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作者：[Anonymous]
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作者：Sau, Abhishek; Schnorrenberg, Sebastian; Huang, Ziqiang; Bandyopadhyay, Debolina; Sharma, Ankith; Guerth, Clara-Marie; Dave, Sandeep; Musser, Siegfried M.
作者单位：Texas A&M University System; Texas A&M University College Station; European Molecular Biology Laboratory (EMBL)
摘要：The nuclear pore complex (NPC) mediates nucleocytoplasmic exchange, catalysing a massive flux of protein and nucleic acid material in both directions1. Distinct trafficking pathways for import and export would be an elegant solution to avoid unproductive collisions and opposing movements. However, the three-dimensional (3D) nanoscale spatiotemporal dynamics of macromolecules traversing the NPC remains challenging to visualize on the timescale of millisecond-scale transport events. Here we used...
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作者：Goetzke, Carl Christoph; Massoud, Mona; Frischbutter, Stefan; Guerra, Gabriela Maria; Ferreira-Gomes, Marta; Heinrich, Frederik; von Stuckrad, Anne Sae Lim; Wisniewski, Sebastian; Licha, Jan Robin; Bondareva, Marina; Ehlers, Lisa; Khaldi-Plassart, Samira; Javouhey, Etienne; Pons, Sylvie; Trouillet-Assant, Sophie; Ozsurekci, Yasemin; Zhang, Yu; Poli, Maria Cecilia; Discepolo, Valentina; Lo Vecchio, Andrea; Sahin, Bengue; Verboom, Murielle; Hallensleben, Michael; Heuhsen, Anja Isabelle; Astudillo, Camila; Espinosa, Yazmin; Vial Cox, Maria Cecilia; Dobbs, Kerry; Delmonte, Ottavia M.; Montealegre Sanchez, Gina A.; Magliocco, Mary; Barron, Karyl; Danielson, Jeffrey; Petrov, Lev; Unterwalder, Nadine; Sawitzki, Birgit; Matz, Mareen; Lehmann, Katrin; Gratopp, Alexander; von Bernuth, Horst; Burkhardt, Lisa-Marie; Wiese, Niklas; Peter, Lena; Schmueck-Henneresse, Michael; Amini, Leila; Maurer, Marcus; Roehmel, Jobst Fridolin; Gewurz, Benjamin E.; Yonker, Lael M.; Witkowski, Mario; Kruglov, Andrey; Mall, Marcus Alexander; Su, Helen C.; Ozen, Seza; Radbruch, Andreas; Belot, Alexandre; Durek, Pawel; Kallinich, Tilmann; Mashreghi, Mir-Farzin
作者单位：Leibniz Association; Deutsches Rheuma-Forschungszentrum (DRFZ); Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; CHU Lyon; CHU Lyon; Institut National de la Sante et de la Recherche Medicale (Inserm); CHU Lyon; CHU Lyon; Institut National de la Sante et de la Recherche Medicale (Inserm); Ecole Normale Superieure de Lyon (ENS de LYON); Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1; Hacettepe University; National Institutes of Health (NIH) - USA; Division of Intramural Research (DIR); Universidad del Desarrollo; University of Naples Federico II; University of Naples Federico II; Hannover Medical School; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Massachusetts Institute of Technology (MIT); Lomonosov Moscow State University; Hacettepe University; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1; Ecole Normale Superieure de Lyon (ENS de LYON)
摘要：In a subset of children and adolescents, SARS-CoV-2 infection induces a severe acute hyperinflammatory shock1 termed multisystem inflammatory syndrome in children (MIS-C) at four to eight weeks after infection. MIS-C is characterized by a specific T cell expansion2 and systemic hyperinflammation3. The pathogenesis of MIS-C remains largely unknown. Here we show that acute MIS-C is characterized by impaired reactivation of virus-reactive memory T cells, which depends on increased serum levels of...
