Proceedings of the National Academy of Sciences of the United States of America

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• Protein dynamics underlies strong temperature dependence of heat receptors AI翻译
  作者：Mugo, Andrew Njagi; Chou, Ryan; Qin, Feng
  作者单位：State University of New York (SUNY) System; University at Buffalo, SUNY; Duke University; Duke University
  摘要：Ion channels are generally allosteric proteins, involving specialized stimulus sensor domains conformationally linked to the gate to drive channel opening. Temperature receptors are a group of ion channels from the transient receptor potential family. They exhibit an unprecedentedly strong temperature dependence and are responsible for temperature sensing in mammals. Despite intensive studies, however, the nature of the temperature sensor domain in these channels remains elusive. By direct cal...
• Structures of methane and ammonia monooxygenases in native membranes AI翻译
  作者：Tucci, Frank J.; Rosenzweig, Amy C.
  作者单位：Northwestern University; Northwestern University
  摘要：Methane- and ammonia- oxidizing bacteria play key roles in the global carbon and nitrogen cycles, respectively. These bacteria use homologous copper membrane monooxygenases to accomplish the defining chemical transformations of their metabolisms: the oxidations of methane to methanol by particulate methane monooxygenase (pMMO) and ammonia to hydroxylamine by ammonia monooxygenase (AMO), enzymes of prime interest for applications in mitigating climate change. However, investigations of these en...
• Evidence for a metal-bosonic insulator-superconductor transition in compressed sulfur AI翻译
  作者：Wang, Kui; Zhao, Hongjian; Liu, Guangtao; Zhou, Mi; Chen, Yinqi; Li, Qiushi; Ma, Guangchen; Wang, Hongbo; Hemley, Russell J.; Ma, Yanming
  作者单位：Jilin University; Jilin University; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; Jilin University
  摘要：The abrupt drop of resistance to zero at a critical temperature is a key signature of the current paradigm of the metal-superconductor transition. However, the emergence of an intermediate bosonic insulating state characterized by a resistance peak preceding the onset of the superconducting transition has challenged this traditional understanding. Notably, this phenomenon has been predominantly observed in disordered or chemically doped low- dimensional systems, raising intriguing questions ab...
• Restart uncertainty relation for monitored quantum dynamics AI翻译
  作者：Yin, Ruoyu; Wang, Qingyuan; Tornow, Sabine; Barkai, Eli
  作者单位：Bar Ilan University; Bundeswehr University Munich
  摘要：We introduce a time-energy uncertainty relation within the context of restarts in monitored quantum dynamics. Previous studies have established that the mean recurrence time, which represents the time taken to return to the initial state, is quantized as an integer multiple of the sampling time, displaying pointwise discontinuous transitions at resonances. Our findings demonstrate that the natural utilization of the restart mechanism in laboratory experiments, driven by finite data collection ...
• Muscle-specific increased expression of JAG1 improves the skeletal muscle phenotype in dystrophin-deficient mice AI翻译
  作者：de Souza Leite, Felipe; Lambert, Matthias R.; Zhang, Tracy Yuanfan; Conner, James R.; Paulo, Joao A.; Furtado Oliveira, Sheldon; Thakurta, Sanjukta Guha; Bowles, Jennifer; Gussoni, Emanuela; Gygi, Steven P.; Widrick, Jeffrey J.; Kunkel, Louis M.
  作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital
  摘要：Therapeutic strategies for Duchenne muscular dystrophy (DMD) will likely require complementary approaches. One possibility is to explore genetic modifiers that improve muscle regeneration and function. The beneficial effects of the overexpression of Jagged-1 were described in escaper golden retriever muscular dystrophy (GRMD) dogs that had a near-normal life and validated in dystrophin-deficient zebrafish. To clarify the underlying biology of JAG1 overexpression in dystrophic muscles, we gener...
• Severe water crisis in southern Spain under expanding irrigated agriculture: A multidimensional drought analysis AI翻译
  作者：Junquera, Victoria; Hormaza, Jose I.; Rubenstein, Daniel I.; Levin, Simon A.; Perez, Inaki Vadillo; Gavilan, Pablo Jimenez
  作者单位：University of Bern; Princeton University; Princeton University; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad de Malaga; CSIC-UMA - Instituto de Hortofruticultura Subtropical y Mediterranea La Mayora (IHSM); Universidad de Malaga
  摘要：The Axarqu & iacute;a region in southern Spain, a hotspot of avocado and mango production in Europe, underwent an extreme water crisis in 2019-2024. Reservoir levels dropped below the 8% outlet threshold and groundwater in the main aquifer dropped to sea level in several locations, risking seawater intrusion. Socioeconomic impacts ranged from substantial crop losses to a potential long-term decline in regional economic viability. We examine the main drivers of this crisis using a coupled human...
