-
作者：Steinwand, Susan; Horndli, Cornelia Stacher; Ferris, Elliott; Emery, Jared; Gonzalez Murcia, Josue D.; Rodriguez, Adriana Cristina; Spotswood, Riley J.; Chaix, Amandine; Thomas, Alun; Davey, Crystal; Gregg, Christopher
作者单位：Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah
摘要：Cis-regulatory elements (CREs) drive phenotypic diversity, yet how CREs are causally linked to function remains largely unclear. Our study elucidates functions for conserved cis elements associated with the evolution of mammalian hibernation and metabolic flexibility. Genomic analyses revealed topologically associated domains (TADs) enriched for convergent changes in hibernators, including the Fat Mass & Obesity (Fto) locus. In this TAD, we uncovered genetic circuits for metabolic responses an...
-
作者：Willis, Jordan R.; Prabhakaran, Madhu; Muthui, Michelle; Naidoo, Ansuya; Sincomb, Troy; Wu, Weiwei; Cottrell, Christopher A.; Landais, Elise; deCamp, Allan C.; Keshavarzi, Nahid R.; Kalyuzhniy, Oleksandr; Lee, Jeong Hyun; Murungi, Linda M.; Ogonda, Wilfrida A.; Yates, Nicole L.; Corcoran, Martin M.; Phulera, Swastik; Musando, Joel; Tsai, Amanda; Lemire, Gabrielle; Sein, Yiakon; Muteti, Michael; Alamuri, Praveen; Bohl, Jennifer A.; Holman, Drienna; Himansu, Sunny; Leav, Brett; Reuter, Caroline; Lin, Li-An; Ding, Baoyu; He, Chunla; Straus, Walter L.; MacPhee, Kellie J.; Regadas, Isabel; Nyabundi, Diana V.; Chirchir, Ruth; Anzala, Omu; Kimotho, John N.; Kibet, Caleb; Greene, Kelli; Gao, Hongmei; Beatman, Erica; Benson, Kiara; Laddy, Dominick; Brown, David M.; Bronson, Rhianna; Jean-Baptiste, Jalen; Gajjala, Suprabhath; Rikhtegaran-Tehrani, Zahra; Benner, Alison; Ramaswami, Mukundhan; Lu, Danny; Alavi, Nushin; Amirzehni, Sonya; Kubitz, Michael; Tingle, Ryan; Georgeson, Erik; Phelps, Nicole; Adachi, Yumiko; Liguori, Alessia; Flynn, Claudia; McKenney, Katherine; Zhou, Xiaoya; Owuor, D. Collins; Owuor, Sharon A.; Kim, Soo-Young; Duff, Michael; Kim, Ju Yeong; Gibson, Grace; Baboo, Sabyasachi; Diedrich, Jolene; Schiffner, Torben; Shields, Marisa; Matsoso, Mabela; Santos, Jennifer; Syvertsen, Kristen; Kennedy, Allison; Schroeter, Melissa; Vekemans, Johan; Yates III, John R.; Paulson, James C.; Hyrien, Ollivier; Mcdermott, Adrian B.; Maenetje, Pholo; Nyombayire, Julien; Karita, Etienne; Ingabire, Rosine; Edward, Vinodh; Muturi-Kioi, Vincent; Maenza, Janine; Shapiro, Adrienne E.; Mcelrath, M. Juliana; Edupuganti, Srilatha; Taylor, Barbara S.; Diemert, David; Ozorowski, Gabriel; Koup, Richard A.; Montefiori, David; Ward, Andrew B.; Karlsson Hedestam, Gunilla B.; Tomaras, Georgia; Hunt, Devin J.; Muema, Daniel; Sok, Devin; Laufer, Dagna S.; Andrews, Sarah F.; Nduati, Eunice W.; Schief, William R.
作者单位：Scripps Research Institute; International AIDS Vaccine Initiative; Scripps Research Institute; Scripps Research Institute; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Kenya Medical Research Institute; International AIDS Vaccine Initiative; Fred Hutchinson Cancer Center; International AIDS Vaccine Initiative; Duke University; Duke University; Duke University; Karolinska Institutet; Scripps Research Institute; University of Nairobi; Duke University; Sanofi-Aventis; Sanofi USA; Vanderbilt University; University of Kwazulu Natal; University of Texas System; University of Texas at San Antonio; George Washington University; George Washington University
摘要：A leading HIV vaccine strategy requires a priming immunogen to induce broadly neutralizing antibody (bnAb) precursors, followed by a series of heterologous boosters to elicit somatic hypermutation (SHM) and produce bnAbs. In two randomized, open-label phase 1 human clinical trials, IAVI G002 in the United States and IAVI G003 in Rwanda and South Africa (IAVI, International Aids Vaccine Initiative), we evaluated the safety and immunogenicity of mRNA-encoded nanoparticles as priming immunogens (...
-
作者：Sharma, Aashna
作者单位：University of Washington; University of Washington Seattle
-
作者：Stone, Richard
-
作者：Green, F.
