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• Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model AI翻译
  作者：Rasmussen, Martin Kaag; Mollgard, Kjeld; Bork, Peter A. R.; Weikop, Pia; Esmail, Tina; Drici, Lylia; Albrechtsen, Nicolai J. Wewer; Carlsen, Jonathan Frederik; Huynh, Nguyen P. T.; Ghitani, Nima; Mann, Matthias; Goldman, Steven A.; Mori, Yuki; Chesler, Alexander T.; Nedergaard, Maiken
  作者单位：University of Copenhagen; University of Copenhagen; University of Copenhagen; University of Copenhagen; University of Copenhagen; Copenhagen University Hospital; Rigshospitalet; University of Rochester; Max Planck Society; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
  摘要：Classical migraine patients experience aura, which is transient neurological deficits associated with cortical spreading depression (CSD), preceding headache attacks. It is not currently understood how a pathological event in cortex can affect peripheral sensory neurons. In this study, we show that cerebrospinal fluid (CSF) flows into the trigeminal ganglion, establishing nonsynaptic signaling between brain and trigeminal cells. After CSD, similar to 11% of the CSF proteome is altered, with up...
• Dutch universities battle threats AI翻译
  作者：[Anonymous]
• Asian American cancer probed AI翻译
  作者：[Anonymous]
• Exposed wires: A microbial metabolite influences myelination in the brain AI翻译
  作者：Needham, Brittany
  作者单位：Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington
• Lymphocytes as a living drug for cancer AI翻译
  作者：Rosenberg, Steven A.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
• A new path to migraine AI翻译
  作者：Russo, Andrew F.; Iliff, Jeffrey J.
  作者单位：University of Iowa; US Department of Veterans Affairs; Veterans Health Administration (VHA); Iowa City VA Health Care System; US Department of Veterans Affairs; Veterans Health Administration (VHA); Vet Affairs Puget Sound Health Care System; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
  摘要：Migraine pain is believed to result from the activation of pain receptors (nociceptors) after the cortical spreading depression (CSD) that is associated with the aura phase of migraine ( 1 ). Previous studies have demonstrated that preclinical CSD events release small molecules through the cerebrospinal fluid (CSF) that activate and sensitize afferent trigeminal fibers within the meninges ( 2 , 3 ). However, it has been thought that trigeminal ganglia reside outside the blood-brain barrier and...
• An atlas of transcribed enhancers across helper T cell diversity for decoding human diseases AI翻译
  作者：Oguchi, Akiko; Suzuki, Akari; Komatsu, Shuichiro; Yoshitomi, Hiroyuki; Bhagat, Shruti; Son, Raku; Bonnal, Raoul Jean Pierre; Kojima, Shohei; Koido, Masaru; Takeuchi, Kazuhiro; Myouzen, Keiko; Inoue, Gyo; Hirai, Tomoya; Sano, Hiromi; Takegami, Yujiro; Kanemaru, Ai; Yamaguchi, Itaru; Ishikawa, Yuki; Tanaka, Nao; Hirabayashi, Shigeki; Konishi, Riyo; Sekito, Sho; Inoue, Takahiro; Kere, Juha; Takeda, Shunichi; Takaori-Kondo, Akifumi; Endo, Itaru; Kawaoka, Shinpei; Kawaji, Hideya; Ishigaki, Kazuyoshi; Ueno, Hideki; Hayashizaki, Yoshihide; Pagani, Massimiliano; Carninci, Piero; Yanagita, Motoko; Parrish, Nicholas; Terao, Chikashi; Yamamoto, Kazuhiko; Murakawa, Yasuhiro
  作者单位：RIKEN; Kyoto University; Kyoto University; RIKEN; IFOM - FIRC Institute of Molecular Oncology; Kyoto University; RIKEN; University of Tokyo; University of Tokyo; RIKEN; Kyoto University; Yokohama City University; Kyoto University; Kyushu University; Kyoto University; Mie University; Karolinska Institutet; University of Helsinki; Folkhalsan Research Center; Kyoto University; Shenzhen University; Tohoku University; Tokyo Metropolitan Institute of Medical Science; RIKEN; RIKEN; RIKEN; RIKEN; Human Technopole; Shizuoka General Hospital; University of Shizuoka
  摘要：INTRODUCTION: Enhancers are distal cis-regulatory elements that increase the expression of target genes. Active enhancers produce bidirectional enhancer RNAs (eRNAs). Transcription of eRNAs can be used to measure enhancer activity and to delineate enhancer architecture at nucleotide resolution. Profiling of transcribed enhancers in single human cells can provide insights into cell type-specific gene regulation and genetic predisposition to diseases. However, comprehensive maps of eRNAs in cell...
• Interfacial epitaxy of multilayer rhombohedral transition-metal dichalcogenide single crystals AI翻译
  作者：Qin, Biao; Ma, Chaojie; Guo, Quanlin; Li, Xiuzhen; Wei, Wenya; Ma, Chenjun; Wang, Qinghe; Liu, Fang; Zhao, Mengze; Xue, Guodong; Qi, Jiajie; Wu, Muhong; Hong, Hao; Du, Luojun; Zhao, Qing; Gao, Peng; Wang, Xinqiang; Wang, Enge; Zhang, Guangyu; Liu, Can; Liu, Kaihui
  作者单位：Peking University; Renmin University of China; Chinese Academy of Sciences; Chinese Academy of Sciences; Institute of Physics, CAS; South China Normal University; Peking University; Tsinghua University; Collaborative Innovation Center of Quantum Matter; Songshan Lake Materials Laboratory; Peking University; Peking University
  摘要：Rhombohedral-stacked transition-metal dichalcogenides (3R-TMDs), which are distinct from their hexagonal counterparts, exhibit higher carrier mobility, sliding ferroelectricity, and coherently enhanced nonlinear optical responses. However, surface epitaxial growth of large multilayer 3R-TMD single crystals is difficult. We report an interfacial epitaxy methodology for their growth of several compositions, including molybdenum disulfide (MoS2), molybdenum diselenide, tungsten disulfide, tungste...
• The AI Mirror:How to Reclaim Our Humanity in an Age of Machine Thinking AI翻译
  作者：Spezio, Michael
  作者单位：Claremont Colleges; Scripps College
• Lessons from failure AI翻译
  作者：Pramanik, Shreya
  作者单位：Oregon Health & Science University