Assisted reproductive technologies at the nexus of fertility treatment and disease prevention

• 成果类型: Review
• 署名作者: Herbert, Mary; Choudhary, Meenakshi; Zander-Fox, Deidre
• 署名单位: Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust; Monash University; Monash IVF; Monash University
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-11516
• DOI: 10.1126/science.adh0073
• 发表日期: 2023-04-13
• 页码: 164-167
• 关键词: preimplantation genetic diagnosis; mitochondrial-dna disorders; transmission; models; pgd

摘要

Assisted reproductive technology (ART) refers to processing gametes in vitro and usually involves in vitro fertilization. Originally developed for the treatment of infertility, culture of human embryos in vitro also provides an opportunity to screen embryos for inherited genetic disorders of the nuclear and mitochondrial genomes. Progress in identifying causative genetic variants has massively increased the scope of preimplantation genetic testing in preventing genetic disorders. However, because ART procedures are not without risk of adverse maternal and child outcomes, careful consideration of the balance of risks and benefits is warranted. Further research on early human development will help to minimize risks while maximizing the benefits of ART.