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作者：Bataille, Clement P.; Hershauer, Samantha; Justin, Wilson; Stelkia, James Aaron; Topkok, Sean Asikluk; Leonard, Beth Ginondidoy; Means, Bill; Koskey, Michael; Kapp, Joshua D.; Landry, Zoe; Fraser, Danielle; Southon, John; Lindroos, Eve E.; Hassler, Auguste; Chauvey, Lorelei; Tressieres, Gaetan; Tonasso-Calviere, Laure; Schiavinato, Stephanie; Seguin-Orlando, Andaine; Perdereau, Aude; Oliveira, Pedro H.; Aury, Jean-Marc; Wincker, Patrick; Kirillova, Irina V.; Vasiliev, Sergey K.; Kusliy, Mariya A.; Graphodatsky, Alexander S.; Tishkin, Alexey A.; Barnes, Ian; Druckenmiller, Pat; Jass, Christopher N.; Macphee, Ross D. E.; Barron-Ortiz, Christina I.; Groves, Pam; Mann, Dan; Froese, Duane G.; Wooller, Matthew; Miller, Joshua H.; Crowley, Brooke; Zazula, Grant; Hall, Elizabeth; Hewitson, Susan; Shapiro, Beth; Orlando, Ludovic
作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; University of Ottawa; Purdue University System; Purdue University; University of California System; University of California Santa Cruz; University of Alaska System; University of Alaska Fairbanks; Alaska Pacific University; University of California System; University of California Santa Cruz; Carleton University; Smithsonian Institution; Smithsonian National Museum of Natural History; University of California System; University of California Irvine; University of Aberdeen; CEA; Universite Paris Saclay; CEA; Universite Paris Saclay; Russian Academy of Sciences; Siberian Branch of the Russian Academy of Sciences; Altai State University; Natural History Museum London; University of Alaska System; University of Alaska Fairbanks; University of Alaska System; University of Alaska Fairbanks; American Museum of Natural History (AMNH); University of Alaska System; University of Alaska Fairbanks; University of Alberta; University of Alaska System; University of Alaska Fairbanks; University System of Ohio; University of Cincinnati; University System of Ohio; University of Cincinnati
摘要：Climate affects habitat, food availability, and the movement and sustainability of all life. In this work, we apply Indigenous and Western scientific methods, including genomics and isotope profiling, on fossils from across Beringia to explore the effect of climate change on horses. We find that Late Pleistocene horses from Alaska and northern Yukon are related to populations from Eurasia and crossed the Bering land bridge multiple times during the last glacial interval. We also find deeply di...
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作者：Wan, Nian-Feng; Woodcock, Ben A.; Scherber, Christoph; Wyckhuys, Kris A. G.; Li, Zhong; Qian, Xuhong
作者单位：East China University of Science & Technology; UK Centre for Ecology & Hydrology (UKCEH); Zoologisches Forschungsmuseum Alexander Koenig (ZFMK); University of Bonn; Chinese Academy of Agricultural Sciences; Institute of Plant Protection, CAAS; University of Queensland; East China Normal University
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作者：Chen, Alex B.; Duque, Marc; Rymbek, Altyn; Dhanasekar, Mahalakshmi; Wang, Vickie M.; Mi, Xuelong; Tocquer, Loeva; Narayan, Sujatha; Legorreta, Emmanuel Marquez; Eddison, Mark; Yu, Guoqiang; Wyart, Claire; Prober, David A.; Engert, Florian; Ahrens, Misha B.
作者单位：Howard Hughes Medical Institute; Harvard University; Harvard University; Harvard Medical School; California Institute of Technology; Assistance Publique Hopitaux Paris (APHP); Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Virginia Polytechnic Institute & State University; Tsinghua University; Allen Institute for Brain Science
摘要：Both neurons and glia communicate through diffusible neuromodulators; however, how neuron-glial interactions in such neuromodulatory networks influence circuit computation and behavior is unclear. During futility-induced behavioral transitions in the larval zebrafish, the neuromodulator norepinephrine (NE) drives fast excitation and delayed inhibition of behavior and circuit activity. We found that astroglial purinergic signaling implements the inhibitory arm of this motif. In larval zebrafish...
