Science

最新文章

• Trump slashes studies of online lies-and how to counter them AI翻译
  作者：Kupferschmidt, Kai
• Science's enduring role in climate policy AI翻译
  作者：Yang, Y. Tony
  作者单位：George Washington University
• De novo design of porphyrin-containing proteins as efficient and stereoselective catalysts AI翻译
  作者：Hou, Kaipeng; Huang, Wei; Qi, Miao; Tugwell, Thomas H.; Alturaifi, Turki M.; Chen, Yuda; Zhang, Xingjie; Lu, Lei; Mann, Samuel I.; Liu, Peng; Yang, Yang; DeGrado, William F.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California Santa Barbara; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of California System; University of California Riverside; University of California System; University of California Santa Barbara
  摘要：De novo design of protein catalysts with high efficiency and stereoselectivity provides an attractive approach toward the design of environmentally benign catalysts. Here, we design proteins that incorporate histidine-ligated synthetic porphyrin and heme ligands. Four of 10 designed proteins catalyzed cyclopropanation with an enantiomeric ratio greater than 99:1. A second class of proteins were designed to catalyze a silicon-hydrogen insertion and were optimized by directed evolution in whole ...
• How Trump upended science AI翻译
  作者：Malakoff, David
• Measurements of molecular size and shape on a chip AI翻译
  作者：Zhu, Xin; Bennett, Timothy J. D.; Zouboulis, Konstantin C.; Soulias, Dimitrios; Grzybek, Michal; Benesch, Justin L. P.; El-Sagheer, Afaf H.; Coskun, Uenal; Krishnan, Madhavi
  作者单位：University of Oxford; University of Oxford; Technische Universitat Dresden; Carl Gustav Carus University Hospital; Technische Universitat Dresden; University of Southampton; University of Southampton; Technische Universitat Dresden; Carl Gustav Carus University Hospital; German Center for Diabetes Research (DZD); Max Planck Society
• China's urbanization at a turning point-challenges and opportunities AI翻译
  作者：Bai, Xuemei; Shi, Peijun
  作者单位：Australian National University; Beijing Normal University
• NIH bans future grant sharing with foreign scientists AI翻译
  作者：Cohen, Jon; Wadman, Meredith
• THE GREAT NERVE AI翻译
  作者：Dolgin, Elie
• Shishania is a chancelloriid and not a Cambrian mollusk AI翻译
  作者：Yang, Jie; Li, Wei; Chen, Ai-lin; Du, Kun-sheng; Peng, Xiao; Wang, Yu; Zhang, Xi-guang; Smith, Martin R.
  作者单位：Yunnan University; Yuxi Normal University; Yunnan University; Durham University
  摘要：The Cambrian evolutionary radiation is noted for its profusion of bizarre and unfamiliar body forms, many of which illuminate the early ancestry of major animal groups. The spine-covered fossil Shishania aculeata (Cambrian Stage 4, Yunnan, China) has been interpreted as intermediate between mollusks and their lophotrochozoan ancestors. Our new material challenges this interpretation. We propose taphonomic explanations for apparent molluscan features and instead identify prominent anatomical si...
• Young people's social mobility expectations in an unequal world AI翻译
  作者：Borgonovi, Francesca; Pokropek, Artur
  作者单位：University of London; University College London; Organisation for Economic Co-operation & Development (OECD); Educational Research Institute (IBE)