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• Modulation of methyl-coenzyme M reductase expression alters the isotopic composition of microbial methane AI翻译
  作者：Gropp, Jonathan; Bill, Markus; Lloyd, Max K.; Stein, Rebekah A.; Nayak, Dipti D.; Stolper, Daniel A.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of California System; University of California Berkeley
  摘要：The stable isotopic composition of microbial methane varies substantially, and the underlying causes are debated. In this work, we experimentally controlled the abundance of the central enzyme in methanogenesis, methyl-coenzyme M reductase (MCR), in Methanosarcina acetivorans and tested whether its cellular concentration alters methane isotopic compositions. We found that during growth on methanol and acetate, lowering the expression of mcr increases the degree of hydrogen isotope exchange bet...
• Enantioconvergent benzylic C(sp3)-N coupling with a copper-substituted nonheme enzyme AI翻译
  作者：Shen, Xuzhong; Chen, Xiahe; Xiao, Yihang; Brown, Jesse B.; Zhang, James G.; Ji, Xinyuan; Rui, Jinyan; Garcia-Borras, Marc; Rao, Yi; Yang, Yunfang; Huang, Xiongyi
  作者单位：Johns Hopkins University; Zhejiang University of Technology; Utah System of Higher Education; Utah State University; Universitat de Girona; Universitat de Girona
  摘要：Copper-catalyzed radical C(sp3)-N coupling has become a major focus in synthetic catalysis over the past decade. However, achieving this reaction manifold by using enzymes has remained elusive. In this study, we introduce a photobiocatalytic approach for radical benzylic C(sp3)-N coupling using a copper-substituted nonheme enzyme. Using rhodamine B as a photoredox catalyst, we identified a copper-substituted phenylalanine hydroxylase that facilitates enantioconvergent decarboxylative amination...
• The ins and outs of circulating DNA AI翻译
  作者：Tsui, W. H. Adrian; Lo, Y. M. Dennis
  作者单位：Chinese University of Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong
• Leading a lab, and all it entails AI翻译
  作者：Wai, Jonathan
  作者单位：University of Arkansas System; University of Arkansas Fayetteville; University of Arkansas System; University of Arkansas Fayetteville
• US funding freeze threatens biomedical research AI翻译
  作者：Oliver, Guillermo
  作者单位：Northwestern University; Feinberg School of Medicine
• Dead in Banaras: An Ethnography of Funeral Travelling AI翻译
  作者：[Anonymous]
• Dispersed components drive temperature sensing and response in plants (vol 388, pg 1161, 2025) AI翻译
  作者：Yadav, A. Singh
• Unraveling the emergent chorus of the mind: Machine learning reveals how a hidden neural code orchestrates diverse emotion states AI翻译
  作者：Nair, Aditya
  作者单位：California Institute of Technology
• Fruit fly studies mostly defy concerns about irreproducibility AI翻译
  作者：O'Grady, Cathleen
• Compartmentalization reduces conflict in multipartner plant-insect symbioses AI翻译
  作者：Chomicki, Guillaume; Metzler, Dirk; Naikatini, Alivereti; Renner, Susanne S.
  作者单位：Durham University; University of Munich; University of the South Pacific; Washington University (WUSTL)
  摘要：Many symbioses involve one host species having several mutualist partners, yet theory predicts that unrelated symbionts lead to destabilizing conflict through competition for host resources. We combined isotope labeling, computed-tomography three-dimensional models, behavioral field experiments, and mathematical models to show that Squamellaria plant hosts reduce conflict among their multiple ant symbiont species by offering nesting sites (domatia) divided into compartments with separate entra...