2025

最新文章

• Genome-coverage single-cell histone modifications for embryo lineage tracing AI翻译
  作者：Liu, Min; Yue, Yanzhu; Chen, Xubin; Xian, Kexin; Dong, Chao; Shi, Ming; Xiong, Haiqing; Tian, Kang; Li, Yuzhe; Zhang, Qiangfeng Cliff; He, Aibin
  作者单位：Peking University; Peking University; Peking University; Jilin University; Chinese Academy of Medical Sciences - Peking Union Medical College; Institute of Hematology & Blood Diseases Hospital - CAMS; Peking Union Medical College; Tsinghua University; Tsinghua University; Tsinghua University; Peking University; Peking University; Peking University
  摘要：Substantial epigenetic resetting during early embryo development from fertilization to blastocyst formation ensures zygotic genome activation and leads to progressive cellular heterogeneities1, 2-3. Mapping single-cell epigenomic profiles of core histone modifications that cover each individual cell is a fundamental goal in developmental biology. Here we develop target chromatin indexing and tagmentation (TACIT), a method that enabled genome-coverage single-cell profiling of seven histone modi...
• Precursors of exhausted T cells are pre-emptively formed in acute infection AI翻译
  作者：Chu, Talyn; Wu, Ming; Hoellbacher, Barbara; de Almeida, Gustavo P.; Wurmser, Christine; Berner, Jacqueline; Donhauser, Lara V.; Gerullis, Ann-Katrin; Lin, Siran; Cepeda-Mayorga, J. Diego; Kilb, Iman I.; Bongers, Lukas; Toppeta, Fabio; Strobl, Philipp; Youngblood, Ben; Schulz, Anna M.; Zippelius, Alfred; Knolle, Percy A.; Heinig, Matthias; Hackstein, Carl-Philipp; Zehn, Dietmar
  作者单位：Technical University of Munich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Technical University of Munich; Technical University of Munich; Technical University of Munich; St Jude Children's Research Hospital; University of Basel; Technical University of Munich
  摘要：T cell exhaustion limits effector T cell function in chronic infection and tumours1,2. The development of these hypofunctional T cells and of their precursors was considered to require stimulatory conditions that are met only after persistent exposure to antigen and inflammation. Here we show, however, that similar T cell populations exist in the early phase of acute infections1,2. At that stage, the early developing TCF1+ precursor population exhibits an unexpected diversity; it includes prec...
• Isoprene nitrates drive new particle formation in Amazon's upper troposphere (vol 636, 124, 2024) AI翻译
  作者：Curtius, Joachim; Heinritzi, Martin; Beck, Lisa J.; Poehlker, Mira L.; Tripathi, Nidhi; Krumm, Bianca E.; Holzbeck, Philip; Nussbaumer, Clara M.; Pardo, Lianet Hernandez; Klimach, Thomas; Barmpounis, Konstantinos; Andersen, Simone T.; Bardakov, Roman; Bohn, Birger; Cecchini, Micael A.; Chaboureau, Jean-Pierre; Dauhut, Thibaut; Dienhart, Dirk; Doerich, Raphael; Edtbauer, Achim; Giez, Andreas; Hartmann, Antonia; Holanda, Bruna A.; Joppe, Philipp; Kaiser, Katharina; Keber, Timo; Klebach, Hannah; Krueger, Ovid O.; Kuerten, Andreas; Mallaun, Christian; Marno, Daniel; Martinez, Monica; Monteiro, Carolina; Nelson, Carolina; Ort, Linda; Raj, Subha S.; Richter, Sarah; Ringsdorf, Akima; Rocha, Fabio; Simon, Mario; Sreekumar, Sreedev; Tsokankunku, Anywhere; Unfer, Gabriela R.; Valenti, Isabella D.; Wang, Nijing; Zahn, Andreas; Zauner-Wieczorek, Marcel; Albrecht, Rachel I.; Andreae, Meinrat O.; Artaxo, Paulo; Crowley, John N.; Fischer, Horst; Harder, Hartwig; Herdies, Dirceu L.; Machado, Luiz A. T.; Poehlker, Christopher; Poeschl, Ulrich; Possner, Anna; Pozzer, Andrea; Schneider, Johannes; Williams, Jonathan; Lelieveld, Jos
• A polyene macrolide targeting phospholipids in the fungal cell membrane AI翻译
  作者：Deng, Qisen; Li, Yinchuan; He, Wenyan; Chen, Tao; Liu, Nan; Ma, Lingman; Qiu, Zhixia; Shang, Zhuo; Wang, Zongqiang
  作者单位：China Pharmaceutical University; China Pharmaceutical University; China Pharmaceutical University; Shandong University
  摘要：The global spread of multidrug-resistant pathogenic fungi presents a serious threat to human health, necessitating the discovery of antifungals with unique modes of action1. However, conventional activity-based screening for previously undescribed antibiotics has been hampered by the high-frequency rediscovery of known compounds and the lack of new antifungal targets2. Here we report the discovery of a polyene antifungal antibiotic, mandimycin, using a phylogeny-guided natural-product discover...
• The unusual genetic inheritance that could change Alzheimer's treatment AI翻译
  作者：Vargas-Parada, Laura
• Understanding bones from the remote wilderness of Wyoming AI翻译
  作者：Lovelace, David; Austin, Alexia
  作者单位：University of Wisconsin System; University of Wisconsin Madison
• Japan's big bet on stem-cell therapies might soon pay off with medical breakthroughs AI翻译
  作者：Mallapaty, Smriti
• Will AI improve your life? Here's what 4,000 researchers think AI翻译
  作者：Schwaller, Fred
• Live-cell super-resolution microscopy reveals how molecules enter and exit the nucleus AI翻译
  作者：Rieger, Bernd; Berrevoets, Enya S.
  作者单位：Delft University of Technology
• An animal source of mpox emerges - and it's a squirrel AI翻译
  作者：Qiu, Jane