A new path to migraine

• 成果类型: Editorial Material
• 署名作者: Russo, Andrew F.; Iliff, Jeffrey J.
• 署名单位: University of Iowa; US Department of Veterans Affairs; Veterans Health Administration (VHA); Iowa City VA Health Care System; US Department of Veterans Affairs; Veterans Health Administration (VHA); Vet Affairs Puget Sound Health Care System; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-9589
• DOI: 10.1126/science.adq3498
• 发表日期: 2024-07-05
• 页码: 28-29
• 关键词: cgrp

摘要

Migraine pain is believed to result from the activation of pain receptors (nociceptors) after the cortical spreading depression (CSD) that is associated with the aura phase of migraine ( 1 ). Previous studies have demonstrated that preclinical CSD events release small molecules through the cerebrospinal fluid (CSF) that activate and sensitize afferent trigeminal fibers within the meninges ( 2 , 3 ). However, it has been thought that trigeminal ganglia reside outside the blood-brain barrier and hence are not directly exposed to CSF ( 4 ). On page 80 of this issue, Rasmussen et al. ( 5 ) show in a mouse model of migraine that after CSD, subarachnoid CSF carries signals from the cortex directly to cell bodies in the trigeminal ganglia, where they activate nociceptors through a pathway that bypasses meningeal trigeminal afferents. The demonstration that the trigeminal ganglia lies within the blood-brain barrier and the identification of the signals that connect aura and headache may provide a new path for preventing and treating migraine.