Science

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• ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox AI翻译
  作者：DiGiovanni, Laura F.; Khroud, Prabhsimran K.; Carmichael, Ruth E.; Schrader, Tina A.; Gill, Shivneet K.; Germain, Kyla; Jomphe, Robert Y.; Wiesinger, Christoph; Boutry, Maxime; Kamoshita, Maki; Snider, Daniel; Stubbings, Garret; Hua, Rong; Garber, Noel; Hacker, Christian; Rutenberg, Andrew D.; Melnyk, Roman A.; Berger, Johannes; Schrader, Michael; Raught, Brian; Kim, Peter K.
  作者单位：University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Exeter; University of Toronto; Hospital for Sick Children (SickKids); Medical University of Vienna; University of Osaka; Dalhousie University; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; University of Toronto; Kyung Hee University
  摘要：Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmitochondrial antioxidant mechanisms is less well understood. We found a direct role for peroxisomes in maintaining mitochondrial redox homeostasis through contact-mediated reactive oxygen species (ROS) transfer. We found that ACBD5 and PTPIP51 form a contact between peroxisomes and mitochondria. The ...
• MICROBIOLOGY Microbe with tiny genome may evolve into a virus AI翻译
  作者：Wilcox, Christie
• Introgression dynamics of sex-linked chromosomal inversions shape the Malawi cichlid radiation AI翻译
  作者：Blumer, L. M.; Burskaia, V.; Artiushin, I.; Saha, J.; Garcia, J. Camacho; Jimenez, F. Campuzano; Hooft van der Huysdynen, A.; Elkin, J.; Fischer, B.; Van Houtte, N.; Zhou, C.; Gresham, S.; Malinsky, M.; Linderoth, T.; Sawasawa, W.; Vernaz, G.; Bista, I.; Hickey, A.; Kucka, M.; Louzada, S.; Zatha, R.; Yang, F.; Rusuwa, B.; Santos, M. E.; Chan, Y. F.; Joyce, D. A.; Boehne, A.; Miska, E. A.; Ngochera, M.; Turner, G. F.; Durbin, R.; Svardal, H.
  作者单位：University of Cambridge; University of Antwerp; University of Cambridge; Wellcome Trust Sanger Institute; University of Bern; Michigan State University; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Eberhard Karls University of Tubingen; Max Planck Society; University of Malawi; Shandong University of Technology; University of Groningen; University of Hull; University of Cambridge; Bangor University; Naturalis Biodiversity Center; University of Basel; University of Cologne; University of Tras-os-Montes & Alto Douro; BIOISI; Universidade de Lisboa
  摘要：Chromosomal inversions can contribute to adaptive speciation by linking coadapted alleles. By querying 1375 genomes of the species-rich Malawi cichlid fish radiation, we discovered five large inversions segregating in the benthic subradiation that each suppress recombination over more than half a chromosome. Two inversions were transferred from deepwater pelagic Diplotaxodon through admixture, whereas the others established early in the deep benthic clade. Introgression of haplotypes from line...
• Aberrant basal cell clonal dynamics shape early lung carcinogenesis AI翻译
  作者：Gomez-Lopez, Sandra; Alhendi, Ahmed S. N.; Przybilla, Moritz J.; Bordeu, Ignacio; Whiteman, Zoe E.; Butler, Timothy; Rouhani, Maral J.; Kalinke, Lukas; Uddin, Imran; Otter, Kate E. J.; Chandrasekharan, Deepak P.; Lebrusant-Fernandez, Marta; Shurr, Abigail Y. L.; Durrenberger, Pascal F.; Moore, David A.; Falzon, Mary; Reading, James L.; Martincorena, Inigo; Simons, Benjamin D.; Campbell, Peter J.; Janes, Sam M.
  作者单位：University of London; University College London; Wellcome Trust Sanger Institute; Universidad de Chile; University of London; University College London; University of London; University College London; University of London; University College London; Cancer Research UK; University of London; University College London; University College London Hospitals NHS Foundation Trust; University of London; University College London; University of Cambridge; University of Cambridge; University of Cambridge; University of Cambridge; University College London Hospitals NHS Foundation Trust; University of London; University College London
  摘要：Preinvasive squamous lung lesions are precursors of lung squamous cell carcinoma (LUSC). The cellular events underlying lesion formation are unknown. Using a carcinogen-induced model of LUSC with no added genetic hits or cell type bias, we found that carcinogen exposure leads to non-neutral competition among basal cells, aberrant clonal expansions, and basal cell mobilization along the airways. Ultimately, preinvasive lesions developed from a few highly mutated clones that dominate most of the...
• Rethinking jaundice A buildup of unconjugated bilirubin may be a protective response to malaria AI翻译
  作者：Kloehn, Joachim; Soldati-Favre, Dominique
  作者单位：University of Geneva
• Gate-driven band modulation hyperdoping for high-performance p-type 2D semiconductor transistors AI翻译
  作者：Zhao, Bei; Zhang, Zucheng; Xu, Junqing; Guo, Dingli; Gu, Tiancheng; He, Guiming; Lu, Ping; He, Kun; Li, Jia; Chen, Zhao; Ren, Quan; Miao, Lin; Lu, Junpeng; Ni, Zhenhua; Duan, Xiangfeng; Duan, Xidong
  作者单位：Hunan University; Southeast University - China; Southeast University - China; Hefei University of Technology; Southeast University - China; University of California System; University of California Los Angeles
  摘要：Tailoring carrier density in atomically thin two-dimensional (2D) semiconductors is challenging because of the inherently limited physical space for incorporating charge dopants. Here, we report that interlayer charge-transfer doping in type III van der Waals heterostructures can be greatly modulated by an external gate to realize a hyperdoping effect. Systematic gated-Hall measurements revealed that the modulated carrier density is about five times that of the gate capacitive charge, achievin...
• Philippine fisheries put food security at risk AI翻译
  作者：Cabral, Reniel B.; Muallil, Richard N.; Mamauag, Samuel S.; Atrigenio, Michael P.
  作者单位：James Cook University; Mindanao State University System; Mindanao State University-TCTO; De La Salle University; University of the Philippines System; University of the Philippines Diliman
• Social impacts of glacier loss AI翻译
  作者：Howe, Cymene; Boyer, Dominic
  作者单位：Rice University; Rice University
• Fixing the US statistical infrastructure AI翻译
  作者：Potok, Nancy; Groshen, Erica L.
  作者单位：George Washington University; Cornell University; W.E. Upjohn Institute for Employment Research
• Actin organizes chromosomes and microtubules to ensure mitotic fidelity in the preimplantation embryo AI翻译
  作者：Hernandez, Blake; Tetlak, Piotr; Domingo-Muelas, Ana; Akizawa, Hiroki; Skory, Robin M.; Ardestani, Goli; Biro, Mate; Liu, Xiaolei; Bissiere, Stephanie; Sakkas, Denny; Plachta, Nicolas
  作者单位：University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Garvan Institute of Medical Research; European Molecular Biology Laboratory (EMBL); University of New South Wales Sydney; EMBL Australia; University of Pennsylvania; Pennsylvania Medicine
  摘要：Following fertilization, the preimplantation embryo undergoes successive rounds of cell division and must accurately propagate the genetic material to ensure successful development. However, early mammalian embryos lack efficient spindle assembly mechanisms, and it remains unclear how error-free chromosome segregation is achieved. In this work, we imaged early mouse embryos and identified a network of nuclear actin cables that organize prophase chromosomes at the nuclear periphery. Following n...