of Cambridge; University of Cambridge; University of Hong Kong; University of Hong Kong; Hong Kong St. Paul's Hospital; University of Cambridge
  摘要：The landscapes of somatic mutation in normal cells inform us about the processes of mutation and selection operative throughout life, providing insight into normal ageing and the earliest stages of cancer development1. Here, by whole-genome sequencing of 238 microdissections2 from 30 individuals, including 18 with gastric cancer, we elucidate the developmental trajectories of normal and malignant gastric epithelium. We find that gastric glands are units of monoclonal cell populations that accr...
• Superpowers want to control critical mineral supplies - local communities need a stronger say AI翻译
  作者：Arezki, Rabah
  作者单位：Centre National de la Recherche Scientifique (CNRS)
• Life-giving oxygen is wafting out of lakes worldwide AI翻译
  作者：[Anonymous]
• Solanum pan-genetics reveals paralogues as contingencies in crop engineering AI翻译
  作者：Benoit, Matthias; Jenike, Katharine M.; Satterlee, James W.; Ramakrishnan, Srividya; Gentile, Iacopo; Hendelman, Anat; Passalacqua, Michael J.; Suresh, Hamsini; Shohat, Hagai; Robitaille, Gina M.; Fitzgerald, Blaine; Alonge, Michael; Wang, Xingang; Santos, Ryan; He, Jia; Ou, Shujun; Golan, Hezi; Green, Yumi; Swartwood, Kerry; Karavolias, Nicholas G.; Sierra, Gina P.; Orejuela, Andres; Roda, Federico; Goodwin, Sara; Mccombie, W. Richard; Kizito, Elizabeth B.; Gagnon, Edeline; Knapp, Sandra; Saerkinen, Tiina E.; Frary, Amy; Gillis, Jesse; Van Eck, Joyce; Schatz, Michael C.; Lippman, Zachary B.
  作者单位：Cold Spring Harbor Laboratory; Howard Hughes Medical Institute; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Cold Spring Harbor Laboratory; Cold Spring Harbor Laboratory; Cornell University; Boyce Thompson Institute for Plant Research; Universidad Nacional de Colombia; Universidad de Cartagena; University of Guelph; Natural History Museum London; Mount Holyoke College; University of Toronto; University of Toronto; Cornell University; Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; INRAE; University System of Ohio; Ohio State University; Technical University of Munich
  摘要：Pan-genomics and genome-editing technologies are revolutionizing breeding of global crops1,2. A transformative opportunity lies in exchanging genotype-to-phenotype knowledge between major crops (that is, those cultivated globally) and indigenous crops (that is, those locally cultivated within a circumscribed area)3, 4-5 to enhance our food system. However, species-specific genetic variants and their interactions with desirable natural or engineered mutations pose barriers to achieving predicta...
• Minerals will shape future geopolitical order AI翻译
  作者：Baranowski, Mariusz; Jabkowski, Piotr; Kammen, Daniel M.
  作者单位：Adam Mickiewicz University; University of California System; University of California Berkeley
• Pregnancy's true toll on the body: huge birth study paints most detailed picture yet AI翻译
  作者：Biever, Celeste
• Style over substance? What birds' mating behaviours reveal about sexual selection AI翻译
  作者：Coulson, Tim
  作者单位：University of Oxford