• Targeting endothelial ERG to mitigate vascular regression in retinopathies AI翻译
  作者：Ma, Eric; Schafer, Christopher M.; Xie, Jun; Rudenko, Yelyzaveta; Knapp, John T. H.; Randi, Anna M.; Birdsey, Graeme M.; Griffin, Courtney T.
  作者单位：Oklahoma Medical Research Foundation; Imperial College London; University of Oklahoma System; University of Oklahoma Health Sciences Center; University of Central Oklahoma
  摘要：Retinopathy of prematurity (ROP) and diabetic retinopathy (DR) are ocular disorders in which an initial loss of retinal capillaries leads to damaging tissue ischemia followed by a compensatory neovascularization response that generates pathological capillaries in the eye. Using a mouse model of ROP and samples from DR patients, we found that the highly homologous and homeostatic erythroblast transformation-specific (ETS) family transcription factors ETS-related gene (ERG) and Friend leukemia i...
• CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma AI翻译
  作者：Yang, Wu; Wang, Siying; Ji, Shuyi; Wang, Jian; Lian, Shuo; Li, Zhe; Jansen, Robin A.; Wu, Wei; Niu, Kongyan; Sun, Zhen; Jia, Qi; Zheng, Jiaojiao; Zhu, Huijue; Deng, Xuan; Wang, Liqin; Fan, Zhoulong; Shi, Yaoping; Lieftink, Cor; Guan, Ming; Beijersbergen, Roderick L.; Qin, Wenxin; Gao, Qiang; Bernards, Rene; Jin, Haojie
  作者单位：Shanghai Jiao Tong University; Netherlands Cancer Institute; Tongji University; Tongji University; Fudan University; Fudan University; Sun Yat Sen University; State Key Lab Oncology South China; Shanghai Jiao Tong University; Shanghai Jiao Tong University
  摘要：Cholangiocarcinoma (CCA) remains a lethal malignancy with limited therapeutic options. Through genome-wide CRISPR-Cas9 screening, we identified the adenosine triphosphatase (ATPase) valosin-containing protein (VCP) as a critical dependency in CCA. Compound screens revealed that the VCP inhibitor CB-5339 potently suppresses CCA proliferation in a panel of patient-derived organoids by inducing cellular senescence. It is known that senescent cells persist, and this can contribute to therapy resis...
• Earliest evidence of smoke-dried mummification: More than 10,000 years ago in southern China and Southeast Asia AI翻译
  作者：Hung, Hsiao-chun; Deng, Zhenhua; Liu, Yiheng; Ran, Zhiyu; Zhang, Yue; Li, Zhen; Kaifu, Yousuke; Huang, Qiang; Nguyen, Khanh Trung Kien; Le, Hai Dang; Xie, Guangmao; Nguyen, Anh Tuan; Yamagata, Mariko; Simanjuntak, Truman; Noerwidi, Sofwan; Fauzi, Mohammad Ruly; Tolla, Marlin; Wetipo, Alpius; He, Gang; Sawada, Junmei; Zhang, Chi; Bellwood, Peter; Matsumura, Hirofumi
  作者单位：Australian National University; Peking University; Peking University; University of Tokyo; Guangxi Normal University; Rikkyo University; National Research & Innovation Agency of Indonesia (BRIN); Niigata University of Health & Welfare; Australian National University; Sapporo Medical University
  摘要：In southern China and Southeast Asia (collectively, Southeastern Asia), Terminal Pleistocene and Early to Middle Holocene (ca. 12,000 to 4,000 cal. BP) hunter-gatherer burials feature tightly crouched or squatting postures, sometimes with indications of post-mortem dismemberment. Such burials contrast strongly with the extended supine burial postures typical of subsequent Neolithic inhumations in these regions. Their contorted postures, often with traces of burning, present interpretive challe...
• Kupffer cells are essential for platelet- mediated thrombopoietin generation in the liver AI翻译
  作者：Karakas, Danielle; Li, June; Ma, Wenjing; Wu, Xun Grace; Khoury, Christopher J.; Masoud, Mina; Hoard, Brock; Liu, Yuning Jay; Zhu, Guangheng; Chen, Junmei; Sim, Martha; Shen, Chuanbin; MacParland, Sonya A.; Lopez, Jose A.; Kahr, Walter H. A.; Ni, Heyu
  作者单位：University of Toronto; University of Toronto; Saint Michaels Hospital Toronto; University of Toronto; Canadian Blood Services; University of Washington; University of Washington Seattle; Ocean University of China; University of Toronto; University Health Network Toronto; University of Toronto; University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto
  摘要：Thrombopoietin (TPO), predominantly produced by the liver, is the key regulator for platelet production and the hematopoietic stem cell niche. Our earlier report demonstrated that platelet GPIb alpha is required for hepatocellular TPO generation, which is the major resource of TPO in the blood circulation. However, how hepatocytes physically contact circulating sinusoidal platelets across the liver endothelium for this process is unknown. Kupffer cells reside in contact with both sinusoidal bl...