作者：Moffat, Jason; Komor, Alexis C.; Lum, Lawrence
作者单位：University of Toronto; Hospital for Sick Children (SickKids); University of California System; University of California San Diego; University of Texas System; University of Texas Southwestern Medical Center
作者：Cheng, Jiye; Venkatesh, Siddarth; Ke, Ke; Barratt, Michael J.; Gordon, Jeffrey I.
作者单位：Washington University (WUSTL); Washington University (WUSTL)
摘要：Undernutrition in Bangladeshi children is associated with disruption of postnatal gut microbiota assembly; compared with standard therapy, a microbiota-directed complementary food (MDCF) substantially improved their ponderal and linear growth. Here, we characterize a fatty acid amide hydrolase (FAAH) from a growth-associated intestinal strain of Faecalibacterium prausnitzii cultured from these children. This enzyme, expressed and purified from Escherichia coli, hydrolyzes a variety of N-acylam...
作者：Sansone, Nathalia Mariana Santos; Marques, Luiz Felipe Azevedo; Marson, Fernando Augusto Lima
作者：Greenbaum, Dov
作者单位：Reichman University; Reichman University; Yale University
作者：Sheahan, Madeline L.; Flores, Katia; Coyne, Michael J.; Garcia-Bayona, Leonor; Chatzidaki-Livanis, Maria; Holst, Andrea Q.; Smith, Rita C.; Sundararajan, Anitha; Barquera, Blanca; Comstock, Laurie E.
作者单位：University of Chicago; University of Chicago; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Technical University of Denmark; Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute; Stanford University; University System of Ohio; Ohio University; Chr Hansen
摘要：DNA transfer is ubiquitous in the human gut microbiota, especially among species of the order Bacteroidales. In silico analyses have revealed hundreds of mobile genetic elements shared between these species, yet little is known about the phenotypes they encode, their effects on fitness, or pleiotropic consequences for the recipient's genome. In this work, we show that acquisition of a ubiquitous integrative conjugative element (ICE) encoding a type VI secretion system (T6SS) shuts down the nat...
作者：Nosil, Patrik
作者单位：Centre National de la Recherche Scientifique (CNRS); Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Universite de Montpellier; Institut de Recherche pour le Developpement (IRD)
作者：Swamynathan, Manojit M.; Kuang, Shan; Watrud, Kaitlin E.; Doherty, Mary R.; Gineste, Charlotte; Mathew, Grinu; Gong, Grace Q.; Cox, Hilary; Cheng, Eileen; Reiss, David; Kendall, Jude; Ghosh, Diya; Reczek, Colleen R.; Zhao, Xiang; Herzka, Tali; Spokaite, Saule; Dessus, Antoine N.; Kim, Seung Tea; Klingbeil, Olaf; Liu, Juan; Nowak, Dawid G.; Alsudani, Habeeb; Wee, Tse-Luen; Park, Youngkyu; Minicozzi, Francesca; Rivera, Keith; Almeida, Ana S.; Chang, Kenneth; Chakrabarty, Ram P.; Wilkinson, John E.; Gimotty, Phyllis A.; Diermeier, Sarah D.; Egeblad, Mikala; Vakoc, Christopher R.; Locasale, Jason W.; Chandel, Navdeep S.; Janowitz, Tobias; Hicks, James B.; Wigler, Michael; Pappin, Darryl J.; Williams, Roger L.; Cifani, Paolo; Tuveson, David A.; Laporte, Jocelyn; Trotman, Lloyd C.
作者单位：Cold Spring Harbor Laboratory; State University of New York (SUNY) System; Stony Brook University; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); University of Nebraska System; University of Nebraska Medical Center; MRC Laboratory Molecular Biology; Northwestern University; Feinberg School of Medicine; North Carolina State University; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; NewYork-Presbyterian Hospital; University College Cork; University College Cork; University of Michigan System; University of Michigan; University of Pennsylvania; University of Otago; Johns Hopkins University; University of Southern California
摘要：Men taking antioxidant vitamin E supplements have increased prostate cancer (PC) risk. However, whether pro-oxidants protect from PC remained unclear. In this work, we show that a pro-oxidant vitamin K precursor [menadione sodium bisulfite (MSB)] suppresses PC progression in mice, killing cells through an oxidative cell death: MSB antagonizes the essential class III phosphatidylinositol (PI) 3-kinase VPS34-the regulator of endosome identity and sorting-through oxidation of key cysteines, point...
