-
作者：Ting, Pamela Y.; Borikar, Sneha; Kerrigan, John Ryan; Thomsen, Noel M.; Aghania, Eamon; Hinman, Amelia E.; Reyes, Alejandro; Pizzato, Nicolas; Fodor, Barna D.; Wu, Fabian; Belew, Muluken S.; Mao, Xiaohong; Wang, Jian; Chitnis, Shripad; Niu, Wei; Hachey, Amanda; Cobb, Jennifer S.; Savage, Nikolas A.; Burke, Ashley; Paulk, Joshiawa; Dovala, Dustin; Lin, James; Clifton, Matthew C.; Ornelas, Elizabeth; Ma, Xiaolei; Ware, Nathaniel F.; Sanchez, Carina C.; Taraszka, John; Terranova, Remi; Knehr, Judith; Altorfer, Marc; Barnes, S. Whitney; Beckwith, Rohan E. J.; Solomon, Jonathan M.; Dales, Natalie A.; Patterson, Andrew W.; Wagner, Juergen; Bouwmeester, Tewis; Dranoff, Glenn; Stevenson, Susan C.; Bradner, James E.
作者单位：Novartis; Novartis USA; Novartis; Novartis; Novartis USA; Novartis; Novartis USA; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Amgen
摘要：Sickle cell disease (SCD) is a prevalent, life-threatening condition attributable to a heritable mutation in beta-hemoglobin. Therapeutic induction of fetal hemoglobin (HbF) can ameliorate disease complications and has been intently pursued. However, safe and effective small-molecule inducers of HbF remain elusive. We report the discovery of dWIZ-1 and dWIZ-2, molecular glue degraders of the WIZ transcription factor that robustly induce HbF in erythroblasts. Phenotypic screening of a cereblon ...
-
作者：Li, Hongyuan; Xiang, Ziyu; Reddy, Aidan P.; Devakul, Trithep; Sailus, Renee; Banerjee, Rounak; Taniguchi, Takashi; Watanabe, Kenji; Tongay, Sefaattin; Zettl, Alex; Fu, Liang; Crommie, Michael F.; Wang, Feng
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Massachusetts Institute of Technology (MIT); Arizona State University; Arizona State University-Tempe; National Institute for Materials Science; National Institute for Materials Science; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：Semiconductor moire superlattices provide a versatile platform to engineer quantum solids composed of artificial atoms on moire sites. Previous studies have mostly focused on the simplest correlated quantum solid-the Fermi-Hubbard model-in which intra-atom interactions are simplified to a single onsite repulsion energy U. Here we report the experimental observation of Wigner molecular crystals emerging from multielectron artificial atoms in twisted bilayer tungsten disulfide moire superlattice...
-
作者：Weimann, Aaron; Dinan, Adam M.; Ruis, Christopher; Bernut, Audrey; Pont, Stephane; Brown, Karen; Ryan, Judy; Santos, Lucia; Ellison, Louise; Ukor, Emem; Pandurangan, Arun P.; Krokowski, Sina; Blundell, Tom L.; Welch, Martin; Blane, Beth; Judge, Kim; Bousfield, Rachel; Brown, Nicholas; Bryant, Josephine M.; Kukavica-Ibrulj, Irena; Rampioni, Giordano; Leoni, Livia; Harrison, Patrick T.; Peacock, Sharon J.; Thomson, Nicholas R.; Gauthier, Jeff; Fothergill, Jo L.; Levesque, Roger C.; Parkhill, Julian; Floto, R. Andres
作者单位：University of Cambridge; MRC Laboratory Molecular Biology; University of Cambridge; University of Cambridge; University of Cambridge; Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Papworth Hospital; University College Cork; University of Cambridge; University of Cambridge; Wellcome Trust Sanger Institute; Laval University; Italfarmaco; Roma Tre University; IRCCS Santa Lucia; University of London; London School of Hygiene & Tropical Medicine; University of Liverpool
摘要：The major human bacterial pathogen Pseudomonas aeruginosa causes multidrug-resistant infections in people with underlying immunodeficiencies or structural lung diseases such as cystic fibrosis (CF). We show that a few environmental isolates, driven by horizontal gene acquisition, have become dominant epidemic clones that have sequentially emerged and spread through global transmission networks over the past 200 years. These clones demonstrate varying intrinsic propensities for infecting CF or ...
