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作者：Haque, Tamara T.; Kaplan, Mark H.
作者单位：Indiana University System; Indiana University Indianapolis; Indiana University System; Indiana University Indianapolis
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作者：Pizzo, Michelle E.; Plowey, Edward D.; Khoury, Nathalie; Kwan, Wanda; Abettan, Jordan; DeVos, Sarah L.; Discenza, Claire B.; Earr, Timothy; Joy, David; Lye-Barthel, Ming; Roche, Elysia; Chan, Darren; Dugas, Jason C.; Gadkar, Kapil; Hamann, Stefan; Meisner, Rene; Sebalusky, Jennifer; Silva Amaral, Ana Claudia; Becerra, Isabel; Chau, Roni; Chow, Johann; Clemens, Allisa J.; Dennis, Mark S.; Duque, Joseph; Fusaro, Laura; Getz, Jennifer A.; Kariolis, Mihalis S.; Kim, Do Jin; Lechtenberg, Kendra J.; Leung, Amy Wing-Sze; Moshkforoush, Arash; Nguyen, Hoang N.; Ojo, Emmanuel S.; Thomsen, Elliot R.; Torres, Vanessa O.; Sanchez, Pascal E.; Shan, Lu; Silverman, Adam P.; Sweeney, Zachary K.; Solanoy, Hilda; Tong, Raymond; Calvert, Meredith E.; Watts, Ryan J.; Thorne, Robert G.; Weinreb, Paul H.; Walsh, Dominic M.; Lewcock, Joseph W.; Bussiere, Thierry; Zuchero, Y. Joy Yu
作者单位：Biogen; University of Minnesota System; University of Minnesota Twin Cities
摘要：Amyloid-related imaging abnormalities (ARIA), side effects of anti-amyloid drugs seen in magnetic resonance imaging of the brain, are a major safety concern in patients with Alzheimer's disease. We developed an antibody transport vehicle (ATV) targeting transferrin receptor (TfR) for brain delivery of anti-amyloid-beta protein (anti-A beta) using asymmetrical Fc mutations (ATVcisLALA) that mitigates TfR-related liabilities and retains effector function when bound to A beta. Administration of A...
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作者：Richard, Benoit; Boll, Rebecca; Banerjee, Sourav; Schaefer, Julia M.; Jurek, Zoltan; Kastirke, Gregor; Fehre, Kilian; Schoeffler, Markus S.; Anders, Nils; Baumann, Thomas M.; Eckart, Sebastian; Erk, Benjamin; De Fanis, Alberto; Doerner, Reinhard; Grundmann, Sven; Grychtol, Patrik; Hofmann, Max; Ilchen, Markus; Kircher, Max; Kubicek, Katharina; Kunitski, Maksim; Li, Xiang; Mazza, Tommaso; Meister, Severin; Melzer, Niklas; Montano, Jacobo; Music, Valerija; Ovcharenko, Yevheniy; Passow, Christopher; Pier, Andreas; Rennhack, Nils; Rist, Jonas; Rivas, Daniel E.; Rolles, Daniel; Schlichting, Ilme; Schmidt, Lothar Ph. H.; Schmidt, Philipp; Trabert, Daniel; Trinter, Florian; Wagner, Rene; Walter, Peter; Ziolkowski, Pawel; Rudenko, Artem; Meyer, Michael; Santra, Robin; Inhester, Ludger; Jahnke, Till
作者单位：Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); University of Hamburg; University of Hamburg; European XFEL; University of Hamburg; Goethe University Frankfurt; Helmholtz Association; GSI Helmholtz-Center for Heavy Ion Research; Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); Kansas State University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Max Planck Society; Universitat Kassel; Universitat Kassel; Max Planck Society; Max Planck Society; Fritz Haber Institute of the Max Planck Society
摘要：Because of the Heisenberg uncertainty principle, the structure of a molecule fluctuates about its mean geometry, even in the ground state. Observing this fundamental quantum effect experimentally-particularly, revealing the collective nature of the structural quantum fluctuations-remains an unmet challenge for complex molecules. In this work, we achieved this for an 11-atom molecule by inducing its Coulomb explosion with an x-ray free-electron laser. We show that the structural fluctuations ma...
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作者：Thorp, H. Holden
作者单位：Columbia University
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作者：Enserink, Martin
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作者：Jaganathan, Kishore; Ersaro, Nicole; Novakovsky, Gherman; Wang, Yuchuan; James, Terena; Schwartzentruber, Jeremy; Fiziev, Petko; Kassam, Irfahan; Cao, Fan; Hawe, Johann; Cavanagh, Henry; Lim, Ashley; Png, Grace; Mcrae, Jeremy; Banerjee, Abhimanyu; Kumar, Arvind; Ulirsch, Jacob; Zhang, Yan; Aguet, Francois; Wainschtein, Pierrick; Sundaram, Laksshman; Salcedo, Adriana; Panagiotopoulou, Sofia Kyriazopoulou; Aghamirzaie, Delasa; Padhi, Evin; Weng, Ziming; Dong, Shan; Smedley, Damian; Caulfield, Mark; O'Donnell-Luria, Anne; Rehm, Heidi L.; Sanders, Stephan J.; Kundaje, Anshul; Montgomery, Stephen B.; Ross, Mark T.; Farh, Kyle Kai-How
作者单位：Illumina; Stanford University; University of California System; University of California San Francisco; University of Oxford; University of London; Queen Mary University London; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Stanford University; Stanford University; Stanford University
摘要：Only a minority of patients with rare genetic diseases are presently diagnosed by exome sequencing, suggesting that additional unrecognized pathogenic variants may reside in noncoding sequence. In this work, we describe PromoterAI, a deep neural network that accurately identifies noncoding promoter variants that dysregulate gene expression. We show that promoter variants with predicted expression-altering consequences produce outlier expression at both the RNA and protein levels in thousands o...
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作者：Diercks, Christian S.; Sondermann, Philipp; Rong, Cynthia; Gillis, Thomas G.; Ban, Yahui; Wang, Celine; Dik, David A.; Schultz, Peter G.
作者单位：Scripps Research Institute
摘要：Systems that perform continuous hypermutation of designated genes without compromising the integrity of the host genome can substantially accelerate the evolution of new or enhanced protein functions. We describe an orthogonal DNA replication system in Escherichia coli based on the controlled expression of the replisome of bacteriophage T7 (T7-ORACLE). The system replicates circular plasmids that enable high transformation efficiencies and seamless integration into standard molecular biology w...
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作者：O'Grady, Cathleen
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作者：Venkatraman, Vijaysree
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作者：Nahrendorf, Matthias; Ginhoux, Florent; Swirski, Filip K.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Wurzburg; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Universite Paris Saclay; UNICANCER; Gustave Roussy; Institut National de la Sante et de la Recherche Medicale (Inserm); Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); Chinese Academy of Sciences; Shanghai Jiao Tong University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
摘要：The immune system's central function is to maintain homeostasis by guarding the organism against dangerous external and internal stressors. Immunity's operational toolbox contains diverse processes, such as phagocytosis, antigen recognition, cell killing, and secretion of cytokines and antibodies. Although immune cells interact with each other, they also communicate with cells typically associated with other organ systems, including the nervous, circulatory, metabolic, musculoskeletal, endocri...
