作者：Li, Wei; Zhou, Tianzhu; Zhang, Zejun; Li, Lei; Lian, Wangwei; Wang, Yanlei; Lu, Junfeng; Yan, Jia; Wang, Huagao; Wei, Lei; Cheng, Qunfeng
作者单位：Beihang University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Nanyang Technological University; Renmin University of China; University of Shanghai for Science & Technology
摘要：Assembling titanium carbide (Ti3C2Tx) MXene nanosheets into macroscopic films presents challenges, including voids, low orientation degree, and weak interfacial interactions, which reduce mechanical performance. We demonstrate an ultrastrong macroscopic MXene film using liquid metal (LM) and bacterial cellulose (BC) to sequentially bridge MXene nanosheets (an LBM film), achieving a tensile strength of 908.4 megapascals. A layer-by-layer approach using repeated cycles of blade coating improves ...
作者：Mueller-Durovic, Bojana; Jager, Jessica; Engelmann, Christine; Schuhmachers, Patrick; Altermatt, Sabine; Schlup, Yannick; Duthaler, Urs; Makowiec, Celia; Unterstab, Gunhild; Roffeis, Sarah; Xhafa, Erta; Assmann, Nadine; Trulsson, Fredrik; Steiner, Rebekah; Edwards-Hicks, Joy; West, James; Turner, Lorinda; Develioglu, Leyla; Ivanek, Robert; Azzi, Tarik; Dehio, Philippe; Berger, Christoph; Kuzmin, Dmitry; Saboz, Sophie; Mautner, Josef; Loliger, Jordan; Geigges, Marco; Palianina, Darya; Khanna, Nina; Dirnhofer, Stefan; Munz, Christian; Bantug, Glenn R.; Hess, Christoph
作者单位：University of Basel; University of Basel; University of Zurich; University of Basel; University of Cambridge; University of Basel; University Children's Hospital Zurich; University Children's Hospital Zurich; Yale University; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; University of Basel; University of Basel; Novartis; Technical University of Munich
摘要：After infection of B cells, Epstein-Barr virus (EBV) engages host pathways that mediate cell proliferation and transformation, contributing to the propensity of the virus to drive immune dysregulation and lymphomagenesis. We found that the EBV protein EBNA2 initiates nicotinamide adenine dinucleotide (NAD) de novo biosynthesis by driving expression of the metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) in infected B cells. Virus-enforced NAD production sustained mitochondrial complex I a...