-
作者：Voosen, Paul
摘要：Fears of AI and foreign influence prompt panic among publishers
-
作者：Armstrong, Les; Canaan, Alexa; Knittel, Christopher; Metcalf, Gilbert; Schittekatte, Tim
作者单位：Massachusetts Institute of Technology (MIT); Booz Allen Hamilton Holding Corporation; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
-
作者：Bian, Renji; He, Ri; Pan, Er; Li, Zefen; Cao, Guiming; Meng, Peng; Chen, Jiangang; Liu, Qing; Zhong, Zhicheng; Li, Wenwu; Liu, Fucai
作者单位：University of Electronic Science & Technology of China; University of Electronic Science & Technology of China; Chinese Academy of Sciences; Chinese Academy of Sciences; Ningbo Institute of Materials Technology & Engineering, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Fudan University; Fudan University; University of Electronic Science & Technology of China
摘要：Ferroelectric materials have switchable electrical polarization that is appealing for high-density nonvolatile memories. However, inevitable fatigue hinders practical applications of these materials. Fatigue-free ferroelectric switching could dramatically improve the endurance of such devices. We report a fatigue-free ferroelectric system based on the sliding ferroelectricity of bilayer 3R molybdenum disulfide (3R-MoS2). The memory performance of this ferroelectric device does not show the wak...
-
作者：Ma, Jian-Wen; Zeng, Fu-Rong; Lin, Xin-Cen; Wang, Yan-Qin; Ma, Yi-Heng; Jia, Xu-Xu; Zhang, Jin-Cheng; Liu, Bo-Wen; Wang, Yu-Zhong; Zhao, Hai-Bo
作者单位：Sichuan University
摘要：Passive radiant cooling is a potentially sustainable thermal management strategy amid escalating global climate change. However, petrochemical-derived cooling materials often face efficiency challenges owing to the absorption of sunlight. We present an intrinsic photoluminescent biomass aerogel, which has a visible light reflectance exceeding 100%, that yields a large cooling effect. We discovered that DNA and gelatin aggregation into an ordered layered aerogel achieves a solar-weighted reflec...
-
作者：[Anonymous]
-
作者：Wei, Xin; Chen, Mengjiao; Zhang, Qi; Gong, Junyi; Liu, Jie; Yong, Kaicheng; Wang, Qin; Fan, Jiongjiong; Chen, Suhui; Hua, Hua; Luo, Zhaowei; Zhao, Xiaoyan; Wang, Xuan; Li, Wei; Cong, Jia; Yu, Xiting; Wang, Zhihan; Huang, Ruipeng; Chen, Jiaxin; Zhou, Xiaoyi; Qiu, Jie; Xu, Ping; Murray, Jeremy; Wang, Hai; Xu, Yang; Xu, Chenwu; Xu, Gen; Yang, Jinliang; Han, Bin; Huang, Xuehui
作者单位：Shanghai Normal University; Chinese Academy of Agricultural Sciences; China National Rice Research Institute, CAAS; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; China Agricultural University; Yangzhou University; University of Nebraska System; University of Nebraska Lincoln
摘要：Understanding how numerous quantitative trait loci (QTL) shape phenotypic variation is an important question in genetics. To address this, we established a permanent population of 18,421 (18K) rice lines with reduced population structure. We generated reference-level genome assemblies of the founders and genotyped all 18K-rice lines through whole-genome sequencing. Through high-resolution mapping, 96 high-quality candidate genes contributing to variation in 16 traits were identified, including...
-
作者：Clery, Daniel