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作者：Sorkhabi, Rasoul
作者单位：Utah System of Higher Education; University of Utah
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作者：Xu, Yan; Tian, Lei; Tan, Jinyi; Huang, Weijie; Li, Josh; O'Neil, Nigel; Hirst, Martin; Hieter, Phil; Zhang, Yuelin; Li, Xin
作者单位：Sichuan University; University of British Columbia; University of British Columbia
摘要：Nuclei define eukaryotes, enabling macromolecular compartmentalization and cellular regulation. Each nucleus is believed to contain one or more haploid sets of chromosomes (1N). However, we discovered that haploid cells of the pathogenic fungi Sclerotinia sclerotiorum and Botrytis cinerea distribute their chromosomes such that each of their nuclei contains only a subset of the haploid chromosomes (<= 1/2N). The unusual chromosomal distribution was confirmed by cellular and molecular methods in...
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作者：Dai, Leilei; Ruan, Roger; Lei, Hanwu; Xiao, Rui; Zhang, Huiyan
作者单位：Southeast University - China; University of Minnesota System; University of Minnesota Twin Cities; Washington State University
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作者：Guttenplan, Kevin A.; Maxwell, Isa; Santos, Erin; Borchardt, Luke A.; Manzo, Ernesto; Abalde-Atristain, Leire; Kim, Rachel D.; Freeman, Marc R.
作者单位：Oregon Health & Science University; New York University
摘要：How astrocytes regulate neuronal circuits is a fundamental question in neurobiology. Specifically, how astrocytes respond to different neurotransmitters in vivo and how they affect downstream circuit modulation are questions that remain to be fully elucidated. Here, we report a mechanism in Drosophila by which G protein-coupled adrenergic signaling in astrocytes can control-or gate-their ability to respond to other neurotransmitters. Further, we show that manipulating this pathway potently reg...
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作者：Werkmeister, Thomas; Ehrets, James R.; Wesson, Marie E.; Najafabadi, Danial H.; Watanabe, Kenji; Taniguchi, Takashi; Halperin, Bertrand I.; Yacoby, Amir; Kim, Philip
作者单位：Harvard University; Harvard University; Harvard University; National Institute for Materials Science; National Institute for Materials Science
摘要：The search for anyons, quasiparticles with fractional charge and exotic exchange statistics, has inspired decades of condensed matter research. Quantum Hall interferometers enable direct observation of the anyon braiding phase through discrete interference phase jumps when the number of encircled localized quasiparticles changes. In this study, we observed this braiding phase in both the filling factor 1/3 and 4/3 fractional quantum Hall states by probing three-state random telegraph noise (RT...
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作者：Kim, Hyunjoon; Heo, Seo-Young; Kim, Young-Il; Park, Dongbin; Hwang, Suhee; Lee, Yong-ki; Jang, Hobin; Ahn, Jae-Woo; Ha, Jeongmin; Park, Sujin; Ji, Ho Young; Kim, Semi; Choi, Isaac; Kwon, Woohyun; Kim, Jaemoo; Kim, Kanghee; Gil, Juryeon; Jeong, Boyeong; Lazarte, Josea Carmel D.; Rollon, Rare; Choi, Jeong Ho; Kim, Eun Ha; Jang, Seung-Gyu; Kim, Hye Kwon; Jeon, Bo-Young; Kayali, Ghazi; Webby, Richard J.; Koo, Bon-Kyoung; Choi, Young Ki
作者单位：Institute for Basic Science - Korea (IBS); Sungkyunkwan University (SKKU); Institute for Basic Science - Korea (IBS); Chungbuk National University; Chungbuk National University; Chungbuk National University; Yonsei University; St Jude Children's Research Hospital; Korea Advanced Institute of Science & Technology (KAIST); Pohang University of Science & Technology (POSTECH)
摘要：Bats are important reservoirs of zoonotic pathogens, but suitable model systems for comprehensively exploring host-pathogen interactions and assessing spillover risks remain limited. To address this gap, we developed a collection of bat organoid models spanning five species and four organ types. This multispecies, multiorgan organoid panel showed species- and tissue-specific replication patterns for several viruses, offering robust pathophysiological models for studying respiratory, renal, and...
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作者：Mitchison, Timothy J.; Sullivan, William T.
作者单位：Harvard University; Harvard Medical School; University of California System; University of California Santa Cruz
