Science

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• Pancreatic cancer-restricted cryptic antigens are targets for T cell recognition AI翻译
  作者：Ely, Zackery A.; Kulstad, Zachary J.; Gunaydin, Gurcan; Addepalli, Sudarsana; Verzani, Eva K.; Casarrubios, Marta; Clauser, Karl R.; Wang, Xilin; Lippincott, Isabelle E.; Louvet, Cedric; Schmitt, Thomas; Kapner, Kevin S.; Agus, Miles P.; Hennessey, Connor J.; Cleary, James M.; Hadrup, Sine R.; Klaeger, Susan; Su, Jennifer; Jaeger, Alex M.; Wolpin, Brian M.; Raghavan, Srivatsan; Smith, Eric L.; Greenberg, Philip D.; Aguirre, Andrew J.; Abelin, Jennifer G.; Carr, Steven A.; Jacks, Tyler; Freed-Pastor, William A.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Fred Hutchinson Cancer Center; Technical University of Denmark; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Columbia University; Roche Holding; Genentech; Roche Holding USA; H Lee Moffitt Cancer Center & Research Institute
  摘要：Translation of the noncoding genome in cancer can generate cryptic (noncanonical) peptides capable of presentation by human leukocyte antigen class I (HLA-I); however, the cancer specificity and immunogenicity of noncanonical HLA-I-bound peptides (ncHLAp) are incompletely understood. Using high-resolution immunopeptidomics, we discovered that cryptic peptides are abundant in the pancreatic cancer immunopeptidome. Approximately 30% of ncHLAp exhibited cancer-restricted translation, and a substa...
• 'Data manipulations' alleged in study that led to Microsoft's quantum chip AI翻译
  作者：Orrall, Avery
• The next 100 days AI翻译
  作者：Mervis, Jeffrey
• Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis AI翻译
  作者：Lin, Hui; Ma, Chuanshun; Cai, Kui; Guo, Lulu; Wang, Xuemei; Lv, Lin; Zhang, Chao; Lin, Jun; Zhang, Daolai; Ye, Chuan; Wang, Tengwei; Huang, Shenming; Han, Jifei; Zhang, Zihao; Gao, Junyan; Zhang, Mingxiang; Pu, Zhao; Li, Fengyang; Guo, Yongyuan; Zhou, Xiaojun; Qin, Chengxue; Yi, Fan; Yu, Xiao; Kong, Wei; Jiang, Changtao; Sun, Jin-Peng
  作者单位：Shandong University; Shandong University; Peking University; Shandong University; Shandong University; Shandong University; Shandong University; Shandong University; Binzhou Medical University; University of Toronto; Shandong University; Shandong University; Shandong University; Peking University; Peking University
  摘要：Ceramides play a central role in human health and disease, yet their role as systemic signaling molecules remain poorly understood. In this work, we identify formyl peptide receptor 2 (FPR2) as a membrane receptor that specifically binds long-chain ceramides (C14 to C20). In brown and beige adipocytes, C16:0 ceramide binding to FPR2 inhibits thermogenesis through Gi cyclic adenosine monophosphate signaling pathways, an effect that is reversed in the absence of FPR2. We present three cryo-elect...
• Dimensionality reduction simplifies synaptic partner matching in an olfactory circuit AI翻译
  作者：Lyu, Cheng; Li, Zhuoran; Xu, Chuanyun; Wong, Kenneth Kin Lam; Luginbuhl, David J.; Mclaughlin, Colleen N.; Xie, Qijing; Li, Tongchao; Li, Hongjie; Luo, Liqun
  作者单位：Stanford University; Howard Hughes Medical Institute; Stanford University; Stanford University; Stanford University
  摘要：A navigating axon faces complex choices when selecting postsynaptic partners in a three-dimensional (3D) space. In this work, we discovered a principle that can establish the 3D glomerular map of the fly antennal lobe by reducing the higher dimensionality serially to 1D projections. During development, olfactory receptor neuron (ORN) axons first contact their partner projection neuron dendrites on the spherical surface of the antennal lobe, regardless of whether the adult glomeruli lie near th...
• A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite-CerS6-ceramide axis AI翻译
  作者：Zhou, Shuang; Li, Meng; Wang, Pengcheng; Guo, Chenghao; Zhang, Jinxin; Luo, Xi; Fan, Yu-Chen; Chen, En-Qiang; Qi, Xingshun; Chen, Jinjun; Ye, Lechi; Yuan, Hai-Yang; Yin, Wen-Bing; Wang, Kai; Zheng, Ming-Hua; Pang, Yanli; Qiao, Jie; Jiang, Changtao
  作者单位：Peking University; Peking University; Peking University; Shandong University; Sichuan University; Southern Medical University - China; Fudan University; Wenzhou Medical University; Wenzhou Medical University; Chinese Academy of Sciences; Institute of Microbiology, CAS; Peking University
  摘要：The gut microbiota is known to be associated with a variety of human metabolic diseases, including metabolic dysfunction-associated steatohepatitis (MASH). Fungi are increasingly recognized as important members of this community; however, the role of fungal symbionts in metabolic diseases is unknown. We have systematically isolated and characterized gut fungi, identifying Fusarium foetens as an intestinal symbiotic filamentous fungus in mice. F. foetens reverses MASH progression in mouse model...
• Searching for partners AI翻译
  作者：Zhong, Yuwei; Desplan, Claude
  作者单位：New York University
• Tales from the crypt AI翻译
  作者：Curry, Andrew
• Deep-sea mining interests cannot shape research AI翻译
  作者：Losada, Sebastian; Wang, Mengjiao; Santillo, David
  作者单位：Greenpeace; Greenpeace; University of Exeter
• Benefits of onshoring forestry rely on science AI翻译
  作者：Betts, Matthew G.; Franklin, Jerry F.; Bukoski, Jacob J.; Burivalova, Z.; Conklin, Emily E.; DeLuca, Thomas H.; Fitch, Amelia; Himes, Austin; Panwar, Rajat; Sachs, Hannah; Wiebe, R. Alex; Cerullo, Gianluca
  作者单位：Oregon State University; University of Washington; University of Washington Seattle; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; Washington State University; Princeton University