-
作者：Di Fraia, Domenico; Marino, Antonio; Lee, Jae Ho; Kelmer Sacramento, Erika; Baumgart, Mario; Bagnoli, Sara; Balla, Till; Schalk, Felix; Kamrad, Stephan; Guan, Rui; Caterino, Cinzia; Giannuzzi, Chiara; Tomaz da Silva, Pedro; Sahu, Amit Kumar; Gut, Hanna; Siano, Giacomo; Tiessen, Max; Terzibasi-Tozzini, Eva; Fornasiero, Eugenio F.; Gagneur, Julien; Englert, Christoph; Patil, Kiran R.; Correia-Melo, Clara; Nedialkova, Danny D.; Frydman, Judith; Cellerino, Alessandro; Ori, Alessandro
作者单位：Leibniz Association; Leibniz Institut fur Alternsforschung - Fritz-Lipmann-Institut (FLI); Stanford University; Scuola Normale Superiore di Pisa; Max Planck Society; University of Cambridge; Technical University of Munich; Stazione Zoologica Anton Dohrn; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; University of Trieste; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Technical University of Munich; Friedrich Schiller University of Jena; Technical University of Munich; Stanford University
摘要：Aging is a major risk factor for neurodegeneration and is characterized by diverse cellular and molecular hallmarks. To understand the origin of these hallmarks, we studied the effects of aging on the transcriptome, translatome, and proteome in the brain of short-lived killifish. We identified a cascade of events in which aberrant translation pausing led to altered abundance of proteins independently of transcriptional regulation. In particular, aging caused increased ribosome stalling and wid...
-
作者：Ferrante, Lucas; Vilani, Rodrigo Machado; Apurina, Waldemiro; Gabriel Mura, Filipe; Satyro, Natalia; Elias de Oliveira, Vanessa; Lui, Lizandro; Losekann, Cristiana; Grin, Eduardo; Luiz Marenco dos Santos, Andre
作者单位：Universidade de Sao Paulo; Universidade Federal de Amazonas; Universidade Federal do Estado do Rio de Janeiro; Universidade Federal de Minas Gerais; Universidade Federal do ABC (UFABC); Universidade Federal do Espirito Santo; Getulio Vargas Foundation; Universidade Federal do Rio Grande do Sul
-
作者：Caniels, Tom G.; Prabhakaran, Madhu; Ozorowski, Gabriel; MacPhee, Kellie J.; Wu, Weiwei; van der Straten, Karlijn; Agrawal, Sashank; Derking, Ronald; Reiss, Emma I. M. M.; Millard, Katrina; Turroja, Martina; Desrosiers, Aimee; Bethony, Jeffrey; Malkin, Elissa; Liesdek, Marinus H.; van der Veen, Annelou; Klouwens, Michelle; Snitselaar, Jonne L.; Bouhuijs, Joey H.; Bronson, Rhianna; Jean-Baptiste, Jalen; Gajjala, Suprabhath; Rikhtegaran Tehrani, Zahra; Benner, Alison; Ramaswami, Mukundhan; Duff, Michael O.; Liu, Yung-Wen; Sato, Alicia H.; Kim, Ju Yeong; Baken, Isabel J. L.; Mendes Silva, Catarina; Bijl, Tom P. L.; van Rijswijk, Jacqueline; Burger, Judith A.; Cupo, Albert; Yasmeen, Anila; Phulera, Swastik; Lee, Wen-Hsin; Randall Jr, Kipchoge N.; Zhang, Shiyu; Corcoran, Martin M.; Regadas, Isabel; Sullivan, Alex C.; Brown, David M.; Bohl, Jennifer A.; Greene, Kelli M.; Gao, Hongmei; Yates, Nicole L.; Sawant, Sheetal; Prins, Jan M.; Kootstra, Neeltje A.; Kaminsky, Stephen M.; Barin, Burc; Rahaman, Farhad; Meller, Margaret; Philiponis, Vince; Laufer, Dagna S.; Lombardo, Angela; Mwoga, Lindsey; Shotorbani, Solmaz; Holman, Drienna; Koup, Richard A.; Klasse, Per Johan; Karlsson Hedestam, Gunilla B.; Tomaras, Georgia D.; van Gils, Marit J.; Montefiori, David C.; Mcdermott, Adrian B.; Hyrien, Ollivier; Moore, John P.; Wilson, Ian A.; Ward, Andrew B.; Diemert, David J.; de Bree, Godelieve J.; Andrews, Sarah F.; Caskey, Marina; Sanders, Rogier W.
作者单位：University of Amsterdam; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Scripps Research Institute; Fred Hutchinson Cancer Center; Rockefeller University; George Washington University; University of Amsterdam; Cornell University; Weill Cornell Medicine; Karolinska Institutet; National Institutes of Health (NIH) - USA; Duke University; University of Amsterdam; Cornell University; Weill Cornell Medicine; International AIDS Vaccine Initiative; Scripps Research Institute
摘要：A protective HIV vaccine will need to induce broadly neutralizing antibodies (bnAbs) in humans, but priming rare bnAb precursor B cells has been challenging. In a double-blinded, placebo-controlled phase 1 human clinical trial, the recombinant, germline-targeting envelope glycoprotein (Env) trimer BG505 SOSIP.v4.1-GT1.1, adjuvanted with AS01B, induced bnAb precursors of the VRC01-class at a high frequency in the majority of vaccine recipients. These bnAb precursors, which target the CD4 recept...
-
作者：Permar, Sallie R.; Wilson, Patrick C.
作者单位：Cornell University; Weill Cornell Medicine
-
作者：Stone, Richard
