Science

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• Retractions for Spanish rector AI翻译
  作者：Richter, Hannah
• Multi-omics landscape and molecular basis of radiation tolerance in a tardigrade AI翻译
  作者：Li, Lei; Ge, Zhengping; Liu, Shihao; Zheng, Kun; Li, Yaqi; Chen, Kaiqi; Fu, Yesheng; Lei, Xiaoguang; Cui, Zeling; Wang, Yifan; Huang, Jin; Liu, Yanyan; Duan, Mingwang; Sun, Zimei; Chen, Jun; Li, Liangwei; Shen, Pan; Wang, Guibin; Chen, Junmiao; Li, Ruochong; Li, Chaoran; Yang, Zhixiang; Ning, Yifan; Luo, Arong; Chen, Baoyu; Seim, Inge; Liu, Xin; Wang, Fei; Yao, Yishan; Guo, Fusheng; Yang, Maojun; Liu, Cui Hua; Fan, Guangyi; Wang, Lizhi; Yang, Dong; Zhang, Lingqiang
  作者单位：Qingdao University; Southern Theater Command General Hospital; Peking University; Shenzhen Bay Laboratory; University of South China; Anhui Medical University; Beijing Genomics Institute (BGI); Tsinghua University; Hebei University; Chinese Academy of Sciences; Institute of Zoology, CAS; Shaanxi Xueqian Normal University; Chinese Academy of Sciences; Institute of Deep-Sea Science & Engineering, CAS; Academy of Military Medical Sciences - China; Chinese Academy of Sciences; Institute of Microbiology, CAS
  摘要：Tardigrades are captivating organisms known for their resilience in extreme environments, including ultra-high-dose radiation, but the underlying mechanisms of this resilience remain largely unknown. Using genome, transcriptome, and proteome analysis of Hypsibius henanensis sp. nov., we explored the molecular basis contributing to radiotolerance in this organism. A putatively horizontally transferred gene, DOPA dioxygenase 1 (DODA1), responds to radiation and confers radiotolerance by synthesi...
• Wall of fame AI翻译
  作者：Getzler, Yutan
  作者单位：University System of Ohio; Kenyon College
• Reductive pathways in molten inorganic salts enable colloidal synthesis of III-V semiconductor nanocrystals AI翻译
  作者：Ondry, Justin C.; Zhou, Zirui; Lin, Kailai; Gupta, Aritrajit; Chang, Jun Hyuk; Wu, Haoqi; Jeong, Ahhyun; Hammel, Benjamin F.; Wang, Di; Fry, H. Christopher; Yazdi, Sadegh; Dukovic, Gordana; Schaller, Richard D.; Rabani, Eran; Talapin, Dmitri V.
  作者单位：University of Chicago; University of Chicago; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Colorado System; University of Colorado Boulder; United States Department of Energy (DOE); Argonne National Laboratory; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; Northwestern University; Tel Aviv University; University of Chicago
  摘要：Colloidal quantum dots, with their size-tunable optoelectronic properties and scalable synthesis, enable applications in which inexpensive high-performance semiconductors are needed. Synthesis science breakthroughs have been key to the realization of quantum dot technologies, but important group III-group V semiconductors, including colloidal gallium arsenide (GaAs), still cannot be synthesized with existing approaches. The high-temperature molten salt colloidal synthesis introduced in this wo...
• Open with care AI翻译
  作者：Ravindran, Sandeep
• A genetics gap in biodiversity AI翻译
  作者：Richter, Hannah
• Twenty years of microplastic pollution research-what have we learned? AI翻译
  作者：Thompson, Richard C.; Courtene-Jones, Winnie; Boucher, Julien; Pahl, Sabine; Raubenheimer, Karen; Koelmans, Albert A.
  作者单位：University of Plymouth; University of Vienna; University of Vienna; University of Wollongong; Wageningen University & Research
  摘要：Twenty years after the first publication that used the term microplastic, we review current understanding, refine definitions, and consider future prospects. Microplastics arise from multiple sources, including tires, textiles, cosmetics, paint, and the fragmentation of larger items. They are widely distributed throughout the natural environment, with evidence of harm at multiple levels of biological organization. They are pervasive in food and drink and have been detected throughout the human...
• Scalable protein design using optimization in a relaxed sequence space AI翻译
  作者：Frank, Christopher; Khoshouei, Ali; Fuss, Lara; Schiwietz, Dominik; Putz, Dominik; Weber, Lara; Zhao, Zhixuan; Hattori, Motoyuki; Feng, Shihao; de Stigter, Yosta; Ovchinnikov, Sergey; Dietz, Hendrik
  作者单位：Technical University of Munich; Technical University of Munich; Fudan University; Changping Laboratory; Harvard University; Massachusetts Institute of Technology (MIT)
  摘要：Machine learning (ML)-based design approaches have advanced the field of de novo protein design, with diffusion-based generative methods increasingly dominating protein design pipelines. Here, we report a hallucination-based protein design approach that functions in relaxed sequence space, enabling the efficient design of high-quality protein backbones over multiple scales and with broad scope of application without the need for any form of retraining. We experimentally produced and characteri...
• Distinct interfacial structures between grains AI翻译
  作者：Luo, Jian
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego
• Hematopoietic aging promotes cancer by fueling IL-1α-driven emergency myelopoiesis AI翻译
  作者：Park, Matthew D.; Le Berichel, Jessica; Hamon, Pauline; Wilk, C. Matthias; Belabed, Meriem; Yatim, Nader; Saffon, Alexis; Boumelha, Jesse; Falcomata, Chiara; Tepper, Alexander; Hegde, Samarth; Mattiuz, Raphael; Soong, Brian Y.; Lamarche, Nelson M.; Rentzeperis, Frederika; Troncoso, Leanna; Halasz, Laszlo; Hennequin, Clotilde; Chin, Theodore; Chen, Earnest P.; Reid, Amanda M.; Su, Matthew; Cahn, Ashley Reid; Koekkoek, Laura L.; Venturini, Nicholas; Wood-isenberg, Shira; D'souza, Darwin; Chen, Rachel; Dawson, Travis; Nie, Kai; Chen, Zhihong; Kim-Schulze, Seunghee; Casanova-Acebes, Maria; Swirski, Filip K.; Downward, Julian; Vabret, Nicolas; Brown, Brian D.; Marron, Thomas U.; Merad, Miriam
  作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Universite Paris Cite; Universite PSL; UNICANCER; Institut Curie; Institut National de la Sante et de la Recherche Medicale (Inserm); Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Francis Crick Institute; University of London; University College London; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Yale University; Yale University; Centro Nacional de Investigaciones Oncologicas (CNIO)
  摘要：Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In this study, we establish that aging of the immune system, regardless of the age of the stroma and tumor, drives lung cancer progression. Hematopoietic aging enhances emergency myelopoiesis, resulting in the local accumulation of myeloid progenitor-like cells in lung tumors. These cells are a major source of interleukin (IL)-1 alpha, which drives the enhanced myeloid response. The age-associated decli...