Science

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• Evolution of antiviral host defenses against a backdrop of endogenous retroelements AI翻译
  作者：Kassiotis, George; Stoye, Jonathan P.
  作者单位：Francis Crick Institute; Imperial College London
  摘要：Mammalian hosts deploy a multitude of germ line-encoded mechanisms to detect and restrict virus infection. These mechanisms must avoid pathological responses to endogenous retroviruses and other endogenous retrotransposable elements (RTEs)-viruses and viruslike genomic parasites that have invaded the host germ line and are passed down the generations as host genes. Although the location, specificity, and sensitivity of innate pattern recognition receptors and restriction factors are tuned to f...
• Three-dimensional nucleation and growth of deformation twins in magnesium AI翻译
  作者：Lee, Sangwon; Pilipchuk, Michael; Yildirim, Can; Greeley, Duncan; Shi, Qianying; Berman, Tracy D.; Creuziger, Adam; Rust, Evan; Detlefs, Carsten; Sundararaghavan, Veera; Allison, John E.; Bucsek, Ashley
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; European Synchrotron Radiation Facility (ESRF); United States Department of Energy (DOE); Los Alamos National Laboratory; University of Michigan System; University of Michigan; National Institute of Standards & Technology (NIST) - USA
  摘要：At two-thirds the weight of aluminum, magnesium alloys have the potential to reduce the fuel consumption of transportation vehicles. These advancements depend on our ability to optimize the desirable versus undesirable effects of deformation twins, which are three-dimensional (3D) microstructural domains that form under mechanical stresses. Previously only characterized through surface or thin-film measurements, we present 3D in situ characterization of deformation twinning inside an embedded ...
• Hardening nature's toughest teeth AI翻译
  作者：Scheffel, Andre
  作者单位：Universitat Greifswald
• Moire eyes detect the dim AI翻译
  作者：Bandurin, Denis
  作者单位：National University of Singapore
• How a diagnosis altered my path AI翻译
  作者：De Vuyst, Matteo
  作者单位：Ghent University
• Senate panel rejects Trump's plan to slash NIH's budget AI翻译
  作者：Kaiser, Jocelyn
• In Other Journals AI翻译
  作者：Simonti, Corinne; Smith, Jesse
• Improving Alzheimer's disease immunotherapy AI翻译
  作者：Xing, Mengen; Song, Weihong
  作者单位：Wenzhou Medical University; Oujiang Laboratory; Wenzhou Medical University; Wenzhou Medical University
• Quantum technology governance: A standards-first approach AI翻译
  作者：Aboy, Mateo; Gasser, Urs; Cohen, I. Glenn; Kop, Mauritz
  作者单位：University of Cambridge; University of Cambridge; Technical University of Munich; Harvard University; Stanford University
• The membrane skeleton is constitutively remodeled in neurons by calcium signaling AI翻译
  作者：Heller, Evan; Kurup, Naina; Zhuang, Xiaowei
  作者单位：Harvard University; Howard Hughes Medical Institute; Harvard University; Harvard University
  摘要：The membrane skeleton in neurons adopts a periodic lattice structure in which actin filaments, capped by adducin and tropomodulin, form ring-shaped structures connected by spectrin tetramers along neurites. This membrane-associated periodic skeleton (MPS) is important for many neuronal functions. Using live-cell super-resolution imaging, we found that the MPS is surprisingly dynamic, undergoing local disassembly and reformation constitutively in axons. MPS remodeling is driven by calcium signa...