Science

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• Expanded utility belt for tackling bat viruses AI翻译
  作者：Zhou, Jie; Yuen, Kwok Yung
  作者单位：University of Hong Kong; University of Hong Kong
• Admixture's impact on Brazilian population evolution and health AI翻译
  作者：Nunes, Kelly; Castro e Silva, Marcos Araujo; Rodrigues, Maira R.; Lemes, Renan Barbosa; Pezo-Valderrama, Patricio; Kimura, Lilian; de Sena, Lucas Schenatto; Krieger, Jose Eduardo; Varela, Margareth Catoia; de Azevedo, Luiz Otavio; Camargo, Luis Marcelo Aranha; Ferreira, Ricardo G. M.; Krieger, Henrique; Bortolini, Maria Catira; Mill, Jose Geraldo; Sacuena, Putira; Guerreiro, Joao F.; de Souza, Celia M. B.; Veronese, Francisco V.; Vianna, Fernanda S. L.; Comas, David; Pereira, Alexandre C.; Pereira, Lygia V.; Hunemeier, Tabita
  作者单位：Universidade de Sao Paulo; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UPF - Institut de Biologia Evolutiva (IBE); Pompeu Fabra University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UPF - Institut de Biologia Evolutiva (IBE); Pompeu Fabra University; Universidade de Sao Paulo; Fundacao Oswaldo Cruz; Fundacao Oswaldo Cruz; Universidade de Sao Paulo; Universidade Federal do Rio Grande do Sul; Universidade Federal do Espirito Santo; Universidade Federal do Para; Hospital de Clinicas de Porto Alegre; Harvard University; Harvard Medical School
  摘要：Brazil, the largest Latin American country, is underrepresented in genomic research despite boasting the world's largest recently admixed population. In this study, we generated 2723 high-coverage whole-genome sequences from the Brazilian population, including urban, rural, and riverine communities representing diverse ethnic backgrounds. We reveal the impressive genomic diversity of Brazilians, identifying >8 million previously unknown variants, including 36,637 predicted deleterious and pote...
• Lab Dog: What Global Science Owes American Beagles AI翻译
  作者：King, Barbara J.
• The cost of health AI翻译
  作者：Monteiro, Lara de Macedo
  作者单位：University of Vermont
• Flowers with bad breath AI翻译
  作者：Caputi, Lorenzo; O'Connor, Sarah E.
  作者单位：Max Planck Society
• Reducing emissions and air pollution from informal brick kilns: Evidence from Bangladesh AI翻译
  作者：Brooks, Nina; Biswas, Debashish; Maithel, Sameer; Miller, Grant; Mahajan, Aprajit; Uddin, M. Rofi; Ahmed, Shoeb; Mahzab, Moogdho; Rahman, Mahbubur; Luby, Stephen P.
  作者单位：Boston University; International Centre for Diarrhoeal Disease Research (ICDDR); Stanford University; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Bangladesh University of Engineering & Technology (BUET); CGIAR; International Food Policy Research Institute (IFPRI); Stanford University; University of Western Australia
  摘要：We present results from a randomized controlled trial in Bangladesh that introduced operational practices to improve energy efficiency and reduce emissions in 276 zigzag brick kilns. Of all intervention kilns, 65% adopted the improved practices. Treatment assignment reduced energy use by 10.5% (P-value <0.001) and decreased CO2 and PM2.5 emissions by 171 and 0.45 metric tons, respectively, per kiln per year. Valuing the CO2 reductions using a social cost of carbon of 185 USD per metric ton, we...
• Enhanced ERK activity extends ketamine's antidepressant effects by augmenting synaptic plasticity AI翻译
  作者：Ma, Z. Zack; Guzikowski, Natalie J.; Kim, Ji-Woon; Kavalali, Ege T.; Monteggia, Lisa M.
  作者单位：Vanderbilt University; Vanderbilt University; Kyung Hee University
  摘要：Repeated ketamine treatment to maintain a rapid antidepressant effect can lead to side effects over time, highlighting an unmet clinical need for sustaining this drug's antidepressant action from a single administration. Ketamine-induced synaptic potentiation at CA3-CA1 synapses has been proposed to be a key synaptic substrate for antidepressant action. Here, we found that ketamine-induced CA3-CA1 synaptic potentiation could be augmented by transiently increasing extracellular signal-regulated...
• WHO and USAID budget cuts hurt the US AI翻译
  作者：Jalali, Mohammad S.
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Massachusetts Institute of Technology (MIT)
• US policies undermine climate change efforts AI翻译
  作者：Wang, Changdong; Yang, Jingli
  作者单位：Nanyang Technological University; Harbin Institute of Technology
• The AI Con: How to Fight Big Tech's Hype and Create the Future We Want AI翻译
  作者：Tagarro, Pablo M.