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作者：Carli, Elisa
作者单位：European Space Agency
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作者：Wu, Yitao; Shi, Le; Xu, Lei; Ying, Jiale; Miao, Xiaohe; Hua, Bin; Chen, Zhijie; Sessler, Jonathan L.; Huang, Feihe
作者单位：Zhejiang University; Zhejiang University; Zhejiang Normal University; Nanjing University; Westlake University; Westlake University; Zhejiang University; University of Texas System; University of Texas Austin
摘要：Numerous natural products and drugs contain flexible alkyl chains. The resulting conformational motion can create challenges in obtaining single crystals and thus determining their molecular structures by single-crystal X-ray diffraction (SCXRD)1, 2, 3, 4, 5, 6, 7, 8, 9, 10-11. Here we demonstrate that by using pillar[5]arene-incorporated metal-organic frameworks (MOFs) and taking advantage of pillar[5]arene-alkyl chain host-guest recognition12, 13, 14-15, it is possible to reduce this motion ...
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作者：Kam, Amit; Tsesses, Shai; Ilin, Yigal; Cohen, Kobi; Lumer, Yaakov; Fridman, Lior; Lotan, Stav; Patsyk, Anatoly; Nemirovsky-Levy, Liat; Orenstein, Meir; Segev, Mordechai; Bartal, Guy
作者单位：Technion Israel Institute of Technology; Technion Israel Institute of Technology; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Technion Israel Institute of Technology
摘要：Photons can carry angular momentum, which is conventionally attributed to two constituents-spin angular momentum (SAM), which is an intrinsic property related to the polarization, and orbital angular momentum (OAM), which is related to the photon spatial distribution. In paraxial optics, these two forms of angular momentum are separable(1), such that entanglement can be induced between the SAM and the OAM of a single photon(2,3) or of different photons in a multi-photon state(4). In nanophoton...
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作者：Mcmanus, Daniel T.; Valanparambil, Rajesh M.; Medina, Christopher B.; Scharer, Christopher D.; Mcguire, Donald J.; Sobierajska, Ewelina; Hu, Yinghong; Chang, Daniel Y.; Wieland, Andreas; Lee, Judong; Nasti, Tahseen H.; Hashimoto, Masao; Ross, James L.; Prokhnevska, Nataliya; Cardenas, Maria A.; Gill, Amanda L.; Clark, Elisa C.; Abadie, Kathleen; Kumar, Arjun J.; Kaye, Jonathan; Au-Yeung, Byron B.; Kueh, Hao Yuan; Kissick, Haydn T.; Ahmed, Rafi
作者单位：Emory University; Emory University; Emory University; Harvard University; Harvard Medical School; Adventist Health Services; AdventHealth; Mass General Brigham; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; Icahn School of Medicine at Mount Sinai; University of Washington; University of Washington Seattle; Cedars Sinai Medical Center; Emory University; Emory University
摘要：This study examines the origin and differentiation of stem-like CD8+ T cells that are essential for sustained T cell immunity in chronic viral infections and cancer and also have a key role in PD-1 directed immunotherapy1, 2, 3, 4, 5, 6, 7, 8, 9-10. These PD-1+TCF-1+TOX+ stem-like CD8+ T cells (also known as precursors of exhausted T cells8,9) have a distinct program that enables them to adapt to chronic antigen stimulation. Here, using the mouse model of chronic lymphocytic choriomeningitis v...
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作者：Pearson, Helen; Ledford, Heidi; Hutson, Matthew; Van Noorden, Richard
摘要：An exclusive Nature analysis reveals the 25 highest-cited papers published this century and explores why they are breaking records. By Helen Pearson, Heidi Ledford, Matthew Hutson and Richard Van Noorden
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作者：Zhou, Guangdi; Lv, Wei; Wang, Heng; Nie, Zihao; Chen, Yaqi; Li, Yueying; Huang, Haoliang; Chen, Wei-Qiang; Sun, Yu-Jie; Xue, Qi-Kun; Chen, Zhuoyu
作者单位：Southern University of Science & Technology; Southern University of Science & Technology; Tsinghua University
摘要：The discovery of Ruddlesden-Popper (RP) bilayer nickelate superconductors under high pressure has opened a new chapter in high-transition-temperature superconductivity1, 2, 3, 4, 5, 6, 7-8. However, the high-pressure conditions and presence of impurity phases have hindered comprehensive investigations into their superconducting properties and potential applications. Here we report ambient-pressure superconductivity onset above the McMillan limit (40 K) in RP bilayer nickelate epitaxial thin fi...
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作者：Van Noorden, Richard
